On the interaction between gp41 and membranes: The immunodominant loop stabilizes gp41 helical hairpin conformation

Journal of Molecular Biology

Volumn 326, Issue 5, 2003, Pages 1489-1501

  Peisajovich, Sergio G ^a   Blank, Lior ^a   Epand, Raquel F ^b   Epand, Richard M ^b   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Conformational change; HIV cell entry; Membrane fusion

Indexed keywords

GLYCOPROTEIN GP 41; RHODAMINE; TRYPTOPHAN; VIRUS PROTEIN;

AQUEOUS SOLUTION; ARTICLE; CALORIMETRY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIMIAN IMMUNODEFICIENCY VIRUS; SPECTROSCOPY; SURFACE PLASMON RESONANCE;

HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0037424624     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00040-8     Document Type: Article

References (40)

1. Dalgleish A.G., Beverley P.C., Clapham P.R., Crawford D.H., Greaves M.F., Weiss R.A. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature. 312:1984;763-767.
2. Alkhatib G., Combadiere C., Broder C.C., Feng Y., Kennedy P.E., Murphy P.M., Berger E.A. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 272:1996;1955-1958.
3. Feng Y., Broder C.C., Kennedy P.E., Berger E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 272:1996;872-877.
4. Bosch M.L., Earl P.L., Fargnoli K., Picciafuoco S., Giombini F., Wong-Staal F., Franchini G. Identification of the fusion peptide of primate immunodeficiency viruses. Science. 244:1989;694-697.
5. Gallaher W.R. Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus. Cell. 50:1987;327-328.
6. Harter C., James P., Bachi T., Semenza G., Brunner J. Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide" J. Biol. Chem. 264:1989;6459-6464.
7. Gallaher W.R., Ball J.M., Garry R.F., Griffin M.C., Montelaro R.C. A general model for the transmembrane proteins of HIV and other retroviruses. AIDS Res. Hum. Retroviruses. 5:1989;431-440.
8. Blacklow S.C., Lu M., Kim P.S. A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry. 34:1995;14955-14962.
9. Lu M., Blacklow S.C., Kim P.S. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nature Struct. Biol. 2:1995;1075-1082.
10. Chan D.C., Fass D., Berger J.M., Kim P.S. Core structure of gp41 from the HIV envelope glycoprotein. Cell. 89:1997;263-273.
11. Weissenhorn W., Dessen A., Harrison S.C., Skehel J.J., Wiley D.C. Atomic structure of the ectodomain from HIV-1 gp41. Nature. 387:1997;426-430.
12. Caffrey M., Cai M., Kaufman J., Stahl S.J., Wingfield P.T., Covell D.G., et al. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17:1998;4572-4584.
13. Wild C.T., Shugars D.C., Greenwell T.K., McDanal C.B., Matthews T.J. Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection. Proc. Natl Acad. Sci. USA. 91:1994;9770-9774.
14. Bullough P.A., Hughson F.M., Skehel J.J., Wiley D.C. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature. 371:1994;37-43.
15. Skehel J.J., Wiley D.C. Coiled coils in both intracellular vesicle and viral membrane fusion. Cell. 95:1998;871-874.
16. Furuta R.A., Wild C.T., Weng Y., Weiss C.D. Capture of an early fusion-active conformation of HIV-1 gp41. Nature Struct. Biol. 5:1998;276-279.
17. Kliger Y., Peisajovich S.G., Blumenthal R., Shai Y. Membrane-induced conformational change during the activation of HIV-1 gp41. J. Mol. Biol. 301:2000;905-914.
18. Peisajovich S.G., Shai Y. SIV gp41 binds to membranes both in the monomeric and trimeric states: consequences for the neuropathology and inhibition of HIV infection. J. Mol. Biol. 311:2001;249-254.
19. Ben-Efraim I., Kliger Y., Hermesh C., Shai Y. Membrane-induced step in the activation of Sendai virus fusion protein. J. Mol. Biol. 285:1999;609-625.
20. Epand R.F., Macosko J.C., Russell C.J., Shin Y.K., Epand R.M. The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. J. Mol. Biol. 286:1999;489-503.
