Functional analysis of gap junctions in ovarian granulosa cells: Distinct role for connexin43 in early stages of folliculogenesis

American Journal of Physiology - Cell Physiology

Volumn 284, Issue 4 53-4, 2003, Pages

  Gittens, Joanne E I ^a,b   Mhawi, Abdul Amir ^a,b   Lidington, Darcy ^a,b   Ouellette, Yves ^a,b   Kidder, Gerald M ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b CHILDREN S HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

Hemichannels; Intercellular communication; 1 connexin

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL CONTACT; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GAP JUNCTION; GRANULOSA CELL; ION CURRENT; MOUSE; NONHUMAN; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA;

EID: 0037376189     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00277.2002     Document Type: Article

References (38)

1. Ackert CL, Gittens JEI, O'Brien MJ, Eppig JJ, and Kidder GM. Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse. Dev Biol 233: 258-270, 2001.
2. Alcoléa S, Théveniau-Ruissy M, Jarry-Guichard T, Marics I, Tzouanacou E, Chauvin JP, Briand JP, Moorman AFM, Lamers WH, and Gros D. Downregulation of connexin45 gene products during mouse heart development. Circ Res 84: 1365-1379, 1999.
3. + fluxes in intact cells. FASEB J 15: 10-12, 2001.
4. Bukauskas FF, Elfgang C, Willecke K, and Weingart R. Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human cells. Biophys J 68: 2289-2298, 1995.
5. Carabatsos MJ, Sellitto C, Goodenough DA, and Albertini DF. Oocyte-granulosa cell heterologous gap junctions are required for the coordination of nuclear and cytoplasmic meiotic competence. Dev Biol 226: 167-179, 2000.
6. Castro C, Gómez-Hernandez JM, Silander K, and Barrio LC. Altered formation of hemichannels and gap junction channels caused by C-terminal connexin-32 mutations. J Neurosci 19: 3752-3760, 1999.
7. Contreras JE, Sánchez HA, Eugenin EA, Speidel D, Theis M, Willecke K, Bukauskas FF, Bennett MVL, and Sáez JC. Metabolic inhibition induces opening of unopposed connexin43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc Natl Acad Sci USA 99: 495-500, 2002.
8. Eloff BC, Lerner DL, Yamada KA, Schuessler RB, Saffitz JE, and Rosenbaum DS. High resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc Res 51: 681-690, 2001.
9. Eskandari S, Zampighi GA, Leung DW, Wright EM, and Loo DDF. Inhibition of gap junction hemichannels by chloride channel blockers. J Membr Biol 185: 93-102, 2002.
10. i. Dev Genet 24: 123-136, 1999.
11. Fujiwara T, Oda K, Yokota S, Takatsuki A, and Ikehara Y. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J Biol Chem 263: 18545-18552, 1988.
12. Gao Y and Spray DC. Structural changes in lenses of mice lacking the gap junction protein connexin43. Invest Ophthalmol Vis Sci 39: 1198-1209, 1998.
13. Goldberg GS, Bechberger JF, and Naus CCG. A pre-loading method of evaluating gap junctional communication by fluorescent dye transfer. Biotechniques 18: 490-497, 1995.
14. Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, and Saffitz JE. Slow ventricular contraction in mice heterozygous for a connexin43 null mutation. J Clin Invest 99: 1991-1998, 1997.
15. Itahana K, Tanaka T, Morikazu Y, Komatu S, Ishida N, and Takeya T. Isolation and characterization of a novel connexin gene, Cx-60, in porcine ovarian follicles. Endocrinology 139: 320-329, 1998.
16. John SA, Kondo R, Wang SY, Goldhaber JI, and Weiss JN. Connexin43 hemichannels opened by metabolic inhibition. J Biol Chem 274: 236-240, 1999.
17. Juneja SC, Barr KJ, Enders GC, and Kidder GM. Defects in the germ line and gonads of mice lacking connexin43. Biol Reprod 60: 1263-1270, 1999.
18. Kamermans M, Fahrenfort I, Schultz K, Janssen-Bienhold U, Sjoerdsma T, and Weiler R. Hemichannel-mediated inhibition in the outer retina. Science 292: 1178-1180, 2001.
19. Kidder GM and Mhawi AA. Gap junctions and ovarian folliculogenesis. Reproduction 123: 613-620, 2002.
20. Lauf U, Giepmans BNG, Lopez P, Braconnot S, Chen SC, and Falk MM. Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells. Proc Natl Acad Sci USA 99: 10446-10451, 2002.
21. Lecanda F, Warlow PM, Sheikh S, Furlan F, Steinberg TH, and Civitelli R. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151: 931-943, 2000.
22. Lerner DL, Yamada KA, Schuessler RB, and Saffitz JE. Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Circulation 101: 547-552, 2000.
23. Li H, Liu TF, Lazrak A, Peracchia C, Goldberg GS, Lampe PD, and Johnson RG. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 134: 1019-1030, 1996.
24. Li R and Mather JP. Lindane, an inhibitor of gap junction formation, abolishes oocyte directed follicle organizing activity in vitro. Endocrinology 138: 4477-4480, 1997.
25. Manthey D, Bukauskas F, Lee CG, Kozak CA, and Willecke K. Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells. J Biol Chem 274: 14716-14723, 1999.
26. Mao AJ, Bechberger J, Lidington D, Galipeau J, Laird DW, and Naus CCG. Neuronal differentiation and growth control of neuro-2a cells after retroviral gene delivery of connexin43. J Biol Chem 275: 34407-34414, 2000.
27. Montecino-Rodriguez E and Dorshkind K. Regulation of hematopoiesis by gap junction-mediated intercellular communication. J Leukoc Biol 70: 341-347, 2001.
28. Okuma A, Kuraoka A, Iida H, Inai T, Wasano K, and Shibata Y. Colocalization of connexin 43 and connexin 45 but absence of connexin 40 in granulosa cell gap junctions of rat ovary. J Reprod Fertil 107: 255-264, 1996.
29. Plotkin LI, Manolagas SC, and Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem 277: 8648-8657, 2002.
30. Quist AP, Rhee SK, Lin H, and Lal R. Physiological role of gap-junctional hemichannels: extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 148: 1063-1074, 2000.
31. Reaume AG, De Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, and Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 267: 1831-1834 1995.
32. Roscoe WA, Barr KJ, Mhawi AA, Pomerantz DK, and Kidder GM. Failure of spermatogenesis in mice lacking connexin43. Biol Reprod 65: 829-838, 2001.
33. Simon AM, Goodenough DA, Li E, and Paul DL. Female infertility in mice lacking connexin37. Nature 385: 525-529 1997.
34. Stout CE, Costantin JL, Naus CCG, and Charles AC. Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 277: 10482-10488, 2002.
35. Valdimarsson G, De Sousa PA, and Kidder GM. Co-expression of gap junction proteins in the cumulus-oocyte complex. Mol Reprod Dev 36: 7-15, 1993.
36. White TW and Paul DL. Genetic diseases and gene knockouts reveal diverse connexin functions. Annu Rev Physiol 61: 283-310, 1999.
37. Wright CS, Becker DL, Lin JS, Warner AE, and Hardy K. Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation. Reproduction 121: 77-88, 2001.
38. Ya J, Erdtsieck-Ernste EBHW, de Boer PAJ, van Kempen MJA, Jongsma H, Gros D, Moorman AFM, and Lamers WH. Heart defects in connexin43-deficient mice. Circ Res 82: 360-366, 1998.