Dominant-negative TAK1 induces c-Myc and G0 exit in liver

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 281, Issue 5 44-5, 2001, Pages

  Bradham, Cynthia A ^a   Hatano, Etsuro ^a   Brenner, David A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

c Jun NH2 terminal kinase; Partial hepatectomy; Proliferation; Transforming growth factor

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; LIVER REGENERATION; LIVER RESECTION; MALE; MITOSIS; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RAT; VIRUS RECOMBINANT;

EID: 0035200383     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.281.5.g1279     Document Type: Article

References (94)

1. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy
2. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver
3. Transient induction of c-Jun during hepatic regeneration
4. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes
5. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
6. Hepatic steatosis as a potential risk factor for major hepatic resection
7. 1 arrest through reduction of cyclin E/CDK2 kinase activity
8. 0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors
9. The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells
10. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells
11. The mitochondrial permeability transition is required for TNF-α-mediated apoptosis and cytochrome c release
12. Liver disease and compensatory growth: Unexpected lessons from genetically altered mice
13. Transforming growth factor beta mRNA increases during liver regeneration: A possible paracrine mechanism of growth regulation
14. Suppression of oncogene-induced transformation by a deletion mutant of c-jun
15. Mechanism of action of a dominant negative mutant of c-Jun
16. Expression of catenins during mouse embryonic development and in adult tissues
17. The G-C specific DNA binding drug, mithramycin, selectively inhibits transcription of the C-MYC and C-HARAS genes in regenerating liver
18. TRAF6 is a signal transducer for interleukin-1
19. 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent caco- 2 cell differentiation
20. Activin A-induced HepG2 liver cell apoptosis: Involvement of activin receptors and smad proteins
21. Differences in the steady-state levels of c-fos, c-jun and c-myc messenger RNA during mitogen-induced liver growth and compensatory regeneration
22. Hepatic steatosis: Innocent bystander or guilty party?
23. Relationship between hepatocyte proliferative activity and liver functional reserve in human cirrhosis
24. JNK-1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
25. Defective T cell differentiation in the absence of Jnk1
26. Cell cycle-mediated regulation of hepatic regeneration
27. Suppression of the EGF-dependent induction of c-myc protooncogene expression by transforming growth factor beta in a human breast carcinoma cell line
28. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration
29. Manipulation of adenovirus vectors
30. Effects of c-myc expression on cell cycle progression
31. Identification of c-MYC as a target of the APC pathway
32. TGF-beta signalling from cell membrane to nucleus through SMAD proteins
33. Restoration of the liver of the white rat following partial surgical removal
34. c-Jun is essential for normal mouse development and hepatogenesis
35. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
36. Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomas
37. NFκB prevents apoptosis and liver dysfunction during liver regeneration
38. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF
39. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
40. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
41. Molecular cloning of human TAK1 and its mutational analysis in human lung cancer
42. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascades
43. In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway
44. Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration
45. Induction of cyclin mRNA and cyclin-associated histone H1 kinase during liver regeneration
46. c-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment
47. Sensitivity to transforming growth factor beta 1-induced growth arrest is common in human squamous cell carcinoma cell lines: c-MYC down-regulation and p21waf1 induction are important early events
48. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
49. Liver regeneration: Molecular mechanisms of growth control
50. 1 to S phase cell cycle progression on both Ras/mitogen-activated protein kinase and Ras/Rac1/Jun N-terminal kinase cascades in NIH 3T3 fibroblasts
51. Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA- 4
52. Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis
53. Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
54. Evidence for c-myc in the signaling pathway for TGF-beta in well-differentiated human colon carcinoma cells
55. Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis
56. Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development
57. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL- 1 signalling pathway
58. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase
59. Regulation of glomerular mesangial cell proliferation in culture by adrenomedullin
60. Specificity, diversity, and regulation in TGF-beta superfamily signaling
61. TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
62. Time course comparison of cell-cycle protein expression following partial hepatectomy and WY14,643-induced hepatic cell proliferation in F 344 rats
63. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
64. Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat
65. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation
66. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism
67. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
68. Failure of regeneration of the steatotic rat liver: Disruption at two different levels in the regeneration pathway
69. 1 transition in nontransformed cells
70. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
71. Adenovector-mediated gene transfer of active transforming growth factor-beta 1 induces prolonged severe fibrosis in rat lung
72. A role for JNK/SAPK in proliferation, but not apoptosis, of IL3-dependent cells
73. Regulation of cell cycle-related genes in rat hepatocytes by transforming growth factor beta 1
74. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL- 1 signal transduction pathway
75. Fos/jun and octamer-binding protein interact with a common site in a negative element of the human c-myc gene
76. Transforming growth factor-beta 1 is a new form of tumor suppressor with true haploid insufficiency
77. TGF-beta-activating kinase-1 inhibits cell cycle and expression of cyclin D1 and A in LLC-PK1 cells
78. Dysregulation of apoptosis in hepatocellular carcinoma
79. Hepatocyte growth factor gene therapy of liver cirrhosis in rats
80. Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway
81. In vivo response of hepatocytes to growth factors requires an initial priming stimulus
82. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro and in vivo
83. Methods for analyzing c-Jun kinase
84. Activation of Jun kinase is an early event in hepatic regeneration
85. Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
86. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
87. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
88. Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells
89. + T cells to Th1 cells requires MAP kinase JNK2
90. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway
91. Tumor necrosis factor alpha gene regulation: Enhancement of C/EBPbeta-induced activation by c-Jun
92. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice
93. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade
94. Smad3 mutant mice develop metastatic colorectal cancer