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Volumn 11, Issue 3, 2001, Pages 307-316

Molecular genetics and prospects for therapy of the inherited retinal dystrophies

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE BINDING CASSETTE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CATION; CYCLIC GMP; CYCLIC GMP PHOSPHODIESTERASE; DILTIAZEM; GUANYLATE CYCLASE; GUANYLATE CYCLASE ACTIVATOR; ION CHANNEL; ISOMEROHYDROLASE; LEUCINE ZIPPER PROTEIN; MEPROBAMATE; PROTEIN; RETINOID BINDING PROTEIN; RETINOL; RETINOL DEHYDROGENASE; RETINOL ESTER ISOMEROHYDROLASE; RHODOPSIN; SCLEROPROTEIN; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR; TRANSDUCIN; UNCLASSIFIED DRUG;

EID: 0035371211     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00195-7     Document Type: Review
Times cited : (99)

References (69)
  • 1
    • 0021749124 scopus 로고
    • A study of retinitis pigmentosa in the city of Birmingham- I. Prevalence
    • Bundey S., Crews S.J. A study of retinitis pigmentosa in the city of Birmingham- I. Prevalence. J Med Genet. 21:1984;417-420.
    • (1984) J Med Genet , vol.21 , pp. 417-420
    • Bundey, S.1    Crews, S.J.2
  • 2
    • 0029035306 scopus 로고
    • Retinal photoreceptor dystrophies
    • Bird A.C. Retinal photoreceptor dystrophies. Am J Ophthalmol. 119:1995;543-562.
    • (1995) Am J Ophthalmol , vol.119 , pp. 543-562
    • Bird, A.C.1
  • 4
    • 0027452148 scopus 로고
    • Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa
    • Sung C.-H., Davenport C., Nathans J. Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. J Biol Chem. 268:1993;26645-26649.
    • (1993) J Biol Chem , vol.268 , pp. 26645-26649
    • Sung, C.-H.1    Davenport, C.2    Nathans, J.3
  • 5
    • 0028947938 scopus 로고
    • Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration
    • Tiansen L., Franson W.K., Gordon J.W., Berson E.L., Dryja T.P. Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration. Proc Natl Acad Sci USA. 92:1995;3551-3555.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3551-3555
    • Tiansen, L.1    Franson, W.K.2    Gordon, J.W.3    Berson, E.L.4    Dryja, T.P.5
  • 6
    • 0026522293 scopus 로고
    • Rhodopsin and phototransduction: A model system for G protein-linked receptors
    • Hargrave P.A., McDowell J.H. Rhodopsin and phototransduction: a model system for G protein-linked receptors. FASEB J. 6:1992;2323-2331.
    • (1992) FASEB J , vol.6 , pp. 2323-2331
    • Hargrave, P.A.1    McDowell, J.H.2
  • 7
    • 0029902034 scopus 로고    scopus 로고
    • Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness
    • Dryja T.P., Hahn L.B., Reboul T., Arnaud B. Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nat Genet. 13:1996;358-360.
    • (1996) Nat Genet , vol.13 , pp. 358-360
    • Dryja, T.P.1    Hahn, L.B.2    Reboul, T.3    Arnaud, B.4
  • 8
    • 0024990758 scopus 로고
    • Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase
    • Bowes C., Li T., Danciger M., Baxter L.C., Applebury M.L., Farber D.B. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 347:1990;677-680.
    • (1990) Nature , vol.347 , pp. 677-680
    • Bowes, C.1    Li, T.2    Danciger, M.3    Baxter, L.C.4    Applebury, M.L.5    Farber, D.B.6
  • 9
    • 0027270053 scopus 로고
    • Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa
    • McLaughlin M.E., Sandberg M.A., Berson E.L., Dryja T.R. Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet. 4:1993;130-134.
