Mechanism of hepatoprotective action of bile salts in liver disease

Gastroenterology Clinics of North America

Volumn 28, Issue 1, 1999, Pages 195-209

  Stiehl, A ^a   Benz, C ^a   Sauer, P ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; LIVER ENZYME; URSODEOXYCHOLIC ACID;

ALCOHOL LIVER DISEASE; BIOCHEMISTRY; CHOLESTASIS; CHOLESTATIC HEPATITIS; CHRONIC HEPATITIS; HEPATITIS C; HUMAN; LIVER DISEASE; LIVER HISTOLOGY; LIVER PROTECTION; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; REVIEW;

EID: 0032915395     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8553(05)70050-9     Document Type: Article

References (108)

1. D.H. Adams S.G. Hubscher J. Shaw Increased expression of intercellular adhesion molecule 1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis Hepatology 14 1991 426
2. C.O. Albertani H.J. Zimmerman K.G. Ishak Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate: An ultrastructural study Proc Soc Exp Biol Med 199 1992 54
3. W.F. Balisteri Bile acid therapy in pediatric hepatobiliary disease: The role of ursodeoxycholic acid J Pediatr Gastroenterol Nutr 24 1997 573
4. D. Barnes D. Talenti G. Cammell A randomized clinical trial of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection Hepatology 26 1997 853
5. S.G. Barnwell P.J. Lowe R. Coleman Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-menbrane enzymes, and the extent of cell damage, in isolated perfused rat livers Biochem J 216 1983 107
6. A.K. Batta G. Salen R. Arora Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis Hepatology 10 1989 414
7. P. Beau J. Labat-Labourdette P. Ingrand M. Beauchant Is ursodeoxycholic acid an effective therapy for total parenteral nutrition-related liver disease? J Hepatol 20 1994 240
8. C. Benz S. Angermüller U. Töx Effect of tauroursodeoxycholic acid on bile acid induced apoptosis and cytolysis in rat hepatocytes J Hepatol 28 1998 99
9. C. Benz P. Sauer P. Klöters-Plachky Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid induced apoptosis and cytolysis in rat hepatocytes Eur J Clin Invest 28 1998 577
10. P.A. Berg R. Klein M. Röcken Cytokines in primary biliary cirrhosis Semin Liver Dis 17 1997 115
11. ++ mechanisms defective in cholestasis J Clin Invest 92 1993 2984
12. U. Beuers U. Spengler W. Kruis Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo controlled trial Hepatology 16 1992 707
13. U. Beuers D.C. Throckmorton M.S. Anderson Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes Gastroenterology 110 1996 1553
14. P.O. Bittner H.G. Posselt T. Sailer The effect of treatment with ursodeoxycholic acid in cystic fibrosis and hepatopathy: Results of a placebo-controlled study Paumgartner G. Stiehl A. Gerok W. Bile Acids as Therapeutic Agents 1991 Kluwer Dordrecht, The Netherlands 345
15. R. Botla J.R. Spivey H. Aguilar Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane transition induced by chenodeoxycholate: A mechnism of UDCA protection J Pharmacol Exp Ther 272 1995 930
16. G. Buzzelli S. Moscarella G. Focardi Long-term treatment with ursodeoxycholic acid in patients with chronic active cirrhosis Curr Ther Res 50 1991 635
17. Y. Calmus C. Arvieux P. Gone Cholestasis induces major histocompatibility class I expression in hepatocytes Gastroenterology 102 1992 1371
18. Y. Calmus P. Gane P. Rouger Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid Hepatology 11 1990 12
19. Y. Calmus J. Guechot P. Podevin Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes Hepatology 16 1992 719
20. Y. Calmus B. Weill Y. Ozier Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse Gastroenterology 103 1992 617
21. C. Colombo M.R. Castellani W.F. Balisteri Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease Hepatology 15 1992 677
22. C. Colombo A. Crossignani M. Assaido Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: A dose-response study Hepatology 16 1992 924
23. C. Colombo K.D.R. Setchell Podda M. Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis J Pediatr 117 1990 482
24. B. Combes R.L. Carithers W.C. Maddrey A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 22 1995 759
