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Using chromatin immunoprecipitation experiments it was demonstrated here that histone H4 acetylation on dosage compensated genes correlates with coding regions rather than the promoter regions on the X chromosome, implying that the DCC may function to promote transcription elongation.
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Even though roX RNAs seem to have redundant function, it is convincingly shown here that deletion of roX1 and roX2 genes in flies causes male-specific lethality and mistargeting of the MSL proteins as well as histone H4 lysine 16 acetylation.
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We here characterised MOF substrate specificity and showed that the MOF zinc finger region is important for interaction with histone H4 tail on a nucleosomal substrate.
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Dosage-dependent gene regulation in multicellular eukaryotes: Implications for dosage compensation, aneuploid syndromes, and quantitative traits
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Birchler J.A., Bhadra U., Bhadra M.P., Auger D.L. Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits. Dev. Biol. 234:2001;275-288.
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(2001)
Dev. Biol.
, vol.234
, pp. 275-288
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Birchler, J.A.1
Bhadra, U.2
Bhadra, M.P.3
Auger, D.L.4
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44
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0033166349
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JIL1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila
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Jin Y., Wang Y., Walker D.L., Dong H., Conley C., Johansen J., Johansen K.M. JIL1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol. Cell. 4:1999;129-135.
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(1999)
Mol. Cell.
, vol.4
, pp. 129-135
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Jin, Y.1
Wang, Y.2
Walker, D.L.3
Dong, H.4
Conley, C.5
Johansen, J.6
Johansen, K.M.7
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45
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0035906859
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The Jil-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila
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Here, hypomorphic mutant alleles of JIL-1 the histone H3 kinase were created to show that JIL-1 is required for global chromatin structure. The X chromosome was show to be severely affected. However, despite the altered appearance the dosage compensation members were still found on the male X chromosome.
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Wang Y., Zhang W., Jin Y., Johansen J., Johansen K.M. The Jil-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell. 105:2001;433-443 Here, hypomorphic mutant alleles of JIL-1 the histone H3 kinase were created to show that JIL-1 is required for global chromatin structure. The X chromosome was show to be severely affected. However, despite the altered appearance the dosage compensation members were still found on the male X chromosome.
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(2001)
Cell
, vol.105
, pp. 433-443
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Wang, Y.1
Zhang, W.2
Jin, Y.3
Johansen, J.4
Johansen, K.M.5
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46
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0035943606
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Recruitment of the male-specific lethal (MSL) dosage compensation complex to an autosomally integrated roX chromatin entry site correlates with an increased expression of an adjacent reporter gene in male Drosophila
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••] was not sufficient for twofold transcription increase, suggesting that additional sequences may be required for transcription regulation.
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••] was not sufficient for twofold transcription increase, suggesting that additional sequences may be required for transcription regulation.
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(2001)
J. Biol. Chem.
, vol.276
, pp. 31953-31958
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Henry, R.A.1
Tews, B.2
Li, X.3
Scott, M.J.4
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47
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0036479009
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Chromosomal silencing and localisation are mediated by different domains of Xist RNA
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In this study, the authors made a series of deletions of Xist RNA and by using an elegant inducible ES cell expression system showed that different functional domains can be identified in Xist RNA. A silencing feature within Xist seems to reside within a conserved repeat sequence at the 5′ end of the RNA.
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Wutz A., Rasmussen T.P., Jaenisch R. Chromosomal silencing and localisation are mediated by different domains of Xist RNA. Nat. Genet. 30:2002;1-8 In this study, the authors made a series of deletions of Xist RNA and by using an elegant inducible ES cell expression system showed that different functional domains can be identified in Xist RNA. A silencing feature within Xist seems to reside within a conserved repeat sequence at the 5′ end of the RNA.
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(2002)
Nat. Genet.
, vol.30
, pp. 1-8
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Wutz, A.1
Rasmussen, T.P.2
Jaenisch, R.3
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48
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0036532224
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X-chromosome inactivation and the search for chromosome-wide silencers
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Cohen D.E., Lee J.T. X-chromosome inactivation and the search for chromosome-wide silencers. Curr. Opin. Genet. Dev. 12:2002;219-224.
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(2002)
Curr. Opin. Genet. Dev.
, vol.12
, pp. 219-224
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Cohen, D.E.1
Lee, J.T.2
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49
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0035228079
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X-chromosome inactivation: Counting, choice and initiation
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Avner P., Heard E. X-chromosome inactivation: counting, choice and initiation. Nat. Rev. Genet. 2:2001;59-67.
