-
1
-
-
0342652540
-
Analytical studies and murine pharmacokinetics of cosalane
-
Bigelow J, Mathews L, Chrin L, Horton P and McCormack J (1994) Analytical studies and murine pharmacokinetics of cosalane. Proc Am Assn Cancer Res 35:427.
-
(1994)
Proc Am Assn Cancer Res
, vol.35
, pp. 427
-
-
Bigelow, J.1
Mathews, L.2
Chrin, L.3
Horton, P.4
McCormack, J.5
-
2
-
-
0029588280
-
Membrane permeability and lipophilicity in the isolated perfused rat liver: 5-Ethyl barbiluric acid and other compounds
-
Chou C-H. McLachlan AJ and Rowland M (1995) Membrane permeability and lipophilicity in the isolated perfused rat liver: 5-Ethyl barbiluric acid and other compounds. J Pharmacol Exp Ther 275:933-940.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 933-940
-
-
Chou, C.-H.1
McLachlan, A.J.2
Rowland, M.3
-
3
-
-
0018398718
-
A pharmacokinetic model for enterohepatic recirculation in the rat: Phenolphthalein, a model drug
-
Colburn WA, Hirom PC, Parker RJ and Milburn P (1979) A pharmacokinetic model for enterohepatic recirculation in the rat: Phenolphthalein, a model drug. Drug Metab Dispos 7:100-102.
-
(1979)
Drug Metab Dispos
, vol.7
, pp. 100-102
-
-
Colburn, W.A.1
Hirom, P.C.2
Parker, R.J.3
Milburn, P.4
-
4
-
-
0027996494
-
Design, synthesis and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction
-
Cushman M, Golebiewski WM, McMohan JB, Buckheit RW Jr, Clanton DJ, Weislow O, Haugwitz RD, Bader JP, Graham L and Rice WG (1994) Design, synthesis and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J Med Chem 37:3040-3050.
-
(1994)
J Med Chem
, vol.37
, pp. 3040-3050
-
-
Cushman, M.1
Golebiewski, W.M.2
McMohan, J.B.3
Buckheit R.W., Jr.4
Clanton, D.J.5
Weislow, O.6
Haugwitz, R.D.7
Bader, J.P.8
Graham, L.9
Rice, W.G.10
-
5
-
-
0029065930
-
Cosalane analogues with enhanced potencies as inhibitors of HIV-I protease integrase
-
Cushman M, Golebiewski WM, Pommier Y, Mazumder A, Reymen D, De Clercq E, Graham L and Rice WG (1995) Cosalane analogues with enhanced potencies as inhibitors of HIV-I protease integrase. J Med Chem 38:443-452.
-
(1995)
J Med Chem
, vol.38
, pp. 443-452
-
-
Cushman, M.1
Golebiewski, W.M.2
Pommier, Y.3
Mazumder, A.4
Reymen, D.5
De Clercq, E.6
Graham, L.7
Rice, W.G.8
-
6
-
-
0030952475
-
Biliary excretion and enterohepatic cycling of R- and S-flurbiprofen in the rat
-
Eeckhoudt SL, Evard PA and Verbeeck RK (1997) Biliary excretion and enterohepatic cycling of R- and S-flurbiprofen in the rat. Drug Metab Dispos 25:428-430.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 428-430
-
-
Eeckhoudt, S.L.1
Evard, P.A.2
Verbeeck, R.K.3
-
7
-
-
0020963903
-
Physiologically based pharmacokinetic modeling: Principles and applications
-
Gerlowski LE and Jain RK (1983) Physiologically based pharmacokinetic modeling: Principles and applications. J Pharm Sci 72:1103-1127.
-
(1983)
J Pharm Sci
, vol.72
, pp. 1103-1127
-
-
Gerlowski, L.E.1
Jain, R.K.2
-
9
-
-
0030272456
-
Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues
-
Golebiewski WM, Keyes RF and Cushman M (1996) Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorg Med Chem 4:1637-1648.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 1637-1648
-
-
Golebiewski, W.M.1
Keyes, R.F.2
Cushman, M.3
-
10
-
-
0015405449
-
Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions
-
Hirom PC, Millburn P, Smith RL and Williams RT (1972) Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions. Biochem J 129:1071-1077.
-
(1972)
Biochem J
, vol.129
, pp. 1071-1077
-
-
Hirom, P.C.1
Millburn, P.2
Smith, R.L.3
Williams, R.T.4
-
11
-
-
0030033216
-
Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements
-
Keyes RF, Golebiewski WM and Cushman M (1996) Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements. J Med Chem 39:508-514.
