Model for the structure of the HIV gp41 ectodomain: Insight into the intermolecular interactions of the gp41 loop

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1536, Issue 2-3, 2001, Pages 116-122

  Caffrey, Michael ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

AIDS; Complement; Envelope proteins; gp120

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C1Q; ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; VIRUS PROTEIN;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMIAN IMMUNODEFICIENCY VIRUS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; COMPLEMENT C1Q; COMPUTER SIMULATION; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RETROVIRIDAE PROTEINS; SEQUENCE ALIGNMENT;

HUMAN IMMUNODEFICIENCY VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0035978480     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(01)00042-4     Document Type: Article

References (29)

1. HIV-1: Fifteen proteins and an RNA
2. Structural biology of HIV
3. HIV-1 protease inhibitors: A review
4. Current approaches to treatment for HIV-1 infection
5. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing antibody
6. The antigenic structure of the HIV gp120 envelope glycoprotein
7. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
8. Changes in the transmembrane region of the human immunodeficiency virus type-1 gp41 envelope glycoprotein affect membrane fusion
9. The NH2-terminal 31 amino acids of human immunodeficiency virus type-1 envelope protein gp120 contain a potential gp41 contact site
10. Core structure of gp41 from the HIV envelope glycoprotein
11. Atomic structure of the ectodomain from HIV-1 gp41
12. Atomic structure of a thermostable subdomain of HIV-1 gp41
13. Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides
14. The crystal structure of the SIV gp41 ectodomain at 1.47 angstrom resolution
15. Determination of the secondary structure and global topology of the 44 kDa ectodomain of gp41 of the simian immunodeficiency virus by multidimensional nuclear magnetic resonance spectroscopy
16. Solution structure of the 44 kDa ectodomain of SIV gp41
17. 15N relaxation data of large proteins: Application to the 44 kDa ectodomain of SIV gp41
18. Monomer-trimer equilibrium of the ectodomain of SIV gp41: Insight into the mechanism of peptide inhibition of HIV infection
19. Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein
20. A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure
21. Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1
22. Mapping of the interaction between the immunodominant loop of the ectodomain of HIV-1 gp41 and human complement protein C1q
23. B cells of HIV-1 infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells
24. Crystallography and NMR system: A new software suite for macromolecular structure determination
25. MOLMOL: A program for display and analysis of macromolecular structures
26. HIV/SIV glycoproteins: Structure-function relationships
27. A role for surface hydrophobicity in protein-protein recognition
28. Principles of protein-protein interactions
29. Complement activation by HIV-1 infected cells: The role of transmembrane glycoprotein gp41