5-Azacytidine reactivates the erythroid differentiation potential of the myeloid-restricted murine cell line 32D Ro

Experimental Cell Research

Volumn 285, Issue 2, 2003, Pages 258-267

  Baiocchi, Marta ^a   Di Rico, Cristina ^a   Di Pietro, Roberta ^b   Di Baldassarre, Angela ^b   Migliaccio, Anna Rita ^a,b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

32D cell line; 5 Azacytidine; Erythroid differentiation; Methylation; Stem cell plasticity

Indexed keywords

ALPHA GLOBIN; AZACITIDINE; BETA GLOBIN; COLONY STIMULATING FACTOR 1; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; INHIBITOR OF DIFFERENTIATION PROTEIN; INTERLEUKIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR NEF2; TRANSCRIPTION FACTOR SCL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CLONE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; ERYTHROCYTE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION;

MURINAE;

EID: 0037403646     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00032-6     Document Type: Article

References (57)

1. McCulloch E.A. Stem cells in normal and leukemic hemopoiesis. Blood. 62:1983;1-13.
2. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 81:1993;2844-2853.
3. Akashi K., Traver D., Miyamoto T., Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 404:2000;193-197.
4. Orkin S.H. Transcription factors that regulate lineage decision. Stamatoyannopoulos G., Majerus P.W., Perlmutter R., Varmus H. The Molecular Basis of Blood Diseases. 2001;Saunders, Philadelphia.
5. Enver T., Greaves M. Loops, lineage, and leukemia. Cell. 94:1998;9-12.
6. Singal R., Ginder G.D. DNA methylation. Blood. 93:1999;4059-4070.
7. Migliaccio G., Migliaccio A.R., Adamson J.W. The biology of hematopoietic growth factors studies in vitro under serum-deprived conditions . Exp. Hematol. 18:1990;1049-1055.
8. Phillips R.L., Ernst R.E., Brunk B., Ivanova N., Mahan M.A., Deanehan J.K., Moore K.A., Overton G.C., Lemischka I.R. The genetic program of hematopoietic stem cells. Science. 288:2000;1635-1640.
9. Greenberger J.S., Sakakeeny M.A., Humphries R.K., Eaves C.J., Eckner R.J. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl. Acad. Sci. USA. 80:1983;2931-2935.
10. Dexter T.M., Garland J., Scott D., Scolnick E., Metcalf D. Growth of factor-dependent hemopoietic precursor cell lines. J. Exp. Med. 152:1980;1036-1047.
11. Migliaccio G., Migliaccio A.R., Kreider B.L., Rovera G., Adamson J.W. Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. J. Cell Biol. 109:1989;833-841.
12. Valtieri M., Tweardy D.J., Caracciolo D., Johnson K., Mavilio F., Altmann S., Santoli D., Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 138:1987;3829-3835.
13. Kreider B.L., Phillips P.D., Prystowsky M.B., Shirsat N., Pierce J.H., Tushinski R., Rovera G. Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell. Mol. Cell Biol. 10:1990;4846-4853.
14. Kreider B.L., Benezra R., Rovera G., Kadesch T. Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Science. 255:1992;1700-1702.
15. Taylor S.M., Jones P.A. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell. 17:1979;771-779.
16. Jones P.A., Wolkowicz M.J., Rideout W.M., Gonzales F.A., Marziasz C.M., Coetzee G.A., Tapscott S.J. De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc. Natl. Acad. Sci. USA. 87:1990;6117-6121.
17. Migliaccio G., Migliaccio A.R., Kaushansky K., Adamson J.W. Regulation of differentiation of murine progenitor cells derived from blast cell colonies under serum-deprived conditions. Exp. Hematol. 17:1989;110-115.
18. Migliaccio G., Migliaccio A.R., Visser J.W. Synergism between erythropoietin and interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst colony formation. Blood. 72:1988;944-951.
19. Chomcynski P., Sacchi N. Single-step method of RNA isolated by acid guanidinium thiocyanate-phenol-chloroform extraction. Annu. Rev. Biochem. 162:1987;156-159.
20. Ashihara E., Vannucchi A.M., Migliaccio G., Migliaccio A.R. Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells. J. Cell Physiol. 171:1997;343-356.
21. Vannucchi A.M., Paoletti F., Linari S., Cellai C., Caporale R., Ferrini P.R., Sanchez M., Migliaccio G., Migliaccio A.R. Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood. 95:2000;2559-2568.
22. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning A Laboratory Manual . 2nd ed:1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
23. Begley C.G., Visvader J., Green A.R., Aplan P.D., Metcalf D., Kirsch I.R., Gough N.M. Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL. Proc. Natl. Acad. Sci. USA. 88:1991;869-873.
24. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id a negative regulator of helix-loop-helix DNA binding proteins . Cell. 61:1990;49-59.
25. Tsai S.F., Martin D.I., Zon L.I., D'Andrea A.D., Wong G.G., Orkin S.H. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 339:1989;446-451.
26. Tsai F.Y., Keller G., Kuo F.C., Weiss M., Chen J., Rosenblatt M., Alt F.W., Orkin S.H. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371:1994;221-226.