    • (1993) Nat Genet , vol.4 , pp. 130-134
    • McLaughlin, M.E.1    Sandberg, M.A.2    Berson, E.L.3    Dryja, T.R.4
  • 10
    • 0028820045 scopus 로고
    • Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa
    • Dryja T.P., Finn J.T., Peng Y.-W., McGee T.L., Berson E.L., Yau K.-W. Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa. Proc Natl Acad Sci USA. 92:1995;10177-10181.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10177-10181
    • Dryja, T.P.1    Finn, J.T.2    Peng, Y.-W.3    McGee, T.L.4    Berson, E.L.5    Yau, K.-W.6
  • 12
    • 0034680337 scopus 로고    scopus 로고
    • Impairment of the rod outer segment membrane guanylate cyclase dimerization in a cone-rod dystrophy results in defective calcium signalling
    • Duda T., Venkataraman V., Jankowska A., Lange C., Koch K.W., Sharma R.K. Impairment of the rod outer segment membrane guanylate cyclase dimerization in a cone-rod dystrophy results in defective calcium signalling. Biochemistry. 39:2000;12522-12533.
    • (2000) Biochemistry , vol.39 , pp. 12522-12533
    • Duda, T.1    Venkataraman, V.2    Jankowska, A.3    Lange, C.4    Koch, K.W.5    Sharma, R.K.6
  • 13
    • 0031974462 scopus 로고    scopus 로고
    • A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1
    • Payne A., Downes S., Bessant D., Taylor R., Holder G.E., Warren M.J., Bird A.C., Bhattacharya S.S. A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1. Hum Mol Genet. 7:1998;273-277.
    • (1998) Hum Mol Genet , vol.7 , pp. 273-277
    • Payne, A.1    Downes, S.2    Bessant, D.3    Taylor, R.4    Holder, G.E.5    Warren, M.J.6    Bird, A.C.7    Bhattacharya, S.S.8
  • 14
    • 0026053969 scopus 로고
    • The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane associated glycoprotein
    • Travis G.H., Sutcliffe G., Bok D. The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane associated glycoprotein. Neuron. 6:1991;61-70.
    • (1991) Neuron , vol.6 , pp. 61-70
    • Travis, G.H.1    Sutcliffe, G.2    Bok, D.3
  • 15
    • 0026770736 scopus 로고
    • Molecular cloning of the cDNA for a novel photoreceptor-specific membrane protein (ROM-1) identifies a disk rim protein family implicated in human degenerative retinopathies
    • Bascom R.A., Manara S., Collins L., Molday R.S., Kalnins V.I., McInnes R.R. Molecular cloning of the cDNA for a novel photoreceptor-specific membrane protein (ROM-1) identifies a disk rim protein family implicated in human degenerative retinopathies. Neuron. 8:1992;1171-1184.
    • (1992) Neuron , vol.8 , pp. 1171-1184
    • Bascom, R.A.1    Manara, S.2    Collins, L.3    Molday, R.S.4    Kalnins, V.I.5    McInnes, R.R.6
  • 16
    • 0029842023 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the human peripherin-RDS gene and their involvement in inherited retinal degeneration
    • Keen T.J., Inglehearn C.F. Mutations and polymorphisms in the human peripherin-RDS gene and their involvement in inherited retinal degeneration. Hum Mutat. 8:1996;297-303.
    • (1996) Hum Mutat , vol.8 , pp. 297-303
    • Keen, T.J.1    Inglehearn, C.F.2
  • 17
    • 0028245437 scopus 로고
    • Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci
    • Kajiwara K., Berson E.L., Dryja T.R. Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci. Science. 264:1994;1604-1608.
    • (1994) Science , vol.264 , pp. 1604-1608
    • Kajiwara, K.1    Berson, E.L.2    Dryja, T.R.3
  • 18
    • 0034058474 scopus 로고    scopus 로고
    • Expression and characterization of peripherin/RDS-ROM-1 complexes and mutants implicated in retinal degenerative diseases
    • The title of this paper says it all.