25. J. Cotting M.J. Lentze J. Reichen Effects of ursodeoxycholic acid therapy on nutrition and liver function in patients with cystic fibrosis and long-standing cholestasis Gut 31 1990 918
26. A. Crosignani P.M. Battezzati M. Bertolini Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration Hepatology 14 1991 1000
27. Duerksen D.R. Van Aerde J.E. L. Gramlich Intravenous ursodeoxycholic acid reduces cholestasis in parenterally fed newborn piglets Gastroenterology 111 1996 1111
28. S. Eusufzai S. Ericson T. Cederlund Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SEHCAT test Gut 32 1991 1044
29. T. Fedorowski G. Salen A. Colallilo Metabolism of ursodeoxycholic acid in man Gastroenterology 73 1977 1131
30. T. Fedorowski G. Salen G.S. Tint Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria Gastroenterology 77 1979 1068
31. A. Floreani M. Chiaramonte P. Fabris Poor effect of ursodeoxycholic acid in anti-hepatitis C virus positive chronic liver disease Curr Ther Res 50 1991 579
32. E.E. Frezza G.E. Gerunda M. Plebani Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rat Dig Dis Sci 38 1993 1291
33. H. Fromm G.L. Carlson A.F. Hofmann Metabolism in man of 7-ketolithocholic acid: Precursor of cheno- and ursodeoxycholic acid Am J Physiol 239 1980 G161
34. P.R. Galle L. Theilmann R. Raedsch Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes Hepatology 12 1990 486
35. H. Greim D. Trülzsch P. Czygan Mechanisms of cholestasis: 6. Bile acids in human livers with and without biliary obstruction Gastroenterology 63 1972 846
36. H. Greim D. Trülzsch J. Roboz Mechanisms of cholestasis: 5. Bile acids in normal rat livers and those after bile duct ligation Gastroenterology 63 1972 837
37. S. Güldütuna G. Zimmer M. Imhof Molecular aspects of membrane stabilization by ursodeoxycholate Gastroenterology 104 1993 1736
38. E.J.L. Heathcote K. Cauch-Dudek V. Walker The Canadian multi-center double blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 19 1994 1149
39. M. Hertl P.R. Harvey P.E. Swanson Evidence of preservation injury to bile ducts by bile salts in the pig and its prevention by infusions of hydrophilic bile salts Hepatology 21 1995 1130
40. D.M. Heuman R. Bajaj Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts Gastroenterology 106 1994 1333
41. D.M. Heuman R.S. Bajaj Q. Lin Adsorption mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: Implications for bile salt toxicity and protection J Lipid Res 37 1996 562
42. D.M. Heuman A.S. Mills J.B. McCall Conjugates of ursodeoxycholate protect against cholestasis and hepatocelllular necrosis caused by more hydrophobic bile salts: In vivo studies in the rat Gastroenterology 100 1991 203
43. D.M. Heuman W.M. Pandak P.B. Hylemon Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes Hepatology 14 1991 920
44. S. Hillaire E. Boucher Y. Calmus Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes Gastroenterology 107 1994 781
45. F. Hirano H. Tanaka Y. Makino Regulation of the major histocompatibility complex class I mRNA expression by bile salts in cultured human hepatoma cells Biochim Biophys Res Commun 208 1995 935
46. F. Hirano H. Tanaka Y. Makino Effects of ursodeoxycholc acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression J Gastroenterol 31 1996 55
47. A.F. Hofmann Pharmacology of chenodeoxycholic acid and ursodeoxycholic acid in man Paumgartner G. Stiehl A. Gerok W. Bile Acids and Cholesterol in Health and Disease 1983 Kluwer Dordrecht, The Netherlands 301
48. A.F. Hofmann Bile acid hepatotoxicity and the rationale of UDCA therapy in chronic cholestatic liver disease: Some hypotheses Paumgartner G. Stiehl A. Barbara L. Strategies for the Treatment of Hepatobiliary Diseases 1990 Kluwer Dordrecht, The Netherlands 13
49. A.F. Hofmann H. Popper Ursodeoxycholic acid treatment for primary biliary cirrhosis Lancet 2 1987 398
50. H. Igimi M.C. Carey pH solubility relations of chenodeoxycholic and ursodeoxycholic acids: Physical chemical basis for dissimilar solution and membrane phenomena J Lipid Res 21 1980 72
51. P. Invernizzi K.D.R. Setchell A. Crossignani Comparison between tauroursodeoxycholic and ursodeoxycholic acids in patients with primary biliary cirrhosis: A crossover study [abstr] J Hepatology 26 suppl 1 1997 166
