Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats

Journal of Neurosurgery

Volumn 98, Issue 4, 2003, Pages 867-873

  Dempsey, Robert J ^a   Raghavendra Rao, Vemuganti L ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Controlled cortical impact; Cytidinediphosphocholine; Hippocampus; Neuroprotection; Phospholipase; Rat; Secondary neuronal death

Indexed keywords

ALTEPLASE; BASIC FIBROBLAST GROWTH FACTOR; CALPAIN; CITICOLINE; DEXANABINOL; DEXTRORPHAN; DIZOCILPINE; IFENPRODIL; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENCYCLIDINE; PHOSPHOLIPASE A2; PHOSPHOLIPID; REMACEMIDE; SODIUM CHLORIDE; UROKINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CONTUSION; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; CRANIECTOMY; HIPPOCAMPUS; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NERVE CELL NECROSIS; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

EID: 0037380205     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2003.98.4.0867     Document Type: Article

References (45)

1. Adibhatla RM, Hatcher JF, Dempsey RJ: Citicoline: neuroprotective mechanisms in cerebral ischemia. J Neurochem 80:12-23, 2002
2. Alkan T, Kahveci N, Goren B, et al: Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of cificoline. Arch Physiol Biochem 109:161-167, 2001
3. Andersen M, Overgaard K, Meden P, et al: Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model. Stroke 30:1464-1471, 1999
4. Baskaya MK, Dogan A, Rao AM, et al: Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg 92:448-452, 2000
5. Baskaya MK, Dogan A, Temiz C, et al: Application of 2,3,5-triphenyltetrazolium chloride staining to evaluate injury volume after controlled cortical impact brain injury: role of brain edema in evolution of injury volume. J Neurotrauma 17:93-99, 2000
6. Bonventre JV: Roles of phospholipases A2 in brain cells and tissue injury associated with ischemia and excitotoxicity. J Lipid Mediat Cell Signal 16:199-208, 1997
7. 2. Nature 390:622-625, 1997
8. Chabrier PE, Auguet M, Spinnewyn B, et al: BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy. Proc Natl Acad Sci USA 96:10824-10829, 1999
9. Clark W, Gunion-Rinker L, Lessov N, et al: Citicoline treatment for experimental intracerebral hemorrhage in mice. Stroke 29:2136-2140, 1998
10. Dempsey RJ, BaskayaMK, Dogan A: Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery 47:399-406, 2000
11. Dhillon HS, Donaldson D, Dempsey RJ, et al: Regional levels of free fatty acids and Evans blue extravasation after experimental brain injury. J Neurotrauma 11:405-415, 1994
12. Dixon CE, Kochanek PM, Yan HQ, et al: One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats. J Neurotrauma 16:109-122, 1999
13. Dixon CE, Ma X, Marion DW: Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal neocortical acetylcholine release. J Neurotrauma 14:161-169, 1997
14. Dogan A, Rao AM, Baskaya MK, et al: Contribution of polyamine oxidase to brain injury after trauma. J Neurosurg 90:1078-1082, 1999
15. Doppenberg EM, Bullock R: Clinical neuro-protection trials in severe traumatic brain injury: lessons from previous studies. J Neurotrauma 14:71-80, 1997
16. Faden AI: Comparison of single and combination drug treatment strategies in experimental brain trauma. J Neurotrauma 10:91-100, 1993
17. Goodman JC, Cherian L, Bryan RM Jr, et al: Lateral cortical impact injury in rats: pathologic effects of varying cortical compression and impact velocity. J Neurotrauma 11:587-597, 1994
18. Kennedy EP, Weiss SB: The function of cytidine coenzymes in the biosynthesis of phospholipids. J Biol Chem 222:193-214, 1956
19. Kim BT, Rao VL, Sailor KA, et al: Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats. J Neurosurg 95:674-679, 2001
20. Kornhuber J, Weller M: Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry 41:135-144, 1997
21. Kumar A, Zou L, Yuan X, et al: N-methyl-D-aspartate receptors: transient loss of NR1/NR2A/NR2B subunits after traumatic brain injury in a rodent model. J Neurosci Res 67:781-786, 2002
22. McIntosh TK, Juhler M, Wieloch T: Novel pharmacological strategies in the treatment of experimental traumatic brain injury. J Neurotrauma 15:731-769, 1998
23. McIntosh TK, Vink R, Noble L, et al: Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28:233-244, 1989
24. Miller LP, Lyeth BG, Jenkins LW, et al: Excitatory amino acid receptor subtype binding following traumatic brain injury. Brain Res 526:103-107, 1990
25. Mukhin A, Fan L, Faden AI: Activation of metabotropic glutamate receptor subtype mGluR 1 contributes to post-traumatic neuronal injury. J Neurosci 16:6012-6020, 1996
26. Nilsson P, Hillered L, Ponten U, et al: Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J Cereb Blood Flow Metab 10:631-637, 1990
27. Onal MZ, Li F, Tatlisumak T, et al: Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke 28:1060-1065, 1997
28. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, ed 4. New York: Academic Press, 1998
29. Raghavendra Rao VL, Dogan A, Bowen KK, et al: Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol 161:102-114, 2000
30. Rao AM, Hatcher JF, Dempsey RJ: CDP-choline: neuroprotection in transient forebrain ischemia of gerbils J. Neurosci Res 58:697-705, 1999
31. Rao AM, Hatcher JF, Dempsey RJ: Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. Stroke 32:2376-2381, 2001
32. Rao VLR, Baskaya MK, Dogan A, et al: Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain. J Neurochem 70:2020-2027, 1998
33. Rao VLR, Dogan A, Bowen KK, et al: Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain. Eur J Neurosci 13:119-128, 2001
34. 3H]nitroarginine binding. J Neurotrauma 16:865-877, 1999
35. Rao VLR, Dogan A, Todd KG, et al: Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats. Brain Res 911:96-100, 2001
36. Saatmma KE, Murai H, Bartus RT, et al: Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat. Proc Natl Acad Sci USA 93:3428-3433, 1996
37. Schabitz WR, Li F, Katsumi I, et al: Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke 30:427-432, 1999
38. Schabitz WR, Weber J, Takano K, et al: The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J Neurol Sci 138:21-25, 1996
39. Scheff SW, Baldwin SA, Brown RW, et al: Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J Neurotrauma 14:615-627, 1997
40. Shuaib A, Yang Y, Li Q: Evaluating the efficacy of citicoline in embolic ischemic stroke in rats: neuroprotective effects when used alone or in combination with urokinase. Exp Neurol 161:733-739, 2000
41. Sihver S, Marklund N, Hillered L, et al: Changes in mACh, NMDA and GABA(A) receptor binding after lateral fluid-percussion injury: in vitro autoradiography of rat brain frozen sections. J Neurochem 78:417-423, 2001
42. Stoffel M, Rinecker M, Plesnila N, et al: Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury. J Neurotrauma 18:425-434, 2001
43. Sun FY, Faden AI: Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats. Brain Res 693:163-168, 1995
44. Weber JT, Rzigalinski BA, Ellis EF: Traumatic injury of cortical neurons causes changes in the intracellular calcium stores and capacitative calcium influx. J Biol Chem 276:1800-1807, 2001
45. Yakovlev AG, Knoblach SM, Fan L, et al: Activation of CPP-32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 17:7415-7424, 1997