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Volumn 315, Issue 1, 2003, Pages 1-21

Analysis of telomerase activity and detection of its catalytic subunit, hTERT

Author keywords

Detection techniques; hTERT; Telomerase; TRAP

Indexed keywords

CELL PROLIFERATION; TUMORS;

EID: 0037381762     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00663-2     Document Type: Review
Times cited : (66)

References (109)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell. Res. 25:1961;585-621.
    • (1961) Exp. Cell. Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov A.M. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41:1973;181-190.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 3
    • 0000980730 scopus 로고
    • Fusion of broken ends of chromosomes following nuclear fusion
    • McClintock B. Fusion of broken ends of chromosomes following nuclear fusion. Proc. Natl. Acad. Sci. USA. 28:1942;458-563.
    • (1942) Proc. Natl. Acad. Sci. USA , vol.28 , pp. 458-563
    • McClintock, B.1
  • 4
    • 0025731583 scopus 로고
    • Structure and function of telomeres
    • Blackburn E.H. Structure and function of telomeres. Nature. 350:1991;569-573.
    • (1991) Nature , vol.350 , pp. 569-573
    • Blackburn, E.H.1
  • 6
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 43:1985;405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 7
    • 0024978857 scopus 로고
    • A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
    • Greider C.W., Blackburn E.H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature. 337:1989;331-337.
    • (1989) Nature , vol.337 , pp. 331-337
    • Greider, C.W.1    Blackburn, E.H.2
  • 8
    • 0025021235 scopus 로고
    • Functional evidence for an RNA template in telomerase
    • Shippen-Lentz D., Blackburn E.H. Functional evidence for an RNA template in telomerase. Science. 247:1990;546-552.
    • (1990) Science , vol.247 , pp. 546-552
    • Shippen-Lentz, D.1    Blackburn, E.H.2
  • 12
    • 0031047426 scopus 로고    scopus 로고
    • Replicative senescence and cell immortality: The role of telomeres and telomerase
    • Chiu C.-P., Harley C.B. Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc. Soc. Exp. Biol. Med. 214:1997;99-106.
    • (1997) Proc. Soc. Exp. Biol. Med. , vol.214 , pp. 99-106
    • Chiu, C.-P.1    Harley, C.B.2
  • 14
    • 0032758167 scopus 로고    scopus 로고
    • At the end of the millennium, a view of the end
    • Shay J.W. At the end of the millennium, a view of the end. Nat. Genet. 23:1999;382-383.
    • (1999) Nat. Genet. , vol.23 , pp. 382-383
    • Shay, J.W.1
  • 15
    • 0035313820 scopus 로고    scopus 로고
    • Telomeric chromatin: Replicating and wrapping up chromosome ends
    • Shore D. Telomeric chromatin: replicating and wrapping up chromosome ends. Curr. Opin. Genet. Dev. 11:2001;189-198.
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 189-198
    • Shore, D.1
  • 16
    • 0032211413 scopus 로고    scopus 로고
    • Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends
    • Ancelin K., Brun C., Gilson E. Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends. Bioessays. 20:1998;879-883.
    • (1998) Bioessays , vol.20 , pp. 879-883
    • Ancelin, K.1    Brun, C.2    Gilson, E.3
  • 17
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B., Smogorzewska A., de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:1998;401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 18
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 19
    • 0037148330 scopus 로고    scopus 로고
    • Many ways to telomere dysfunction: In vivo studies using mouse models
    • Goytisolo F.A., Blasco M.A. Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene. 21:2002;584-591.
    • (2002) Oncogene , vol.21 , pp. 584-591
    • Goytisolo, F.A.1    Blasco, M.A.2
  • 21
    • 0034846018 scopus 로고    scopus 로고
    • Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells
    • Yang L., Suwa T., Wright W.E., Shay J.W., Hornsby P.J. Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells. Mech. Ageing Dev. 122:2001;1685-1694.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1685-1694
    • Yang, L.1    Suwa, T.2    Wright, W.E.3    Shay, J.W.4    Hornsby, P.J.5
  • 22
    • 0033957897 scopus 로고    scopus 로고
    • Telomeres, telomerase, and myc. An update
    • Cerni C. Telomeres, telomerase, and myc. An update. Mutat. Res. 462:2000;31-47.