52. S. Kanai K. Kitani Glycoursodeoxycholate is as effective as tauroursodeoxycholate in preventing the taurocholate-induced cholestasis in the rat Res Commun Chem Pathol Pharmacol 42 1983 423
53. S. Kinbara K. Ishizaki H. Sakakura Improvement of estradiol-17beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats Scand J Gastroenterol 32 1997 947
54. K. Kitani S. Kanai Y. Sato Tauro-alpha-muricholate is as effective as tauro-beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat Hepatology 19 1994 1007
55. K. Kitani M. Ohta S. Kanai Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat Am J Physiol 248 1985 G407
56. R. Klein M. Leuschner U. Leuschner Cytokine profiles in primary biliary cirrhosis and primary sclerosing cholangitis Berg P.A. Leuschner U. Bile Acids and Immunology 1996 Kluwer Dordrecht, The Netherlands 195
57. S. Krähenbühl S. Fischer C. Talos Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria Hepatology 20 1994 1595
58. P. Kwo S.F. Bronk G.J. Gores Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes Am J Physiol 268 1995 G613
59. F. Lacaille K. Paradis The immunosuppressive effect of ursodeoxycholic acid: A comparative in vitro study of human peripheral blood mononuclear cells Hepatology 18 1993 165
60. G. Lepage K. Paradis F. Lacaille Ursodeoxycholic acid improves the hepatic metabolism of essential fatty acids and retinol in children with cystic fibrosis J Pediatr 130 1997 52
61. U. Leuschner H. Fischer W. Kurtz Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial Gastroenterology 97 1989 1268
62. U. Leuschner M. Leuschner J. Sieratzki Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years' follow-up Dig Dis Sci 30 1985 642
63. A.G. Lim H.A. Ahmed R.P. Jazrawi Effects of bile acids on human hepatic mitochondria Eur J Hepatol Gastroenterol 6 1994 1157
64. K.D.L. Lindor E.R. Dickson W.P. Baldus Ursodeoxycholic acid in the treatment of primary biliary cirrhosis Gastroenterology 106 1994 1284
65. Lindor K.D. Mayo PSC/UDCA study group. Ursodiol for the treatment of primary sclerosing cholangitis N Engl J Med 336 1997 691
66. P. Ljubuncic B. Fuhrman J. Oiknine Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages Gut 39 1996 475
67. P. Loria M. Bozzoli M. Concari Effect of taurohyodeoxcholic acid on biliary lipid secretion in humans Hepatology 25 1997 1306
68. E. Lotterer A. Stiehl R. Raedsch Ursodeoxycholic acid in primary biliary cirrhosis: No evidence of toxicity in the stages I to III J Hepatol 10 1990 284
69. P. Marteau O. Chazouilleres A. Myara Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man Hepatology 12 1990 1206
70. G. Mazzella P. Parini F. Bazzoli Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis Dig Dis Sci 38 1993 896
71. S.A. Mitchell D. Bansi N. Hunt High dose ursodeoxycholic acid (UDCA) in primary sclerosing cholangitis (PSC): Results after two years of a randomized double-blind, placebo-controlled trial [abstr] Gut 40 suppl 1 1997 TH115
72. M. Nakagawa C. Colombo K.D.R. Setchell Comprehensive study of the biliary bile acid composition of patients with cystic fibrosis and associated liver disease before and after UDCA administration Hepatology 12 1990 322
73. H. Nittono A. Tokita M. Hayashi Ursodeoxycholic acid therapy in the treatment of biliary atresia Biomed Pharamacother 43 1989 37
74. Oude Elferink R.P.J. R. Ottenhoff van Wijland M. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse J Clin Invest 95 1995 31
75. J. Palma H. Reyes J. Ribalta Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy Hepatology 15 1992 1043
76. T. Patel S.F. Bronk G.J. Gores Increases of intracellular magnesium promote glycochenodexycholate-induced apoptosis in rat hepatocytes J Clin Invest 94 1994 2183
77. T. Patel G.J. Gores Inhibition of bile salt-induced hepatocyte apoptosis by the antioxidant Lazaroid U83836E Toxicol Appl Pharmacol 142 1997 116
78. J.N. Plevris P.C. Hayes I.A.D. Bouchier Ursodeoxycholic acid in the treatment of alcoholic liver disease Eur J Gastroenterol Hepatol 3 1991 653
79. M. Podda C. Ghezzi P.M. Battezzati Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis Gastroenterology 98 1990 1044
