Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 2, 2000, Pages 359-368

  Ying, Weihai ^a   Anderson, Christopher M ^a   Chen, Yongmei ^a   Stein, Becky A ^a   Fahlman, Christian S ^a   Copin, Jean Christophe ^b   Chan, Pak H ^b   Swanson, Raymond A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Cell culture; Glutamate; Ischemia; Neuronal death; Superoxide dismutase; Transgenic

Indexed keywords

3 NITROTYROSINE; COPPER ZINC SUPEROXIDE DISMUTASE; DIETHYLAMINE; EXCITOTOXIN; GLUTAMIC ACID; KAINIC ACID; MENADIONE; N ACETYL S NITROSOPENICILLAMINE; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE; NITRIC OXIDE DONOR; PEROXIDE; REACTIVE OXYGEN METABOLITE; SPERMINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

EID: 0033955710     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200002000-00018     Document Type: Article

References (21)

1. Amstad P, Moret R, Cerutti P (1994) Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn Superoxide dismutase overproducers to oxidant stress. J Biol Chem 269:1606-1609
2. Aspberg A, Tottmar O (1992) Development of antioxidant enzymes in rat brain in reasgregation culture of fetal brain cells. Dev Brain Res 66:55-58
3. Bailey HH (1998) L-S,R-buthionine sulfoximine: historical development and clinical issues. Cheimco-Biol Interaction 111, 112:239-254
4. Banbury Conference on Genetic Background in Mice (1997) Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19:755-759
5. Bar-Peled O, Korkotian E, Segal M, Groner Y (1996) Constitutive overexpression of Cu/Zn Superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn Superoxide dismutase neurons. Proc Natl Acad Sci USA 93:8530-8535
6. Beckman JS, Ischiropoulos H, Zhu L, van der Woerd M, Smith C, Chen J, Harrison J, Martin JC, Tsai M (1992) Kinetics of Superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys 298:438-445
7. Beckman JS, Koppenol WH (1996) Nitric oxide, Superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 271:C1424-C1437
8. Cabelli DE, Allen D, Bielski BH, Holcman J (1989) The interaction between Cu(I) Superoxide dismutase and hydrogen peroxide. J Biol Chem 264:9967-9971
9. Cadenas E, Sies H (1985) Oxidative stress: excited oxygen species and enzyme activity. Adv Enzyme Regul 23:217-237
10. Chan PH, Chu L, Chen SF, Carlson EJ, Epstein CJ (1990) Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase. Stroke 21(suppl 11):III80-82
11. Chan PH, Kamii H, Yang G, Gafni J, Epstein CJ, Carlson E, Reola L (1993) Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. Neuroreport 5:293-296
12. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129
13. Chan PH, Kawase M, Murakami K, Chen SF, Li Y, Calagui B, Reola L, Carlson E, Epstein C (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18: 8292-8299
14. Crapo JD, McCord JM, Fridovich I (1978) Preparation and assay of Superoxide dismutases. Methods Enzymol 53:382-393
15. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate toxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371
16. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661
17. de Haan JB, Cristiano F, Iannello R, Bladier C, Kelner MJ, Kola I (1996) Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet 5:283-292
18. Vanden Hoek TL, Shao Z, Li C, Schumacker PT, Becker LB (1997) Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. J Mol Cell Cardiol 29: 2441-2450
19. Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Kamii H (1994) Human copper-zinc Superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25:165-170
20. Yim MB, Yim H-S, Chock PB, Stadtman ER (1990) Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide. Proc Natl Acad Sci USA 87:5006-5010
21. Ying W, Han S-K, Miller JW, Swanson RA (1999) Acidosis potentiates oxidative neuronal death by multiple mechanisms. J Neurochem 73:1549-1556