    • (2000) Mutat. Res. , vol.462 , pp. 31-47
    • Cerni, C.1
  • 23
    • 0034006777 scopus 로고    scopus 로고
    • Role of telomerase in cell senescence and oncogenesis
    • Urquidi V., Tarin D., Goodison S. Role of telomerase in cell senescence and oncogenesis. Annu. Rev. Med. 51:2000;65-79.
    • (2000) Annu. Rev. Med. , vol.51 , pp. 65-79
    • Urquidi, V.1    Tarin, D.2    Goodison, S.3
  • 24
    • 0033581883 scopus 로고    scopus 로고
    • Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
    • Li H., Cao Y., Berndt M.C., Funder J.W., Liu J.P. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene. 18:1999;6785-6794.
    • (1999) Oncogene , vol.18 , pp. 6785-6794
    • Li, H.1    Cao, Y.2    Berndt, M.C.3    Funder, J.W.4    Liu, J.P.5
  • 26
    • 0033600896 scopus 로고    scopus 로고
    • In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells
    • Oh S., Song Y.H., Kim U.J., Yim J., Kim T.K. In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells. Biochem. Biophys. Res. Commun. 263:1999;361-365.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 361-365
    • Oh, S.1    Song, Y.H.2    Kim, U.J.3    Yim, J.4    Kim, T.K.5
  • 27
    • 0033934869 scopus 로고    scopus 로고
    • Telomerase activity and telomerase subunits gene expression patterns in neuroblastoma: A molecular and immunohistochemical study establishing prognostic tools for fresh-frozen and paraffin-embedded tissues
    • Poremba C., Scheel C., Hero B., Christiansen H., Schaefer K-L., Nakayama J-i., Berthold F., Juergens H., Boecker W., Dockhorn-Dwornniczak B. Telomerase activity and telomerase subunits gene expression patterns in neuroblastoma: a molecular and immunohistochemical study establishing prognostic tools for fresh-frozen and paraffin-embedded tissues. Clin. Oncol. 18:2000;2582-2592.
    • (2000) Clin. Oncol. , vol.18 , pp. 2582-2592
    • Poremba, C.1    Scheel, C.2    Hero, B.3    Christiansen, H.4    Schaefer, K.-L.5    Nakayama, J.-I.6    Berthold, F.7    Juergens, H.8    Boecker, W.9    Dockhorn-Dwornniczak, B.10
  • 30
    • 0035897568 scopus 로고    scopus 로고
    • Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)
    • Poole J.C., Andrews L.G., Tollefsbol T.O. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene. 269:2001;1-12.
    • (2001) Gene , vol.269 , pp. 1-12
    • Poole, J.C.1    Andrews, L.G.2    Tollefsbol, T.O.3
  • 33
    • 0032213488 scopus 로고    scopus 로고
    • Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia
    • Bechter O.E., Eisterer W., Pall G., Hilbe W., Kuhr T., Thaler J. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. Cancer Res. 58:1998;4918-4922.
    • (1998) Cancer Res. , vol.58 , pp. 4918-4922
    • Bechter, O.E.1    Eisterer, W.2    Pall, G.3    Hilbe, W.4    Kuhr, T.5    Thaler, J.6
  • 34
    • 0031869107 scopus 로고    scopus 로고
    • Telomere length dynamics in telomerase-positive immortal human cell populations
    • Bryan T.M., Englezou A., Dunham M.A., Reddel R.R. Telomere length dynamics in telomerase-positive immortal human cell populations. Exp. Cell. Res. 239:1998;370-378.
    • (1998) Exp. Cell. Res. , vol.239 , pp. 370-378
    • Bryan, T.M.1    Englezou, A.2    Dunham, M.A.3    Reddel, R.R.4
  • 35
    • 0031181266 scopus 로고    scopus 로고
    • Telomere length and telomerase activity in bladder and prostate cancer cell lines
    • Kageyama Y., Kamata S., Yonese J., Oshima H. Telomere length and telomerase activity in bladder and prostate cancer cell lines. Int. J. Urol. 4:1997;407-410.