27. Miller I.J., Bieker J.J. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol. Cell Biol. 13:1993;2776-2786.
28. Chan J.Y., Han X.L., Kan Y.W. Isolation of cDNA encoding the human NF-E2 protein. Proc. Natl. Acad. Sci. USA. 90:1993;11366-11370.
29. D'Andrea A.D., Lodish H.F., Wong G.G. Expression cloning of the murine erythropoietin receptor. Cell. 57:1989;277-285.
30. Ramsay R.G., Ikeda K., Rifkind R.A., Marks P.A. Changes in gene expression associated with induced differentiation of erythroleukemia protooncogenes, globin genes, and cell division . Proc. Natl. Acad. Sci. USA. 83:1986;6849-6853.
31. Orkin S.H., Harosi F.I., Leder P. Differentiation in erythroleukemic cells and their somatic hybrids. Proc. Natl. Acad. Sci. USA. 72:1975;98-102.
32. Hu M., Krause D., Greaves M., Sharkis S., Dexter M., Heyworth C., Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11:1997;774-785.
33. Eglitis M.A., Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl. Acad. Sci. USA. 94:1997;4080-4085.
34. Ferrari G., Cusella-De A.G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F. Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 279:1998;1528-1530.
35. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., Pickel J., McKay R., Nadal-Ginard B., Bodine D.M., Leri A., Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature. 410:2001;701-705.
36. Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I.L., Grompe M. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6:2000;1229-1234.
37. Almeida-Porada G., Porada C., Zanjani E.D. Adult stem cell plasticity and methods of detection. Rev. Clin. Exp. Hematol. 5:2001;26-41.
38. Zon L.I., Youssoufian H., Mather C., Lodish H.F., Orkin S.H. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc. Natl. Acad. Sci. USA. 88:1991;10638-10641.
39. Chiba T., Ikawa Y., Todokoro K. GATA-1 transactivates erythropoietin receptor gene, and erythropoietin receptor-mediated signals enhance GATA-1 gene expression. Nucleic Acids Res. 19:1991;3843-3848.
40. Tsai S.F., Strauss E., Orkin S.H. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 5:1991;919-931.
41. Baron M.H., Farrington S.M. Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells. Mol. Cell Biol. 14:1994;3108-3114.
42. Pevny L., Simon M.C., Robertson E., Klein W.H., Tsai S.F., D'Agati V., Orkin S.H., Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349:1991;257-260.
43. Tsang A.P., Fujiwara Y., Hom D.B., Orkin S.H. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 12:1998;1176-1188.
44. Crotta S., Nicolis S., Ronchi A., Ottolenghi S., Ruzzi L., Shimada Y., Migliaccio A.R., Migliaccio G. Progressive inactivation of the expression of an erythroid transcriptional factor in GM- and G-CSF-dependent myeloid cell lines. Nucleic Acids Res. 18:1990;6863-6869.
45. Shivdasani R.A., Fujiwara Y., McDevitt M.A., Orkin S.H. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 16:1997;3965-3973.
46. Yu C., Cantor A.B., Yang H., Browne C., Wells R.A., Fujiwara Y., Orkin S.H. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J. Exp. Med. 195:2002;1387-1395.
47. Migliaccio A.R.Rana, Sanchez R.A., Lorenzini M., Centurione R., Bianchi L., Vannucchi L., Migliaccio G.A.M. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-low mouse mutant. J. Exp. Med. 197:2003;281-296.
48. McDevitt M.A., Shivdasani R.A., Fujiwara Y., Yang H., Orkin S.H. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc. Natl. Acad. Sci. USA. 94:1997;6781-6785.
49. Vannucchi A., Linari S., Lin C.-S., Koury M., Bondurant M., Migliaccio A.R. Increased expression of the distal, but not of the proximal Gata1 transcripts during differentiation of erythroid cells. J. Cell Phys. 180:1999;390-401.
50. Kulessa H., Frampton J., Graf T. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev. 9:1995;1250-1262.
51. Farina S.F., Girard L.J., Vanin E.F., Nienhuis A.W., Bodine D.M. Dysregulated expression of GATA-1 following retrovirus-mediated gene transfer into murine hematopoietic stem cells increases erythropoiesis. Blood. 86:1995;4124-4133.
52. McNagny K., Graf T. Making eosinophils through subtle shifts in transcription factor expression. J. Exp. Med. 195:2002;F43-F47.
53. Metcalf D., Enver T., Heyworth C.M., Dexter T.M. Lineage commitment and maturation in hematopoietic cells. The case for extrinsic regulation. Do stem cells play dice? Blood. 92:1998;345-348.
54. Beru N., Maples P.B., Hermine O., Goldwasser E. Differential expression of alpha- and beta-globin genes in erythroleukemic cell lines. Mol. Cell Biol. 10:1990;3591-3595.
55. Migliaccio A.R., Migliaccio G., D'Andrea A., Baiocchi M., Ronchi A., Nicolis S., Ottolenghi S., Adamson J.W. Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface. Proc. Natl. Acad. Sci. USA. 88:1991;11086-11090.
56. Koury M.J., Bondurant M.C. Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science. 248:1990;378-381.
57. Spivak J.L., Pham T., Isaacs M., Hankins W.D. Erythropoietin is both a mitogen and a survival factor. Blood. 77:1991;1228-1233.