Gene replacement therapy in the retinal degeneration slow (rds) mouse: The effect on retinal degeneration following partial transduction of the retina

Human Molecular Genetics

Volumn 10, Issue 21, 2001, Pages 2353-2361

  Sarra, Gian Marco ^a   Stephens, Clare ^a   De Alwis, Mahesh ^b   Bainbridge, James W B ^a   Smith, Alexander J ^a   Thrasher, Adrian J ^b   Ali, Robin R ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE PROTEIN; PERIPHERIN; PERIPHERIN 2; RHODOPSIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ACCURACY; ADENO ASSOCIATED VIRUS; AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL FUNCTION; CELL LOSS; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE THERAPY; GENETIC ANALYSIS; GENETIC TRANSDUCTION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEGENERATION; RETINITIS PIGMENTOSA; TRANSGENE; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; LUMINESCENT PROTEINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED CBA; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; NERVE TISSUE PROTEINS; PHOTORECEPTORS; PIGMENT EPITHELIUM OF EYE; RECOMBINANT FUSION PROTEINS; RETINA; RETINAL DEGENERATION; RETINITIS PIGMENTOSA; TIME FACTORS; TRANSFECTION;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0035504663     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

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4. Absence of receptor outer segments in the retina of rds mutant mice
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6. Development and degeneration of retina in rds mutant mice: The electroretinogram
7. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy
8. Immune responses limit adenovirally-mediated gene expression in the adult mouse eye
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13. Adeno-associated virus gene transfer to mouse retina
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15. High titre recombinant adeno-associated virus production from replicating amplicons and herpes vectors deleted for glycoprotein H