    • (1997) Int. J. Urol. , vol.4 , pp. 407-410
    • Kageyama, Y.1    Kamata, S.2    Yonese, J.3    Oshima, H.4
  • 36
    • 0030453866 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and malignant haematologic cells
    • Leber B., Bacchetti S. Telomeres and telomerase in normal and malignant haematologic cells. Leuk. Lymphoma. 24:1996;1-9.
    • (1996) Leuk. Lymphoma , vol.24 , pp. 1-9
    • Leber, B.1    Bacchetti, S.2
  • 37
    • 0031204174 scopus 로고    scopus 로고
    • Telomere length and telomerase activity in carcinogenesis of the stomach
    • Maruyama Y., Hanai H., Fujita M., Kaneko E. Telomere length and telomerase activity in carcinogenesis of the stomach. Jpn. J. Clin. Oncol. 27:1997;216-220.
    • (1997) Jpn. J. Clin. Oncol. , vol.27 , pp. 216-220
    • Maruyama, Y.1    Hanai, H.2    Fujita, M.3    Kaneko, E.4
  • 38
    • 0032060718 scopus 로고    scopus 로고
    • Telomerase activity and telomere length as diagnostic tumor marker for ovarian tumors
    • Murakami J., Nagai N., Ohama K. Telomerase activity and telomere length as diagnostic tumor marker for ovarian tumors. Nippon Rinsho. 56:1998;1310-1315.
    • (1998) Nippon Rinsho , vol.56 , pp. 1310-1315
    • Murakami, J.1    Nagai, N.2    Ohama, K.3
  • 41
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright W.E., Tesmer V.M., Huffman K.E., Levene S.D., Shay J.W. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11:1997;2801-2809.
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 43
    • 0033836212 scopus 로고    scopus 로고
    • Expression of human telomerase subunit genes in primary lung cancer and its clinical significance
    • discussion 405-406
    • Arinaga M., Shimizu S., Gotoh K., Haruki N., Takahashi T., Mitsudomi T. Expression of human telomerase subunit genes in primary lung cancer and its clinical significance. Ann. Thorac. Surg. 70:2000;401-405. discussion 405-406.
    • (2000) Ann. Thorac. Surg. , vol.70 , pp. 401-405
    • Arinaga, M.1    Shimizu, S.2    Gotoh, K.3    Haruki, N.4    Takahashi, T.5    Mitsudomi, T.6
  • 44
    • 0034662113 scopus 로고    scopus 로고
    • Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomas
    • De Kok J.B., Schalken J.A., Aalders T.W., Ruers T.J., Willems H.L., Swinkels D.W. Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomas. Int. J. Cancer. 87:2000;217-220.
    • (2000) Int. J. Cancer , vol.87 , pp. 217-220
    • De Kok, J.B.1    Schalken, J.A.2    Aalders, T.W.3    Ruers, T.J.4    Willems, H.L.5    Swinkels, D.W.6
  • 46
    • 0035097792 scopus 로고    scopus 로고
    • Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues
    • Hiyama E., Hiyama K., Yokoyama T., Shay J.W. Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia. 3:2001;17-26.
    • (2001) Neoplasia , vol.3 , pp. 17-26
    • Hiyama, E.1    Hiyama, K.2    Yokoyama, T.3    Shay, J.W.4
  • 48
    • 0035515735 scopus 로고    scopus 로고
    • Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer
    • Lee B.K., Diebel E., Neukam F.W., Wiltfang J., Ries J. Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer. Int. J. Oncol. 19:2001;1063-1068.
    • (2001) Int. J. Oncol. , vol.19 , pp. 1063-1068
    • Lee, B.K.1    Diebel, E.2    Neukam, F.W.3    Wiltfang, J.4    Ries, J.5
  • 49
    • 0035031076 scopus 로고    scopus 로고
    • Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction
    • Schneider-Stock R., Emrich T., Peters B., Jaeger V., Roessner A. Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction. Electrophoresis. 22:2001;1098-1101.
