Protective effect of a new nonpeptidyl mimetic of SOD, M40401, against focal cerebral ischemia in the rat

Brain Research

Volumn 963, Issue 1-2, 2003, Pages 8-14

  Shimizu, Katsuyoshi ^a,b   Rajapakse, Nishadi ^a   Horiguchi, Takashi ^a   Payne, R Mark ^a   Busija, David W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Federation of National Public Service Personnel Mutual Aid Associations   (Japan)

Author keywords

Cerebral ischemia; Middle cerebral artery occlusion; Superoxide anion

Indexed keywords

M 40401; MANGANESE SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFECT; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; BLOOD PRESSURE; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; FREE RADICAL SCAVENGERS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 0037435874     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03796-4     Document Type: Article

References (29)

1. Anderson M.F., Sims N.R. Mitochondrial respiratory function and cell death in focal cerebral ischemia. J. Neurochem. 73:1999;1189-1199.
2. Baker K., Marcus C.B., Huffman K., Kruk H., Malfroy B., Doctrow S.R. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284:1998;215-221.
3. Chan P.H. Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow. Metab. 21:2001;2-14.
4. Cuzzocrea S., Mazzon E., Dugo L., Caputi A.P., Aston K., Riley D.P., Salvemini D. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. Br. J. Pharmacol. 132:2001;19-29.
5. Masini E., Cuzzocrea S., Mazzon E., Marzocca C., Mannaioni P.F., Salvemini D. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br. J. Pharmacol. 136:2002;905-917.
6. Elsaesser R.S., Hungerhuber E., Zausinger S., Baethmann A., Reulen H.J. Combination drug therapy and mild hypothermia. A promising treatment strategy for reversible, focal cerebral ischemia. Stroke. 30:1999;1891-1899.
7. Francis J.W., Ren J.M., Warren L., Brown R.H. Jr., Finklestein S.P. Postischemic infusion of Cu/Zn Superoxide dismutase or SOD: Tet 451 reduces cerebral infarction following focal ischemia/reperfusion in rats. Exp. Neurol. 146:1997;435-443.
8. Fukuyama N., Takizawa S., Ishida H., Hoshiai K., Shinohara Y., Nakazawa H. Peroxynitrite formation in focal cerebral ischemia - reperfusion in rats occurs predominantly in the peri-infarct region. J. Cereb. Blood Flow Metab. 18:1998;123-129.
9. Fujimura M., Fujimura M.Y., Noshita N., Sugawara T., Kawase M., Chan P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 20:2000;2817-2824.
10. Garcia J.H., Wagner S., Liu K.F., Hu X.J. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 26:1995;627-635.
11. Gryglewski R.J., Palmer R.M.J., Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 320:1986;454-456.
12. Juurlink B.H. Response of glial cells to ischemia: Role of reactive oxygen species and glutathione. Neurosci. Biobehav. Rev. 21:1997;151-166.
13. Kawai H., Nakai H., Suga M., Yuki S., Watanabe T., Saito K. Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J. Pharmacol. Exp. Ther. 281:1997;921-927.
14. Keller J.N., Kindy M.S., Holtsberg F.W., St. Clair D.K., Yen H.C., Germeyer A., Steiner S.M., Keller A.J.B., Hutchins J.B. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18:1998;687-697.
15. Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., Chan P.H. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing Cu/Zn superoxide dismutase. Proc. Natl. Acad. Sci. USA. 88:1991;11158-11162.
16. Koizumi J., Yoshida Y., Nakazawa T., Ooneda G. Experimental studies of ischemic brain edema, 1: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke. 8:1986;1-8.
17. Kukreja R.C., Kontos H.A., Hess M.L., Ellis E.F. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ. Res. 59:1986;612-619.
18. Lin T.N., He Y.Y., Wu G., Khan M., Hsu C.Y. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 24:1993;117-121.
19. Liu X.H., Kato H., Araki T., Itoyama Y., Kato K., Kogure K. An immunohistochemical study of copper/zinc superoxide dismutase and manganese superoxide dismutase following focal cerebral ischemia in the rat. Brain Res. 644:1994;257-266.
20. Murakami K., Kondo T., Kawase M., Li Y., Sato S., Chen S.F., Chan P.H. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J. Neurosci. 18:1998;205-213.
21. Peters O., Back T., Lindauer U., Busch C., Megow D., Dreier J., Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 18:1998;196-205.
22. Salvemini D., Wang Z.Q., Zweier J.L., Samouilov A., Macarthur H., Misko T.P., Currie M.G., Cuzzocrea S., Sikorski J.A. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science. 286:1999;304-306.
23. Schmid-Elsaesser R., Hungerhuber E., Zausinger S., Baethmann A., Reulen H.J. Neuroprotective effects of the novel brain-penetrating antoxidant U-101033E and the spin-trapping agent α-phenyl-N-tert-butyl nitrone (PBN). Exp. Brain Res. 130:2000;60-66.
24. Siesjö B.K. Pathophysiology and treatment of focal cerebral ischemia: Part II: Mechanisms of damage and treatment. J. Neurosurg. 77:1992;337-354.
25. Swanson R.A., Morton M.T., Wu T.G., Savalos R.A., Davidson C., Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10:1990;290-293.
26. Traystman R.J., Kirsch J.R., Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71:1991;1185-1195.
27. Warner D.S., Martin H., Ludwig P., McAllister A., Keana J.F., Weber E. In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists. J. Cereb. Blood Flow Metab. 15:1995;188-196.
28. Yang Y., Li Q., Shuaib A. Neuroprotection by 2-h postischemia administration of two free radical scavengers, α-phenyul-n-tert-butyl-nitrone (PBN) and N-tert-butyl-(2-sulfophenyl)-nitrone (S-PBN), in rats subjected to focal embolic cerebral ischemia. Exp. Neurol. 163:2000;39-45.
29. Ying W., Anderson C.M., Chen Y., Stein B.A., Fahlman C.S., Copin J.C., Chan P.H., Swanson R.A. Differing effects of copper zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins. J. Cereb. Blood Flow Metab. 20:2000;359-368.