Impaired production of cytokines is an independent predictor of mortality in HIV-1-infected patients

AIDS

Volumn 17, Issue 4, 2003, Pages 521-530

  Ostrowski, Sisse R ^a   Gerstoft, Jan ^a   Pedersen, Bente K ^a   Ullum, Henrik ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Cellular factors cytokines; Cellular immunity; HIV 1; Natural history; Pathogenesis; Prognosis

Indexed keywords

CYTOKINE; INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN RECEPTOR; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; RECEPTOR ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD CELL; BLOOD CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RISK;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CYTOKINES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; PROGNOSIS; REGRESSION ANALYSIS; SURVIVAL ANALYSIS; VIRAL LOAD;

EID: 0037423818     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200303070-00007     Document Type: Article

References (40)

1. Oppenheim JJ. Cytokines: past, present, and future. Int J Hematol 2001, 74:3-8.
2. Spellberg B, Edwards JE Jr. Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis 2001, 32:76-102.
3. Poli G, Fauci AS. Cytokine modulation of HIV expression. Semin Immunol 1993, 5:165-173.
4. Fauci AS. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993, 262: 1011-1018.
5. Pantaleo G, Fauci AS. Immunopathogenesis of HIV infection. Annu Rev Microbiol 1996, 50:825-854.
6. Graziosi C, Pantaleo G, Gantt KR, Fortin JP, Demarest JF, Cohen OJ, et al. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science 1994, 265:248-252.
7. Alonso K, Pontiggia P, Medenica R, Rizzo S. Cytokine patterns in adults with AIDS. Immunol Invest 1997, 26:341-350.
8. Fakoya A, Matear PM, Filley E, Rook GA, Stanford J, Gilson RJ, et al. HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state. AIDS 1997, 11:1445-1452.
9. Clerici M, Shearer GM. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993, 14: 107-111.
10. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunol Today 1994, 15:575-581.
11. Barcellini W, Rizzardi GP, Borghi MO, Fain C, Lazzarin A, Meroni PL. TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994, 8:757-762.
12. Meyaard L, Hovenkamp E, Keet IP, Hooibrink B, de Jong JI, Otto SA, et al. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production. J Immunol 1996, 157:2712-2718.
13. Ullum H, Lepri AC, Bendtsen K, Victor J, Gøtzsche PC, Phillips AN, et al. Low production of IFNg is related to disease progression in HIV infection: evidence from a cohort of 347 HIV-infected individuals. AIDS Res Hum Retrovir 1997, 13:1039-1046.
14. Dinarello CA. Proinflammatory cytokines. Chest 2000, 118: 503-508.
15. Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest 2000, 117:1162-1172.
16. Poli G, Kinter A, Justement JS, Kehrl JH, Bressler P, Stanley S, et al. Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression. Proc Natl Acad Sci USA 1990, 87:782-785.
17. Hiscott J, Kwon H, Genin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest 2001, 107: 143-151.
18. Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Front Biosci 1997, 2:d12-d26.
19. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136:2348-2357.
20. Street NE, Mosmann TR. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J 1991, 5:171-177.
21. Romagnani S. Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease. Int J Clin Lab Res 1991, 21:152-158.
22. Firestein GS, Roeder WD, Laxer JA, Townsend KS, Weaver CT, Hom JT, et al. A new murine CD4+ T cell subset with an unrestricted cytokine profile. J Immunol 1989, 143:518-525.
23. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996, 17:138-146.
24. Centers for Disease Control. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Mort Morb Wkly Rep 1992, 41:1-19.
25. Ullum H, Gøtzsche PC, Victor J, Dickmeiss E, Skinhoj P, Pedersen BK. Defective natural immunity:an early manifestation of Human Immune Defiency Virus Infection. J Exp Med 1995, 182:789-799.
26. De Groote D, Zangerle PF, Gevaert Y, Fassotte MF, Beguin Y, Noizat-Pirenne F, et al. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. Cytokine 1992, 4:239-248.
27. Desch CE, Kovach NL, Present W, Broyles C, Harlan JM. Production of human tumor necrosis factor from whole blood ex vivo. Lymphokine Res 1989, 8:141-146.
28. Kwak DJ, Augustine NH, Borges WG, Joyner JL, Green WF, Hill HR. Intracellular and extracellular cytokine production by human mixed mononuclear cells in response to group B streptococci. Infect Immun 2000, 68:320-327.
29. Clerici M, Stocks NI, Zajac RA, Boswell RN, Lucey DR, Via CS, et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989, 84:1892-1899.
30. Klein SA, Dobmeyer JM, Dobmeyer TS, Pape M, Ottmann OG, Helm EB, et al. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS 1997, 11:1111-1118.
31. Grossman Z, Meier-Schellersheim M, Sousa AE, Victorino RM, Paul WE. CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause? Nat Med 2002, 8:319-323.
32. Miedema F. Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance. Immunodefic Rev 1992, 3:173-193.
33. Janossy G, Borthwick N, Lomnitzer R, Medina E, Squire SB, Phillips AN, et al. Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45R0+ cells of the CD4 and CD8 lineages. AIDS 1993, 7:613-624.
34. Clerici M, Balotta C, Meroni L, Ferrario E, Riva C, Trabattoni D, et al. Type 1 cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection. AIDS Res Hum Retrovir 1996, 20:1053-1061.
35. Weissman D, Poli G, Fauci AS. Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus. AIDS Res Hum Retrovir 1994, 10:1199-1206.
36. Fernandez-Botran R. Soluble cytokine receptors: basic immunology and clinical applications. Crit Rev Clin Lab Sci 1999, 36:165-224.
37. Jacobs CA, Beckmann MP, Mohler K, Maliszewski CR, Fanslow WC, Lynch DH. Pharmacokinetic parameters and biodistribution of soluble cytokine receptors. Int Rev Exp Pathol 1993, 34 Pt B:123-135.
38. Heaney ML, Golde DW. Soluble receptors in human disease. J Leukoc Biol 1998, 64:135-146.
39. Cozzi LA, Katzenstein TL, Ullum H, Phillips AN, Skinhoj P, Gerstoft J, et al. The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection. AIDS 1998, 12:1639-1643.
40. Fahey JL, Taylor JM, Manna B, Nishanian P, Aziz N, Giorgi JV, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 1998, 12:1581-1590.