Synthesis and 5-HT2A antagonist activity of derivatives of the novel heterocycles indolo[3,2-d]pyrrolo[3,2-g]azecine and benzo[d]pyrrolo[3,2-g]azecine compared to the benz[d]indolo[2,3-g]azecine derivative LE 300

Archiv der Pharmazie

Volumn 334, Issue 7, 2001, Pages 241-247

  Rostom, Sherif A F ^a   Farghaly, Ahmed M ^b   Soliman, Farid S G ^c   El Semary, Mona M ^a   Elz, Sigurd ^a   Lehmann, Jochen ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

5 HT2A receptor antagonists; Azecines; Histamine antagonists; LE 300; Serotonin

Indexed keywords

3,6 DIMETHYL 4,5,6,7,8,13 HEXAHYDRO 3H BENZO[D]PYRROLO[3,2 G]AZECINE; 7 METHYL 6,7,8,9,14,15 HEXAHYDRO 5H BENZ[D]INDOLO[2,3 G]AZECINE; BENZ[D]INDOLO[2,3 G]AZECINE DERIVATIVE; BENZO[D]PYRROLO[3,2 G]AZECINE DERIVATIVE; INDOLO[3,2 D]PYRROLO[3,2 G]AZECINE DERIVATIVE; KETANSERIN; LE 300; MEPYRAMINE; QUINOLIZINE DERIVATIVE; SARPOGRELATE; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG; BENZO(D)PYRROLO(3,2 G)AZECINE; BENZO(D)PYRROLO(3,2-G)AZECINE; INDOLE DERIVATIVE; INDOLO(3,2 D)PYRROLO(3,2 G)AZECINE; INDOLO(3,2-D)PYRROLO(3,2-G)AZECINE; PYRROLE DERIVATIVE; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ARTERY; ARTICLE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG STRUCTURE; DRUG SYNTHESIS; ILEUM; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BINDING COMPETITION; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; GUINEA PIG; IN VITRO STUDY; MALE; MUSCLE CONTRACTION; SYNTHESIS; VASCULAR SMOOTH MUSCLE;

ANIMALS; BINDING, COMPETITIVE; GUINEA PIGS; INDOLES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PYRROLES; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0034742145     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4184(200107)334:7<241::AID-ARDP241>3.0.CO;2-B     Document Type: Article

References (23)