    • (2001) Electrophoresis , vol.22 , pp. 1098-1101
    • Schneider-Stock, R.1    Emrich, T.2    Peters, B.3    Jaeger, V.4    Roessner, A.5
  • 50
    • 0035670157 scopus 로고    scopus 로고
    • Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients
    • Schrader M., Muller M., Heicappell R., Straub B., Miller K. Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients. Asian J. Androl. 3:2001;263-270.
    • (2001) Asian J. Androl. , vol.3 , pp. 263-270
    • Schrader, M.1    Muller, M.2    Heicappell, R.3    Straub, B.4    Miller, K.5
  • 51
    • 0036161231 scopus 로고    scopus 로고
    • Quantification of the expression level of the gene encoding the catalytic subunit of telomerase in testicular tissue specimens predicts successful sperm recovery
    • Schrader M., Muller M., Schulze W., Heicappell R., Krause H., Straub B., Miller K. Quantification of the expression level of the gene encoding the catalytic subunit of telomerase in testicular tissue specimens predicts successful sperm recovery. Hum. Reprod. 17:2002;150-156.
    • (2002) Hum. Reprod. , vol.17 , pp. 150-156
    • Schrader, M.1    Muller, M.2    Schulze, W.3    Heicappell, R.4    Krause, H.5    Straub, B.6    Miller, K.7
  • 52
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter C.M., Avilion A.A., LeFeuvre C.E., Stewart N.G., Greider C.W., Harley C.B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 53
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
    • Morin G.B. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:1989;521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 54
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter C.M., Botelho F.M., Wang P., Harley C.B., Bacchetti S. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68:1994;3410-3414.
    • (1994) J. Virol. , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Wang, P.3    Harley, C.B.4    Bacchetti, S.5
  • 55
    • 0029856991 scopus 로고    scopus 로고
    • Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit
    • Holt S.E., Norton J.C., Wright W.E., Shay J.W. Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit. Methods Cell. Sci. 18:1996;237-248.
    • (1996) Methods Cell. Sci. , vol.18 , pp. 237-248
    • Holt, S.E.1    Norton, J.C.2    Wright, W.E.3    Shay, J.W.4
  • 56
    • 1842414238 scopus 로고    scopus 로고
    • Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay
    • Krupp G., Kuhne K., Tamm S., Klapper W., Heidron K., Rott A., Parwaresch R. Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay. Nucleic Acids Res. 25:1997;919-921.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 919-921
    • Krupp, G.1    Kuhne, K.2    Tamm, S.3    Klapper, W.4    Heidron, K.5    Rott, A.6    Parwaresch, R.7
  • 57
    • 0032004602 scopus 로고    scopus 로고
    • Increase sensitivity and reproducibility of TRAP assay by avoiding primers interaction
    • Falchetti M.L., Levi A., Molinari P., Verma R., D'Ambrosio Increase sensitivity and reproducibility of TRAP assay by avoiding primers interaction. Nucleic Acids Res. 26:1998;862-863.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 862-863
    • Falchetti, M.L.1    Levi, A.2    Molinari, P.3    Verma, R.4    D'Ambrosio5
  • 58
    • 0030743347 scopus 로고    scopus 로고
    • Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP)
    • Kim N.W., Wu F. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25:1997;2595-2597.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2595-2597
    • Kim, N.W.1    Wu, F.2
  • 59
    • 0033009346 scopus 로고    scopus 로고
    • Detection of telomerase activity utilizing energy transfer primers: Comparison with gel-and ELISA-based detection
    • Uehara H., Nardone G., nazarenko I., Hohman R.J. Detection of telomerase activity utilizing energy transfer primers: comparison with gel-and ELISA-based detection. BioTechniques. 26:1999;552-558.
    • (1999) BioTechniques , vol.26 , pp. 552-558
    • Uehara, H.1    Nardone, G.2    Nazarenko, I.3    Hohman, R.J.4
  • 61
    • 0029023065 scopus 로고
    • Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity
    • Wright W.E., Shay J.W., Piatyszek M.A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res. 23:1995;3794-3795.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 3794-3795
    • Wright, W.E.1    Shay, J.W.2    Piatyszek, M.A.3
  • 62
    • 0034739717 scopus 로고    scopus 로고
    • Alternative methods of extracting telomerase activity from human tumor samples
    • Gollahon L.S., Holt S.E. Alternative methods of extracting telomerase activity from human tumor samples. Cancer Lett. 159:2000;141-149.