    • Goldberg A.F., Molday R.S. Expression and characterization of peripherin/RDS-ROM-1 complexes and mutants implicated in retinal degenerative diseases. Methods Enzymol. 316:2000;671-687. The title of this paper says it all.
    • (2000) Methods Enzymol , vol.316 , pp. 671-687
    • Goldberg, A.F.1    Molday, R.S.2
  • 20
    • 0033033364 scopus 로고    scopus 로고
    • Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus
    • Yamamoto H., Simon A., Eriksson U., Harris E., Berson E.L., Dryja T.P. Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus. Nat Genet. 22:1999;188-191.
    • (1999) Nat Genet , vol.22 , pp. 188-191
    • Yamamoto, H.1    Simon, A.2    Eriksson, U.3    Harris, E.4    Berson, E.L.5    Dryja, T.P.6
  • 28
    • 0030983124 scopus 로고    scopus 로고
    • The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR)
    • Azarian S.M., Travis G.H. The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR). FEBS Lett. 409:1997;247-252.
    • (1997) FEBS Lett , vol.409 , pp. 247-252
    • Azarian, S.M.1    Travis, G.H.2
  • 29
    • 0030969303 scopus 로고    scopus 로고
    • The 220 kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily
    • Illing M., Molday L.L., Molday R.S. The 220 kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. J Biol Chem. 272:1997;10303-10310.
    • (1997) J Biol Chem , vol.272 , pp. 10303-10310
    • Illing, M.1    Molday, L.L.2    Molday, R.S.3
  • 30
    • 0033538438 scopus 로고    scopus 로고
    • Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
    • Weng J., Mata N.L., Azarian S.M., Tzekov R.D., Birch D.G., Travis G.H. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell. 98:1999;13-23.
    • (1999) Cell , vol.98 , pp. 13-23
    • Weng, J.1    Mata, N.L.2    Azarian, S.M.3    Tzekov, R.D.4    Birch, D.G.5    Travis, G.H.6
  • 31
    • 0034671726 scopus 로고    scopus 로고
    • Age-related macular degeneration: The lipofuscin component A2E detaches pro-apoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells
    • epub ahead of print
    • Suter M, Reme CE, Grimm C, Wenzel A, Jaattela M, Esser P, Kociok N, Leist M, Richter C: Age-related macular degeneration: The lipofuscin component A2E detaches pro-apoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem 2000 [epub ahead of print].
    • (2000) J Biol Chem
    • Suter, M.1    Reme, C.E.2    Grimm, C.3    Wenzel, A.4    Jaattela, M.5    Esser, P.6    Kociok, N.7    Leist, M.8    Richter, C.9
  • 34
    • 0029790558 scopus 로고    scopus 로고
    • Transcription factor genes and the developing eye: A genetic perspective
    • Freund C., Horsford D.J., McInnes R.R. Transcription factor genes and the developing eye: a genetic perspective. Hum Mol Genet. 5:1996;1471-1488.
    • (1996) Hum Mol Genet , vol.5 , pp. 1471-1488
    • Freund, C.1    Horsford, D.J.2    McInnes, R.R.3
  • 35
    • 0030781996 scopus 로고    scopus 로고
    • Crx, a novel Otx-like paired homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    • Chen S., Wang Q.L., Nie Z., Sun H., Lennon G., Copeland N.G., Gilbert D.J., Jenkins N.A., Zack D.J. Crx, a novel Otx-like paired homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 19:1997;1017-1030.
    • (1997) Neuron , vol.19 , pp. 1017-1030
    • Chen, S.1    Wang, Q.L.2    Nie, Z.3    Sun, H.4    Lennon, G.5    Copeland, N.G.6    Gilbert, D.J.7    Jenkins, N.A.8    Zack, D.J.9
  • 38
    • 0026463972 scopus 로고
    • Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of retinitis pigmentosa
    • Olsson J.E., Gordon J.W., Pawlyk B.S., et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of retinitis pigmentosa. Neuron. 9:1992;815-830.