21. Ghosh J.K., Shai Y. Direct evidence that the N-terminal heptad repeat of Sendai virus fusion protein participates in membrane fusion. J. Mol. Biol. 292:1999;531-546.
22. Peisajovich S.G., Samuel O., Shai Y. The F1 protein of paramyxoviruses has two fusion peptides: implications for the mechanism of membrane fusion. J. Mol. Biol. 296:2000;1353-1365.
23. Suarez T., Gallaher W.R., Agirre A., Goni F.M., Nieva J.L. Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion. J. Virol. 74:2000;8038-8047.
24. Caffrey M., Kaufman J., Stahl S., Wingfield P., Gronenborn A.M., Clore G.M. Monomer-trimer equilibrium of the ectodomain of SIV gp41: insight into the mechanism of peptide inhibition of HIV infection. Protein Sci. 8:1999;1904-1907.
25. Kliger Y., Gallo S.A., Peisajovich S.G., Munoz-Barroso I., Avkin S., Blumenthal R., Shai Y. Mode of action of an antiviral peptide from HIV-1. Inhibition at a post-lipid mixing stage. J. Biol. Chem. 276:2001;1391-1397.
26. Caffrey M., Cai M., Kaufman J., Stahl S.J., Wingfield P.T., Gronenborn A.M., Clore G.M. Determination of the secondary structure and global topology of the 44 kDa ectodomain of gp41 of the simian immunodeficiency virus by multidimensional nuclear magnetic resonance spectroscopy. J. Mol. Biol. 271:1997;819-826.
27. Jackson M., Mantsch H.H. The use and misuse of FTIR spectroscopy in the determination of protein structure. Crit. Rev. Biochem. Mol. Biol. 30:1995;95-120.
28. Epand R.F., Epand R.M., Jung C.Y. Ligand-modulation of the stability of the glucose transporter GLUT 1. Protein Sci. 10:2001;1363-1369.
29. Del Real G., Jimenez-Baranda S., Lacalle R.A., Mira E., Lucas P., Gomez-Mouton C., et al. Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains. J. Exptl Med. 196:2002;293-301.
30. Percherancier Y., Lagane B., Planchenault T., Staropoli I., Altmeyer R., Virelizier J.L., et al. HIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, raft membrane domains. J. Biol. Chem. 12:2002;00. epub ahead of printing on Nov. 12 as Manuscript M207371200.
31. Kozak S.L., Heard J.M., Kabat D. Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus. J. Virol. 76:2002;1802-1815.
32. Caffrey M. Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop. Biochim. Biophys. Acta. 1536:2001;116-122.
33. Wingfield P.T., Stahl S.J., Kaufman J., Zlotnick A., Hyde C.C., Gronenborn A.M., Clore G.M. The extracellular domain of immunodeficiency virus gp41 protein: expression in Escherichia coli, purification, and crystallization. Protein Sci. 6:1997;1653-1660.
34. Ji H., Bracken C., Lu M. Buried polar interactions and conformational stability in the simian immunodeficiency virus (SIV) gp41 core. Biochemistry. 39:2000;676-685.
35. Liu J., Shu W., Fagan M.B., Nunberg J.H., Lu M. Structural and functional analysis of the HIV gp41 core containing an Ile573 to Thr substitution: implications for membrane fusion. Biochemistry. 40:2001;2797-2807.
36. Shu W., Ji H., Lu M. Interactions between HIV-1 gp41 core and detergents and their implications for membrane fusion. J. Biol. Chem. 275:2000;1839-1845.
37. Finnegan C.M., Berg W., Lewis G.K., DeVico A.L. Antigenic properties of the human immunodeficiency virus transmembrane glycoprotein during cell-cell fusion. J. Virol. 76:2002;12123-12134.
38. Caffrey M., Braddock D.T., Louis J.M., Abu-Asab M.A., Kingma D., Liotta L., et al. Biophysical characterization of gp41 aggregates suggests a model for the molecular mechanism of HIV-associated neurological damage and dementia. J. Biol. Chem. 275:2000;19877-19882.
39. Gazit E., Miller I.R., Biggin P.C., Sansom M.S., Shai Y. Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. J. Mol. Biol. 258:1996;860-870.
40. Surewicz W.K., Mantsch H.H., Chapman D. Determination of protein secondary structure by Fourier transform infrared spectroscopy: a critical assessment. Biochemistry. 32:1993;389-394.