    • (2000) Cancer Lett. , vol.159 , pp. 141-149
    • Gollahon, L.S.1    Holt, S.E.2
  • 63
    • 0034659882 scopus 로고    scopus 로고
    • Modified telomeric repeat amplification protocol: A quantitative radioactive assay for telomerase without using electrophoresis
    • Szatmari I., Tokes S., Dunn C.B., Bardos T.J., Aradi J. Modified telomeric repeat amplification protocol: a quantitative radioactive assay for telomerase without using electrophoresis. Anal. Biochem. 282:2000;80-88.
    • (2000) Anal. Biochem. , vol.282 , pp. 80-88
    • Szatmari, I.1    Tokes, S.2    Dunn, C.B.3    Bardos, T.J.4    Aradi, J.5
  • 64
    • 0035864173 scopus 로고    scopus 로고
    • Telomeric repeat amplification, without shortening or lengthening of the telomerase products: A method to analyze the processivity of telomerase enzyme
    • Szatmari I., Aradi J. Telomeric repeat amplification, without shortening or lengthening of the telomerase products: a method to analyze the processivity of telomerase enzyme. Nucleic Acids Res. 29:2001;1-4.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 1-4
    • Szatmari, I.1    Aradi, J.2
  • 65
    • 0024969084 scopus 로고
    • Scintillation proximity assay
    • Bosworth N., Towers P. Scintillation proximity assay. Nature. 341:1989;167-168.
    • (1989) Nature , vol.341 , pp. 167-168
    • Bosworth, N.1    Towers, P.2
  • 66
    • 0029935711 scopus 로고    scopus 로고
    • Detection of telomerase activity by combination of TRAP method and scintillation proximity assay (SPA)
    • Savoysky E., Akamatsu K-i., Tsuchiya M., Yamazaki T. Detection of telomerase activity by combination of TRAP method and scintillation proximity assay (SPA). Nucleic Acids Res. 24:1996;1175-1176.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 1175-1176
    • Savoysky, E.1    Akamatsu, K.-I.2    Tsuchiya, M.3    Yamazaki, T.4
  • 67
    • 0035104256 scopus 로고    scopus 로고
    • Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity
    • Hou M., Xu D., Bjorkholm M., Gruber A. Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity. Clin. Chem. 47:2001;519-524.
    • (2001) Clin. Chem. , vol.47 , pp. 519-524
    • Hou, M.1    Xu, D.2    Bjorkholm, M.3    Gruber, A.4
  • 68
    • 0035139390 scopus 로고    scopus 로고
    • Telomerase activity in prostate sextant needle cores from radiation prostatectomy specimens
    • Wang Z., Ramin S.A., Tsai C., Lui P., Ruckle H.C., Beltz R.E., Sands J.F. Telomerase activity in prostate sextant needle cores from radiation prostatectomy specimens. Urol. Oncol. 6:2001;57-62.
    • (2001) Urol. Oncol. , vol.6 , pp. 57-62
    • Wang, Z.1    Ramin, S.A.2    Tsai, C.3    Lui, P.4    Ruckle, H.C.5    Beltz, R.E.6    Sands, J.F.7
  • 73
    • 0034533914 scopus 로고    scopus 로고
    • Diagnosis of bladder cancer using telomerase activity in voided urine
    • Cheng C.W., Chueh S.C., Chern H.D. Diagnosis of bladder cancer using telomerase activity in voided urine. J. Formos. Med. Assoc. 99:2000;920-925.
    • (2000) J. Formos. Med. Assoc. , vol.99 , pp. 920-925
    • Cheng, C.W.1    Chueh, S.C.2    Chern, H.D.3
  • 76
    • 0024412288 scopus 로고
    • Assay formats involving acridium-ester labeled DNA probes
    • Arnold l.J., Hammond P.W., Wiese W.A., Nelson N.C. Assay formats involving acridium-ester labeled DNA probes. Clin. Chem. 35:1989;1588-1594.