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(2001)
Nat. Rev. Genet.
, vol.2
, pp. 59-67
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Avner, P.1
Heard, E.2
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50
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0036641071
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X-chromosome inactivation: Closing in on proteins that bind Xist RNA
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Brockdorff N. X-chromosome inactivation: closing in on proteins that bind Xist RNA. Trends Genet. 18:2002;352-358.
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(2002)
Trends Genet.
, vol.18
, pp. 352-358
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Brockdorff, N.1
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53
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0037166937
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Cell cycle-dependent localisation of macro H2A in chromatin of the inactive X chromosome
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Chadwick B.P., Willard H.F. Cell cycle-dependent localisation of macro H2A in chromatin of the inactive X chromosome. J. Cell. Biol. 157:2002;1113-1123.
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(2002)
J. Cell. Biol.
, vol.157
, pp. 1113-1123
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Chadwick, B.P.1
Willard, H.F.2
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54
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18744372123
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BRCA1 supports XIST RNA concentration on the inactive X chromosome
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An interesting new connection between the well-studied BRCA1 gene and X inactivation is made in this paper. Using a combination of knockout cell lines as well as RNA interference, BRCA1 is shown to play an important role in Xist RNA localisation, therefore leading to new insights into X inactivation.
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Ganesan S., Silver D.P., Greenberg R.A., Avni D., Drapkin R., Miron A., Mok S.C., Randrianarison V., Brodie S., Salstrom S.et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 111:2002;393-405 An interesting new connection between the well-studied BRCA1 gene and X inactivation is made in this paper. Using a combination of knockout cell lines as well as RNA interference, BRCA1 is shown to play an important role in Xist RNA localisation, therefore leading to new insights into X inactivation.
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(2002)
Cell
, vol.111
, pp. 393-405
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Ganesan, S.1
Silver, D.P.2
Greenberg, R.A.3
Avni, D.4
Drapkin, R.5
Miron, A.6
Mok, S.C.7
Randrianarison, V.8
Brodie, S.9
Salstrom, S.10
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55
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0033973262
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A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF
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Neal K.C., Pannuti A., Smith E.R., Lucchesi J.C. A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF. Biochim. Biophys. Acta. 1490:2000;170-174.
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(2000)
Biochim. Biophys. Acta
, vol.1490
, pp. 170-174
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Neal, K.C.1
Pannuti, A.2
Smith, E.R.3
Lucchesi, J.C.4
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56
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0033868471
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Origin and evolution of the regulatory gene male-specific lethal-3
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Marin I., Baker B.S. Origin and evolution of the regulatory gene male-specific lethal-3. Mol. Biol. Evol. 17:2000;1240-1250.
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(2000)
Mol. Biol. Evol.
, vol.17
, pp. 1240-1250
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Marin, I.1
Baker, B.S.2
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57
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0034602829
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MSL1 plays a central role in assembly of the MSL complex, essential for dosage compensation in Drosophila
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Scott M.J., Pan L.L., Cleland S.B., Knox A.L., Heinrich J. MSL1 plays a central role in assembly of the MSL complex, essential for dosage compensation in Drosophila. EMBO J. 19:2000;144-155.
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(2000)
EMBO J.
, vol.19
, pp. 144-155
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Scott, M.J.1
Pan, L.L.2
Cleland, S.B.3
Knox, A.L.4
Heinrich, J.5
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58
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0027232086
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The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males
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Palmer M.J., Mergner V.A., Richman R., Manning J.E., Kuroda M.I., Lucchesi J.C. The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males. Genetics. 134:1993;545-557.
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(1993)
Genetics
, vol.134
, pp. 545-557
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Palmer, M.J.1
Mergner, V.A.2
Richman, R.3
Manning, J.E.4
Kuroda, M.I.5
Lucchesi, J.C.6
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59
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0033988212
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The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation
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Smith E.R., Pannuti A., Gu W., Steurnagel A., Cook R.G., Allis C.D., Lucchesi J.C. The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol. Cell. Biol. 20:2000;312-318.
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(2000)
Mol. Cell. Biol.
, vol.20
, pp. 312-318
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Smith, E.R.1
Pannuti, A.2
Gu, W.3
Steurnagel, A.4
Cook, R.G.5
Allis, C.D.6
Lucchesi, J.C.7
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