-
(1996)
J Med Chem
, vol.39
, pp. 508-514
-
-
Keyes, R.F.1
Golebiewski, W.M.2
Cushman, M.3
-
12
-
-
0019422355
-
A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry
-
Martin YC (1981) A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry. J Med Chem 24:229-237.
-
(1981)
J Med Chem
, vol.24
, pp. 229-237
-
-
Martin, Y.C.1
-
13
-
-
24544470049
-
Effect of protein binding and membrane partitioning on transcellular permeability of highly lipophilic novel anti-HIV agent cosalane across Caco-2 cell monolayers
-
Pal D, Udata C and Mitra AK (1998) Effect of protein binding and membrane partitioning on transcellular permeability of highly lipophilic novel anti-HIV agent cosalane across Caco-2 cell monolayers. Pham Sci Suppl 1:S93.
-
(1998)
Pham Sci Suppl
, vol.1
-
-
Pal, D.1
Udata, C.2
Mitra, A.K.3
-
14
-
-
0025891467
-
Physiologic and metabolic influences on enterohepatic recirculation: Simulations based upon the disposition of valproic acid in the rat
-
Pollack GM and Brouwer LR (1991) Physiologic and metabolic influences on enterohepatic recirculation: Simulations based upon the disposition of valproic acid in the rat. J Pharmcokinet Biopharm 19:189-225.
-
(1991)
J Pharmcokinet Biopharm
, vol.19
, pp. 189-225
-
-
Pollack, G.M.1
Brouwer, L.R.2
-
15
-
-
0001866079
-
Physiologic models of hepatic elimination
-
(Rescigno A and Thakur AK) Plenum Press, New York
-
Rowland M and Evans AM (1991) Physiologic models of hepatic elimination, in new Trends in Pharmacokinetics (Rescigno A and Thakur AK) pp 83-102. Plenum Press, New York.
-
(1991)
New Trends in Pharmacokinetics
, pp. 83-102
-
-
Rowland, M.1
Evans, A.M.2
-
16
-
-
0343958560
-
Movement through membranes
-
(Rowland M and Tozer TN eds.) Lea & Febiger, Philadelphia
-
Rowland M and Tozer TN (1989) Movement through membranes, in Clinical Pharmacokinetics (Rowland M and Tozer TN eds.) pp 103-112, Lea & Febiger, Philadelphia.
-
(1989)
Clinical Pharmacokinetics
, pp. 103-112
-
-
Rowland, M.1
Tozer, T.N.2
-
17
-
-
0003577273
-
Factors affecting biliary excretion
-
(Smith RL ed) Chapman and Hall, London
-
Smith RL (1973) Factors affecting biliary excretion, in The Excretory Function of Bile (Smith RL ed) pp 16-34, Chapman and Hall, London.
-
(1973)
The Excretory Function of Bile
, pp. 16-34
-
-
Smith, R.L.1
-
18
-
-
0019807228
-
A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat
-
Tomlinson PW, Jeffery DJ and Filer CW (1981) A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat. Xenobiotica 11:863-870.
-
(1981)
Xenobiotica
, vol.11
, pp. 863-870
-
-
Tomlinson, P.W.1
Jeffery, D.J.2
Filer, C.W.3
-
19
-
-
0032770434
-
Disposition of cosalane in isolated perfused rat livers
-
Udata C, Mitra AK and Badr MZ (1999) Disposition of cosalane in isolated perfused rat livers. Drug Metab Dispos 27:947-950.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 947-950
-
-
Udata, C.1
Mitra, A.K.2
Badr, M.Z.3
-
20
-
-
0029969048
-
Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586). An extremely hydrophobic diprotic acid
-
Venkatesh S, Li J, Xu Y, Vishnuvajjala R and Anderson BD (1996) Intrinsic solubility estimation and pH-solubility behavior of cosalane (NSC 658586). an extremely hydrophobic diprotic acid. Pharm Res 13:1453-1459.
-
(1996)
Pharm Res
, vol.13
, pp. 1453-1459
-
-
Venkatesh, S.1
Li, J.2
Xu, Y.3
Vishnuvajjala, R.4
Anderson, B.D.5
-
22
-
-
0021858187
-
The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
-
Wisse E, De Zanger RB, Charels P. Van Der Smissen P and McCuskey RS (1985) The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 5:683-692.
-
(1985)
Hepatology
, vol.5
, pp. 683-692
-
-
Wisse, E.1
De Zanger, R.B.2
Charels, P.3
Van Der Smissen, P.4
McCuskey, R.S.5
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