    • (1989) Clin. Chem. , vol.35 , pp. 1588-1594
    • Arnold, I.J.1    Hammond, P.W.2    Wiese, W.A.3    Nelson, N.C.4
  • 77
    • 0025975208 scopus 로고
    • Hybridization protection assay: A rapid, sensitive, and specific method for detection of philadelphia chromosome-positive leukemias
    • Dhingra K., Talpaz M., Riggs M., Eastman P.S., Zipf T., Ku S., Kurzrock R. Hybridization protection assay: a rapid, sensitive, and specific method for detection of philadelphia chromosome-positive leukemias. Blood. 77:1991;238-242.
    • (1991) Blood , vol.77 , pp. 238-242
    • Dhingra, K.1    Talpaz, M.2    Riggs, M.3    Eastman, P.S.4    Zipf, T.5    Ku, S.6    Kurzrock, R.7
  • 78
    • 0031672718 scopus 로고    scopus 로고
    • New method to measure telomerase activity by transcription-mediated amplification and hybridizatrion protection assay
    • Hirose M., Hashimoto J.A., Tahara H., Ide T., Yoshimura T. New method to measure telomerase activity by transcription-mediated amplification and hybridizatrion protection assay. Clin. Chem. 44:1998;2446-2452.
    • (1998) Clin. Chem. , vol.44 , pp. 2446-2452
    • Hirose, M.1    Hashimoto, J.A.2    Tahara, H.3    Ide, T.4    Yoshimura, T.5
  • 79
    • 0032186160 scopus 로고    scopus 로고
    • Quantitative polymerase chain reaction based on a dual-analyte chemiluminescence hybridization assay for target DNA and internal standard
    • Verhaegen M., Christopoulos T.K. Quantitative polymerase chain reaction based on a dual-analyte chemiluminescence hybridization assay for target DNA and internal standard. Anal. Chem. 70:1998;4120-4125.
    • (1998) Anal. Chem. , vol.70 , pp. 4120-4125
    • Verhaegen, M.1    Christopoulos, T.K.2
  • 80
    • 0034964554 scopus 로고    scopus 로고
    • Development of a quantitative luminometric hybridization assay for the determination of telomerase activity
    • Kolioliou M., Talieri M., Lianidou E.S. Development of a quantitative luminometric hybridization assay for the determination of telomerase activity. Clin. Biochem. 34:2001;277-284.
    • (2001) Clin. Biochem. , vol.34 , pp. 277-284
    • Kolioliou, M.1    Talieri, M.2    Lianidou, E.S.3
  • 81
    • 0032189237 scopus 로고    scopus 로고
    • A homogenous chemiluminescent assay for telomerase
    • Lackely D.B. A homogenous chemiluminescent assay for telomerase. Anal. Biochem. 263:1998;57-61.
    • (1998) Anal. Biochem. , vol.263 , pp. 57-61
    • Lackely, D.B.1
  • 82
  • 85
    • 0033547413 scopus 로고    scopus 로고
    • Enzymatic activity of endogenous telomerase associated with intact nuclei from human leukemia CEM cells
    • Fletcher T.M., Trevino A., Woynarowski J.M. Enzymatic activity of endogenous telomerase associated with intact nuclei from human leukemia CEM cells. Biochem. Biophys. Res. Commun. 265:1999;51-56.
    • (1999) Biochem. Biophys. Res. Commun. , vol.265 , pp. 51-56
    • Fletcher, T.M.1    Trevino, A.2    Woynarowski, J.M.3
  • 87
    • 0031715328 scopus 로고    scopus 로고
    • Tissue quality is an important determinant of telomerase activity as measured by TRAP
    • Yan P., Bosman F.T., Benhattar Tissue quality is an important determinant of telomerase activity as measured by TRAP. BioTechniques. 25:1998;660-662.
