Functional heterogeneity of the intrahepatic biliary epithelium

Hepatology

Volumn 31, Issue 3, 2000, Pages 555-561

  Kanno, Noriatsu ^b   LeSage, Gene ^a   Glaser, Shannon ^a   Alvaro, Domenico ^d   Alpini, Gianfranco ^a,b,c,e  

^a TEXAS A AND M UNIVERSITY   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c Ctrl Texas Vet Health Care System   (United States)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AMYLASE; CARBON TETRACHLORIDE; CYTOSOL AMINOPEPTIDASE; DIMETHYLNITROSAMINE DEMETHYLASE; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; PROTEIN BCL 2; SECRETIN; SOMATOSTATIN RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRIACYLGLYCEROL LIPASE; TRYPSIN;

CELL PROLIFERATION; CELL SECRETION; EPITHELIUM; HUMAN; INTRAHEPATIC BILE DUCT; LIVER INJURY; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 0034004712     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510310302     Document Type: Review

References (21)

1. Schaffner F, Popper H. Electron microscopic studies of normal and proliferated bile ductules. Am J Pathol 1961;38:393-410.
2. Alpini G, Phillips JO, LaRusso NF. The biology of the biliary epithelia. In: Arias I, Boyer J, Fausto N, Jakoby W, Schachter D, Shafritz DA, eds. The Liver; Biology & Pathobiology, 3rd ed. New York, Raven Press, 1994: 623-653.
3. Alpini G, Lenzi R, Sarkozi L, Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 1988;81:569-578.
4. Alpini G, Ulrich II C, Phillips J, Pham L, Miller L, LaRusso N. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol 1994;266:G922-G928.
5. Alpini G, Glaser S, Robertson W, Rodgers R, Phinizy JL, Lasater J, LeSage GD. Large but not small intrahepatic bile duct units are involved in secretin-regulated ductal bile secretion in normal rat liver. Am J Physiol 1997;272:G1064-G1074.
6. Alvaro D, Cho WKC, Mennone A, Boyer JL. Effect of secretin on intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest 1993;92:1314-1325.
7. Glaser S, Rodgers R, Phinizy JL, Robertson W, Lasater J, Caligiuri J, Tretjak Z, et al. Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. Am J Physiol 1997:273:G1061-G1070.
8. LeSage G, Glaser S, Gubba S, Robertson WE, Phinizy JL, Lasater J, Rodgers R, et al. Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal bile secretion. Gastroentrology 1996;111:1633-1644.
9. Tietz P, Alpini G, Pham LD, LaRusso NF. Somatostatin inhibits secretin-induced ductal choleresis in vivo and exocytosis by cholangiocytes. Am J Physiol 1995;269:G110-G118.
10. Alpini G, Lenzi R, Zhai W-R, Slott PA, Liu MH, Sarkozi L, Tavoloni N. Bile secretory function of intrahepatic biliary epithelium in the rat. Am J Physiol 1989;257:G124-G133.
11. Cho WK, Mennone A, Rydberg SA, Boyer JL. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: implications for neural regulation of bile secretion. Gastroenterology 1997;113:311-321.
12. Caligiuri A, Glaser S, Rodgers R, Phinizy JL, Robertson W, Papa E, Pinzani M, et al. Endothelin l inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes. Am J Physiol 1998;275:G835-G846.
13. Alvaro D, Alpini G, Jezequel AM, Bassotti C, Francis C, Fraioli F, Romeo R, et al. Role and mechanisms of acetylcholine in the regulation of cholangiocyte secretory functions. J Clin Invest 1997;100:1349-1362.
14. Martinez-Anso E, Castillo JE, Diez J, Medina JF, Prieto J. Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver. HEPATOLOGY 1994;19:1400-1406.
15. Alpini G, Roberts SK, Kuntz SM, Ueno Y, Gubba S, Podila P, LeSage G, et al. Morphologic, molecular and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology 1996;110:1637-1643.
16. Alpini G, Ulrich C, Roberts SK, Phillips JO, Ueno Y, Podila P, Colegio O, et al. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 1997;273:G289-G297.
17. - exchange in cholangiocytes. Am J Physiol 1997;273:G303-G313.
18. Fitz JG, Basavappa S, McGill J, Melhus O, Cohn JA. Regulation of membrane chloride currents in rat bile duct epithelial cells. J Clin Invest 1993;91:319-328.
19. McGill JM, Basavappa S, Gettys TW, Fitz JG. Secretin activates Cl-channels in bile duct epithelial cells through a cAMP-dependent mechanism. Am J Physiol 1994;266:G731-G736.
20. Strazzabosco M, Mennone A, Boyer JL. Intracellular pH regulation in isolated rat bile duct cells. J Clin Invest 1991;87:1503-1512.
21. Tsuruoka S, Takeda M, Yoshitomo K, Imai M. Cellular heterogeneity of ammonium ion transport across the basolateral membrane of the hamster medullar thick ascending limb of Henle's loop. J Clin Invest 1993;92:1881-1888.