Murine neonatal lymphocytes show rapid early cell cycle entry and cell division

Journal of Immunology

Volumn 170, Issue 9, 2003, Pages 4548-4556

  Adkins, Becky ^a   Williamson, Tonya ^a   Guevara, Patricia ^a   Bu, Yurong ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; IONOMYCIN; PHENYLMERCAPTURIC ACID; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL KINETICS; COMPARATIVE STUDY; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; IMMUNE RESPONSE; IMMUNOLOGICAL MEMORY; LYMPH NODE CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; UPREGULATION;

EID: 0037406715     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.9.4548     Document Type: Article

References (42)

1. Forsthuber, T., H. C. Yip, and P. V. Lehmann. 1996. Induction of Th1 and Th2 immunity in neonatal mice. Science 217:1728.
2. Ridge, J. P., E. J. Fuchs, and P. Matzinger. 1996. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271:1723.
3. Sarzotti, M., D. S. Robbins, and P. M. Hoffman. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
4. A-bearing accessory cells are found early in the thymus but late in the spleen. Proc. Natl. Acad. Sci. USA 77:1597.
5. Levin, D., and H. Gershon. 1989. Antigen presentation by neonatal murine spleen cells. Cell. Immunol. 120:132.
6. Goriely, S., B. Vincart, P. Stordeur, J. Vekemans, F. Willems, M. Goldman, and D. De Wit. 2001. Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes. J. Immunol. 166:2141.
7. Muthukkumar, S., J. Goldstein, and K. E. Stein. 2000. The ability of B cells and dendritic cells to present antigen increases during ontogeny. J. Immunol. 165:4803.
8. Adkins, B. 2000. Development of neonatal Th1/Th2 function. Int. Rev. Immunol. 19:157.
9. Garcia, A. M., S. A. Fadel, S. Cao, and M. Sarzotti. 2000. T cell immunity in neonates. Immunol. Res. 22:177.
10. Siegrist, C. A. 2000. Vaccination in the neonatal period and early infancy. Int. Rev. Immunol. 19:195.
11. Adkins, B., and R.-Q. Du. 1998. Newborn mice develop balanced Th1/Th2 primary effector responses in vivo but are biased to Th2 secondary responses. J. Immunol. 160:4217.
12. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
13. Adkins, B., and K. Hamilton. 1992. Freshly isolated, murine neonatal T cells produce IL-4 in response to anti-CD3 stimulation. J. Immunol. 149:3448.
14. lo thymocytes in vivo. Science 250:1720.
15. Adkins. B. 1991. Developmental regulation of the intrathymic T cell precursor population. J. Immunol. 146:1387.
16. Adkins, B., K. Chun, K. Hamilton, and M. Nassiri. 1996. Naive murine neonatal T cells undergo apoptosis in response to primary stimulation. J. Immunol. 157:1343.
17. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
18. Gett, A. V., and P. D. Hodgkin. 1998. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation. Proc. Natl. Acad. Sci. USA 95:9488.
19. Wells, A. D., M. C. Walsh, D. Sankaran, and L. A. Turka. 2000. T cell effector function and anergy avoidance are quantitatively linked to cell division. J. Immunol. 165:2432.
20. Foulds, K. E., L. A. Zenewicz, D. J. Shedlock, J. Jiang, A. E. Troy, and H. Shen. 2002. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J. Immunol. 168:1528.
21. Shapiro, H. M. 1981. Flow cytometric estimation of DNA and RNA content in intact cells stained with Hoechst 33342 and pyronin Y. Cytometry 2:143.
22. Darzynkiewicz, Z., D. P. Evenson, L. Staiano-Coico, T. K. Sharpless, and M. L. Melamed. 1979. Correlation between cell cycle duration and RNA content. J. Cell Physiol. 100:425.
23. Darzynkiewicz, Z. 1988. Cellular RNA content, a feature correlated with cell kinetics and tumor prognosis. Leukemia 2:777.
24. Surh, C. D., and J. Sprent. 2000. Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? J. Exp. Med. 192:F9.
25. Prlic, M., and S. C. Jameson. 2002. Homeostatic expansion versus antigen-driven proliferation: common ends by different means? Microbes Infect. 4:531.
26. Richter, A., M. Lohning, and A. Radbruch. 1999. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J. Exp. Med. 190:1439.
27. Ben-Sasson, S. Z., R. Gerstel, J. Hu-Li, and W. E. Paul. 2001. Cell division is not a "clock" measuring acquisition of competence to produce IFN-γ or IL-4. J. Immunol. 166:112.
28. Takemoto, N., N. Koyano-Nakagawa, T. Yokota, N. Arai, S. Miyatake, and K. Arai. 1998. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int. Immunol. 10:1981.
29. Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9:765.
30. H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3:643.
31. Fields, P. E., S. T. Kim, and R. A. Flavell. 2002. Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J. Immunol. 169:647.
32. + cells in human fetal bone marrow. Early Hum. Dev. 65:159.
33. Yong, K. L., A. Fahey, G. Pahal, D. C. Linch, A. Pizzey, N. S. Thomas, E. Jauniaux, C. Kinnon, and A. J. Thrasher. 2002. Fetal haemopoietic cells display enhanced migration across endothelium. Br. J. Haematol. 116:392.
34. 1/S phase transition in vitro. In Vitro Cell. Dev. Biol. Anim. 35:410.
35. McKilligin, E., and D. J. Grainger. 2001. Cell volume and rate of proliferation, but not protein expression pattern, distinguish pup/intimal smooth muscle cells from subcultured adult smooth muscle cells. Cell Prolif. 34:275.
36. Hassan, J., and D. J. Reen. 2001. Human recent thymic emigrants - identification, expansion, and survival characteristics. J. Immunol. 167:1970.
37. + T cells. Proc. Natl. Acad. Sci. USA 98:9277.
38. Le Campion, A., C. Bourgeois, F. Lambolez, B. Martin, S. Leaument, N. Dautigny, C. Tanchot, C. Penit, and B. Lucas. 2002. Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes. Proc. Natl. Acad. Sci. USA 99:4538.
39. Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion: signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100:3173.
40. 1 to S phase transition by adhesion and growth factor signaling. In Steroid Hormones and Cell Cycle Regulation. K. Burnstein, ed. Kluwer Academic, New York, p. 19.
41. 1 cyclin-dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol. 12:676.
42. Samelson, L. E. 2002. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20:371.