    • (1998) BioTechniques , vol.25 , pp. 660-662
    • Yan, P.1    Bosman, F.T.2    Benhattar3
  • 88
    • 0032803237 scopus 로고    scopus 로고
    • Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
    • Tesmer V.M., Ford L.P., Holt S.E., Frank B.C., Yi X., Aisner D.L., Quellette M., Shay J.W., Wright W.E. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19:1999;6207-6216.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6207-6216
    • Tesmer, V.M.1    Ford, L.P.2    Holt, S.E.3    Frank, B.C.4    Yi, X.5    Aisner, D.L.6    Quellette, M.7    Shay, J.W.8    Wright, W.E.9
  • 90
    • 0034520826 scopus 로고    scopus 로고
    • Detection of hTERT protein by flow cytometry
    • Ali A.S.M., Chopra R., Robertson J., Testa N.G. Detection of hTERT protein by flow cytometry. Leukemia. 14:2000;2176-2181.
    • (2000) Leukemia , vol.14 , pp. 2176-2181
    • Ali, A.S.M.1    Chopra, R.2    Robertson, J.3    Testa, N.G.4
  • 91
    • 0035154623 scopus 로고    scopus 로고
    • PCR and in situ hybridization studies of telomerase subunits in human non-neoplastic livers
    • Harada K., Yasoshima M., Ozaki S., Sanzen T., Nakanuma Y. PCR and in situ hybridization studies of telomerase subunits in human non-neoplastic livers. J. Pathol. 193:2001;210-217.
    • (2001) J. Pathol. , vol.193 , pp. 210-217
    • Harada, K.1    Yasoshima, M.2    Ozaki, S.3    Sanzen, T.4    Nakanuma, Y.5
  • 94
  • 95
    • 0031703757 scopus 로고    scopus 로고
    • Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer
    • Nakano K., Watney E., McDougall J.K. Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer. Am. J. Pathol. 153:1998;857-864.
    • (1998) Am. J. Pathol. , vol.153 , pp. 857-864
    • Nakano, K.1    Watney, E.2    McDougall, J.K.3
  • 96
    • 0035945966 scopus 로고    scopus 로고
    • Expression of the RNA component of human telomerase (hTR) in thin prep preparations from bladder washings
    • Maitra A., Rathi A., Gazdar A.F., Sagalowsky A., Ashfaq R. Expression of the RNA component of human telomerase (hTR) in thin prep preparations from bladder washings. Cancer. 93:2001;73-79.
    • (2001) Cancer , vol.93 , pp. 73-79
    • Maitra, A.1    Rathi, A.2    Gazdar, A.F.3    Sagalowsky, A.4    Ashfaq, R.5
  • 97
    • 0027982292 scopus 로고
    • Detection of growth hormone-producing cells in human thymus by immunohistocytochemistry and non-radiactive in situ hybridization
    • Maggiano N., Piantelli M., Ricci R., Larocca L.M., Capelli A., Ranelletti F.O. Detection of growth hormone-producing cells in human thymus by immunohistocytochemistry and non-radiactive in situ hybridization. J. Histochem. Cytochem. 42:1994;1349-1354.
    • (1994) J. Histochem. Cytochem. , vol.42 , pp. 1349-1354
    • Maggiano, N.1    Piantelli, M.2    Ricci, R.3    Larocca, L.M.4    Capelli, A.5    Ranelletti, F.O.6
  • 98
    • 0033198499 scopus 로고    scopus 로고
    • High telomerase reverse transcriptase (hTERT) messenger RNA levels correlates with tumor recurrence in patients with favorable histology Wilms' tumor
    • Dome J.S., Chung S., Bergemann T., Umbritch C.B., Saji M., Carey L.A., Grundy P.E., Periman E.J., Breslow N.E., Sukumar S. High telomerase reverse transcriptase (hTERT) messenger RNA levels correlates with tumor recurrence in patients with favorable histology Wilms' tumor. Cancer Res. 59:1999;4301-4307.
