Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IκB kinase in embryonic hippocampal progenitor cells

Journal of Neuroscience Research

Volumn 71, Issue 5, 2003, Pages 689-700

  Min, Young Kyu ^a   Park, Jae Hyun ^a   Chong, Seon Ah ^b   Kim, Yun Sook ^c   Ahn, Young Soo ^a   Seo, Jeong Taeg ^b   Bae, Young Suk ^c   Chung, Kwang Chul ^d  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Dentistry   (South Korea)

^c Kyungpook National University   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

Akt; CK2; H19 7; I B kinase; JNK; NF B; PDTC; Zinc

Indexed keywords

CASEIN KINASE II; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PYRROLIDINE DITHIOCARBAMATE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; ZINC;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL ACTIVITY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME MECHANISM; GENE ACTIVITY; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIPPOCAMPUS; INTRACELLULAR TRANSPORT; ION TRANSPORT; NERVE CELL; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STEM CELL; SYNAPSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BIOLOGICAL TRANSPORT; CASEIN KINASE II; CELL DEATH; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HIPPOCAMPUS; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; RATS; SIGNAL TRANSDUCTION; STEM CELLS; THIOCARBAMATES; ZINC;

EID: 0037369564     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10520     Document Type: Article

References (51)

1. Ackerman P, Osheroff N. 1989. Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells. J Biol Chem 264:11958-11965.
2. Alvarado-Kristensson M, Porn-Ares MI, Grethe S, Smith D, Zheng L, Andersson T. 2002. p38 Mitogen-activated protein kinase and phosphatidylinositol 3-kinase activities have opposite effects on human neutrophil apoptosis. FASEB J 16:129-131.
3. Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR, Wirth T. 2000. Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 97:4615-4620.
4. Brennan P, O'Neill LA. 1996. 2-Mercaptoethanol restores the ability of nuclear factor kappa B to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrrolidine dithiocarbamate. Biochem J 320:975-981.
5. Carroll D, Marshak DR. 1989. Serum-stimulated cell growth causes oscillations in casein kinase II activity. J Biol Chem 264:7345-7348.
6. Chinery R, Brockman JA, Peeler MO, Shyr Y, Beauchamp RD, Coffey RJ. 1997. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPβ. Nat Med 3:1233-1241.
7. Chung KC, Gomes I, Wang D, Lau LF, Rosner MR. 1998. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol Cell Biol 18:2272-2281.
8. Chung KC, Park JH, Kim CH, Lee HW, Sato N, Uchiyama Y, Ahn YS. 2000. Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinases. J Neurosci Res 59:117-125.
9. Dobrowolska G, Lozeman FJ, Li D, Krebs EG. 1999. CK2, a protein kinase of the next millennium. Mol Cell Biochem 191:3-12.
10. Downward J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267.
11. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
12. 2+ induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-kinase. Mol Pharmacol 59:981-986.
13. 2+. Am J Physiol Cell Physiol 278:C1116-C1125.
14. Eves EM, Tucker MS, Roback JD, Downen M, Rosner MR, Wainer BH. 1992. Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression. Proc Natl Acad Sci USA 89:4373-4377.
15. Galter D, Mihm S, Droge W. 1994. Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1. Eur J Biochem 221:639-648.
16. Gandara DR, Harvey WH, Monaghan GG, Perez EA, Stokes C, Bryson JC, Finn AL, Hesketh PJ. 1992. The delayed-emesis syndrome from cisplatin: phase III evaluation of ondansetron versus placebo. Semin Oncol 19:67-71.
17. Gerber DA, Souquere-Besse S, Puvion F, Dubois MF, Bensaude O, Cochet C. 2000. Heat-induced relocalization of protein kinase CK2. J Biol Chem 275:23919-23926.
18. 2-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol 91:1574-1581.
19. Jeon KI, Jeong JY, Jue DM. 2000. Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. J Immunol 164:5981-5989.
20. Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. 1997. Transcription factor NF-kappaB is activated in primary neurons by amyloid-β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA 94:2642-2647.
21. Karin M. 1999. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 18:6867-6874.