80. J.L. Poo G. Feldmann S. Erlinger Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat Gastroenterology 102 1992 1752
81. R.E. Poupon B. Balkau E. Eschwege A multicenter controlled trial of ursodiol for the treatment of primary biliary cirrhosis N Engl J Med 324 1991 1548
82. R. Poupon Y. Chretien R. Poupon Serum bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid therapy Hepatology 17 1993 599
83. R. Poupon R.E. Poupon Y. Calmus Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis Lancet 1 1987 834
84. R.E. Poupon K.D. Lindor K. Cauch-Dudek Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis Gastroenterology 113 1997 884
85. L. Puglielli L. Amigo M. Arrese Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage Gastroenterology 107 1994 244
86. A. Roda F. Piazza M. Baraldini Taurohyodeoxycholic acid protects against hepatotoxicity induced by taurochenodeoxycholic acid in rat Hepatology 27 1998 520
87. E. Rolandi R. Franceschini A. Cataldi Effects of ursodeoxycholic acid on serum liver damage indices in patients with chronic active hepatitis Eur J Clin Pharmacol 40 1991 473
88. G. Rudolph R. Endele M. Senn Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis J Hepatol 17 1993 1028
89. F. Schliess A.K. Kurz vom Dahl S. Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver Gastroenterology 113 1997 1306
90. D.L. Schmucker M. Ohta S. Kanai Hepatic injury induced by bile salts: Correlation between biochemical and morphological events Hepatology 12 1990 1216
91. G.H. Shimokura J. McGill T. Schlenker Ursodeoxycholate increases cytosolic calcium concentration and activates CL currents in a biliary cell line Gastroenterology 109 1995 965
92. J.J.M. Smit A.H. Schinkel Oude Elferink R.P.J. Homozygous disruption of the murine mdr 2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Cell 75 1993 451
93. R.J. Sokol M. Devereaux R. Khandwala Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes Hepatology 17 1993 869
94. J.R. Spivey S.F. Bronk G.J. Gores Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes J Clin Invest 92 1993 17
95. A. Stiehl R. Raedsch G. Rudolph Ileal excretion of bile acids: Comparison with biliary bile acid composition and effect of ursodeoxycholic acid treatment Gastroenterology 94 1988 1201
96. A. Stiehl R. Raedsch G. Rudolph Acute effects of ursodeoxycholic acid and chenodeoxycholic acid on the small intestinal absorption of bile acids Gastroenterology 98 1990 424
97. A. Stiehl R. Raedsch G. Rudolph Effect of ursodeoxycholic acid on biliary bile acid and bile lipid composition in gallstone patients Hepatology 4 1984 107
98. A. Stiehl G. Rudolph R. Raedsch Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis Hepatology 12 1990 492
99. A. Stiehl G. Rudolph P. Sauer Efficacy of ursodeoxycholic acid and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis: An 8-year prospective study J Hepatol 26 1997 560
100. A. Stiehl G. Rudolph P. Sauer Biliary secretion of bile acids and lipids in primary sclerosing cholangitis: Influence of cholestasis and effect of ursodeoxycholic acid treatment J Hepatol 23 1995 283
101. A. Stiehl S. Walker L. Stiehl Effects of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis: A 3 year pilot study with a placebo-controlled study period J Hepatol 20 1994 57
102. H. Takikawa N. Sano M. Aiso Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol 17beta-glucuronide-induced cholestasis in rats J Gastroenterol Hepatol 12 1997 84
103. S. Taresaki Y. Nakanuma H. Ogino Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy Am J Gastroenterol 86 1991 1194
104. K. Tsukahara S. Kanai M. Ohta Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats Liver 13 1993 262
105. Van Nieuwkerk C.M.J. Oude Elferink R.P.J. A.K. Groen Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene Gastroenterology 111 1996 165
106. S. Walker G. Rudolph R. Raedsch Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage Gastroenterology 102 1992 810
107. M. Yoshikawa T. Tsujii K. Matsumura Immunomodulatory effects of ursodeoxycholic acid on immune responses Hepatology 16 1992 358
108. X.M. Zhao A.M. Montet J.C. Montet β muricholic acid: A new hepatoprotective agent J Nutr Biochem 4 1993 105