    • (1999) Cancer Res. , vol.59 , pp. 4301-4307
    • Dome, J.S.1    Chung, S.2    Bergemann, T.3    Umbritch, C.B.4    Saji, M.5    Carey, L.A.6    Grundy, P.E.7    Periman, E.J.8    Breslow, N.E.9    Sukumar, S.10
  • 100
    • 0343415646 scopus 로고    scopus 로고
    • Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay
    • Bieche I., Nogues C., Paradis V., Olivi M., Bedossa P., Lidereau, Viduad M. Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay. Clin. Cancer Res. 6:2000;452-459.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 452-459
    • Bieche, I.1    Nogues, C.2    Paradis, V.3    Olivi, M.4    Bedossa, P.5    Lidereau6    Viduad, M.7
  • 101
    • 12244268341 scopus 로고    scopus 로고
    • Detection of telomerase components by quantitative real-time-on-line PCR analysis with the LightCycler
    • Emrich T., Karl G., Panzinger B. Detection of telomerase components by quantitative real-time-on-line PCR analysis with the LightCycler. Biochemica. 4:2000;16-19.
    • (2000) Biochemica , vol.4 , pp. 16-19
    • Emrich, T.1    Karl, G.2    Panzinger, B.3
  • 102
    • 12244296818 scopus 로고    scopus 로고
    • The LightCycler instrument and MagNA pure LC: An automated system for the evaluation of telomerase expression by quantitative RT-PCR
    • Emrich T., Karl G., Panzinger B. The LightCycler instrument and MagNA pure LC: an automated system for the evaluation of telomerase expression by quantitative RT-PCR. Biochemica. 4:2000;10-13.
    • (2000) Biochemica , vol.4 , pp. 10-13
    • Emrich, T.1    Karl, G.2    Panzinger, B.3
  • 103
    • 0035253472 scopus 로고    scopus 로고
    • Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion
    • Sato N., Maehara N., Mizumoto K., Nagai E., Yasoshima T., Hirata K., Tanaka M. Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion. Cancer. 91:2001;496-504.
    • (2001) Cancer , vol.91 , pp. 496-504
    • Sato, N.1    Maehara, N.2    Mizumoto, K.3    Nagai, E.4    Yasoshima, T.5    Hirata, K.6    Tanaka, M.7
  • 105
    • 0035270901 scopus 로고    scopus 로고
    • Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy
    • Kobayashi T., Kubota K., Takayama T., Makuuchi M. Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy. Am. J. Surg. 181:2001;284-288.
    • (2001) Am. J. Surg. , vol.181 , pp. 284-288
    • Kobayashi, T.1    Kubota, K.2    Takayama, T.3    Makuuchi, M.4
  • 106
    • 0012625945 scopus 로고    scopus 로고
    • Prognostic significance of telomerase in brain tumors
    • Gross R., Schiffer D. Prognostic significance of telomerase in brain tumors. Crit. Rev. Neurosurg. 8:1998;244-247.
    • (1998) Crit. Rev. Neurosurg. , vol.8 , pp. 244-247
    • Gross, R.1    Schiffer, D.2
  • 107
    • 0035283896 scopus 로고    scopus 로고
    • Tissue- specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development
    • Ulaner G.A., Hu J.F., Vu T.H., Giudice L.C., Hoffman A.R. Tissue- specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int. J. Cancer. 91:2001;644-649.
    • (2001) Int. J. Cancer , vol.91 , pp. 644-649
    • Ulaner, G.A.1    Hu, J.F.2    Vu, T.H.3    Giudice, L.C.4    Hoffman, A.R.5
  • 108
    • 0034523665 scopus 로고    scopus 로고
    • An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
    • Yi X., White D.M., Aisner D.L., Baur J.A., Wright W.E., Shay J.W. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia. 2:2000;433-440.
    • (2000) Neoplasia , vol.2 , pp. 433-440
    • Yi, X.1    White, D.M.2    Aisner, D.L.3    Baur, J.A.4    Wright, W.E.5    Shay, J.W.6
  • 109
    • 0032530136 scopus 로고    scopus 로고
    • Telomerase activity in human development is regulated by human telomerase reverse transcritpase (hTERT) transcription and by alternate splicing of hTERT transcripts
    • Ulaner G.A., Hu J.F., Vu T.H., Giudice L.C., Hoffman A.R. Telomerase activity in human development is regulated by human telomerase reverse transcritpase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58:1998;4168-4172.
    • (1998) Cancer Res. , vol.58 , pp. 4168-4172
    • Ulaner, G.A.1    Hu, J.F.2    Vu, T.H.3    Giudice, L.C.4    Hoffman, A.R.5


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