22. Kim CH, Kim JH, Hsu CY, Ahn YS. 1999a. Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-κB activation. FEBS Lett 449:28-32.
23. Kim CH, Kim JH, Xu J, Hsu CY. Ahn YS. 1999b. Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level. J Neurochem 72:1586-1592.
24. Kim CH, Kim JH, Moon SJ, Chung KC, Hsu CY, Seo JT, Ahn YS. 1999c. Pyrithione, a zinc ionophore, inhibits NF-kappaB activation. Biochem Biophys Res Commun 259:505-509.
25. Kim CH, Kim JH, Moon SJ, Hsu CY, Seo JT, Ahn YS. 2000. Biphasic effects of dithiocarbamates on the activity of nuclear factor-κB. Eur J Pharmacol 392:133-136.
26. Kolch W. 2000. Meaningful relationships: the regulation of the Ras/Raf/ MEK/ERK pathway by protein interactions. Biochem J 351:289-305.
27. Kulik G, Klippel A, Weber MJ. 1997. Antiapoptotic signaling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606.
28. Lee FS, Hagler J, Chen ZJ, Maniatis T. 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213-222.
29. Lee JH, Kim JM, Kim MS, Lee YT, Marshak DR, Bae YS. 1997. The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIα by CKII. Biochem Biophys Res Commun 238:462-467.
30. Lipton SA. 1997. Janus faces of NF-κB: neurodestruction versus neuroprotection. Nat Med 3:20-22.
31. Mattson MP, Culmsee C, Yu Z, Camandola S. 2000. Roles of nuclear factor κB in neuronal survival and plasticity. J Neurochem 74:443-456
32. May MJ, Ghosh S. 1999. IκB kinases: kinsmen with different crafts. Science 284:271-273.
33. Misra HP. 1979. Reaction of copper-zinc superoxide dismutase with diethyldithiocarbamate. J Biol Chem 254:11623-11628.
34. Moellering D, McAndrew J, Jo H, Darley-Usmar VM. 1999. Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress. Free Rad Biol Med 26:1138-1145.
35. Nobel CI, Kimland M, Lind B, Orrenius S, Slater AF. 1995. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J Biol Chem 270:26202-26208.
36. Orrenius S, Nobel CS, van den Dobbelsteen DJ, Burkitt MJ, Slater AF. 1996. Dithiocarbamates and the redox regulation of cell death. Biochem Soc Trans 24:1032-1038.
37. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. 1999. NF-κB activation by tumor necrosis factor requires the Akt serinethreonine kinase. Nature 401:82-85.
38. Robinson MJ, Cobb MH. 1997. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9:180-186.
39. Sayed M, Kim SO, Salh BS, Issinger OG, Pelech SL. 2000. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. J Biol Chem 275:16569-16573.
40. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA. 1992. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med 175:1181-1194.
41. 2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J Neurochem 78:600-610.
42. Shumilla JA, Wetterhahn KE, Barchowsky A. 1998. Inhibition of NF-κB binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro. Arch Biochem Biophys 349:356-362.
43. Tsai JC, Jain M, Hsieh CM, Lee WS, Yoshizumi M, Patterson C, Perrella MA, Cooke C, Wang H, Haber E, Schlegel R, Lee ME. 1996. Induction of apoptosis by pyrrolidine dithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem 271:3667-3670.
44. Villa-Moruzzi E, Crabb JW. 1991. Phosphorylation of the catalytic subunit of type-1 protein phosphatase by the v-abl tyrosine kinase. Biochem Biophys Res Commun 177:1019-1024.
45. Wang Z, Jiang C, Ganther H, Lu J. 2001. Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling. Cancer Res 61:7171-7178.
46. Wulczyn FG, Krappmann D, Scheidereit C. 1996. The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation. J Mol Med 74:749-769.
47. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
48. Xu J, Wu Y, He L, Yang Y, Moore SA, Hsu CY. 1997. Regulation of cytokine-induced iNOS expression by a hairpin oligonucleotide in murine cerebral endothelial cells. Biochem Biophys Res Commun 235:394-397.
49. Xu X, Landesman-Bollag E, Channavajhala PL, Seldin DC. 1999. Murine protein kinase CK2: gene and oncogene. Mol Cell Biochem 191:65-74.
50. Yang JP, Merin JP, Nakano T, Kato T, Kitade Y, Okamoto T. 1995. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett 361:89-96.
51. Yoshida A, Yoshida S, Ishibashi T, Kuwano M, Inomata H. 1999. Suppression of retinal neovascularization by the NF-κB inhibitor pyrrolidine dithiocarbamate in mice. Invest Ophthalmol Vis Sci 40:1624-1629.