Synthesis and biological evaluation of 3,4-diaryloxazolones: A new class of orally active cyclooxygenase-2 inhibitors

Journal of Medicinal Chemistry

Volumn 43, Issue 2, 2000, Pages 214-223

  Puig, Carles ^a   Miralpeix, Montserrat ^a   Puig, Jaume ^a   Beleta, Jordi ^a   Huerta, Josep M ^a   López, Manel ^a   Segarra, Victor ^a   Ryder, Hamish ^a   Palacios, José M ^a   Crespo, María I ^a   Godessart, Núria ^a   Feixas, Joan ^a   Ibarzo, Javier ^a   Jiménez, Juan Miguel ^a   Soca, Lídia ^a   Cardelús, Ignasi ^a   Heredia, Ascensión ^a  

^a Research Center ^*  (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 OXO 3 PHENYL 2,3 DIHYDROOXAZOL 4 YL)BENZENESULFONAMIDE; 4 [3 (2 FLUOROPHENYL) 2 OXO 2,3 DIHYDROOXAZOL 4 YL]BENZENESULFONAMIDE; 4 [3 (4 FLUOROPHENYL) 2 OXO 2,3 DIHYDROOXAZOL 4 YL]BENZENESULFONAMIDE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; ROFECOXIB; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERALGESIA; MALE; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CYCLOOXYGENASE INHIBITORS; FEVER; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; OXAZOLES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034719320     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991106b     Document Type: Article

References (24)

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