    • (1992) Neuron , vol.9 , pp. 815-830
    • Olsson, J.E.1    Gordon, J.W.2    Pawlyk, B.S.3
  • 39
    • 0030669568 scopus 로고    scopus 로고
    • Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for photoreceptorspecific homeobox gene (CRX) essential for maintenance of the photoreceptor
    • Freund C.L., Gregory-Evans C.Y., Furukawa T., Papaioannou M., Looser J., Ploder L., Bellingham J., Ng D., Herbrick J.A., Duncan A. Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for photoreceptorspecific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell. 91:1997;543-553.
    • (1997) Cell , vol.91 , pp. 543-553
    • Freund, C.L.1    Gregory-Evans, C.Y.2    Furukawa, T.3    Papaioannou, M.4    Looser, J.5    Ploder, L.6    Bellingham, J.7    Ng, D.8    Herbrick, J.A.9    Duncan, A.10
  • 41
    • 0030725687 scopus 로고    scopus 로고
    • Crx, a novel Otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation
    • Furukawa T., Morrow E.M., Cepko C.L. Crx, a novel Otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell. 91:1997;531-541.
    • (1997) Cell , vol.91 , pp. 531-541
    • Furukawa, T.1    Morrow, E.M.2    Cepko, C.L.3
  • 43
    • 0033739625 scopus 로고    scopus 로고
    • Bestrophin, the product of the best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium
    • Marmorstein A.D., Marmorstein L.Y., Rayborn M., Wang X., Hollyfield J.G., Petrukhin K. Bestrophin, the product of the best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium. Proc Natl Acad Sci USA. 97:2000;12758-12763.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12758-12763
    • Marmorstein, A.D.1    Marmorstein, L.Y.2    Rayborn, M.3    Wang, X.4    Hollyfield, J.G.5    Petrukhin, K.6
  • 45
    • 0034284508 scopus 로고    scopus 로고
    • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors
    • Roepman R., Bernoud-Hubac N., Schick D.E., Maugeri A., Berger W., Ropers H.H., Cremers F.P., Ferreira P.A. The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. Hum Mol Genet. 9:2000;2095-2105.
    • (2000) Hum Mol Genet , vol.9 , pp. 2095-2105
    • Roepman, R.1    Bernoud-Hubac, N.2    Schick, D.E.3    Maugeri, A.4    Berger, W.5    Ropers, H.H.6    Cremers, F.P.7    Ferreira, P.A.8
  • 46
    • 0033757376 scopus 로고    scopus 로고
    • Nutrition and retinal degenerations
    • Berson E.L. Nutrition and retinal degenerations. Int Ophthalmol Clin. 40:2000;93-111.
    • (2000) Int Ophthalmol Clin , vol.40 , pp. 93-111
    • Berson, E.L.1
  • 47
    • 0032881941 scopus 로고    scopus 로고
    • Retinitis pigmentosa: Rod photoreceptor rescue by a calcium-channel blocker in the rd mouse
    • Frasson M., Sahel J.A., Fabre M., Simonutti M., Dreyfus H., Picaud S. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med. 5:1999;1183-1187.
    • (1999) Nat Med , vol.5 , pp. 1183-1187
    • Frasson, M.1    Sahel, J.A.2    Fabre, M.3    Simonutti, M.4    Dreyfus, H.5    Picaud, S.6
  • 48
    • 0033861507 scopus 로고    scopus 로고
    • The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro23His rat
    • Bush R.A., Kononen L., Machida S., Sieving P.A. The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro23His rat. Invest Ophthalmol Vis Sci. 41:2000;2697-2701.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 2697-2701
    • Bush, R.A.1    Kononen, L.2    Machida, S.3    Sieving, P.A.4
  • 50
    • 0026462896 scopus 로고
    • Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
    • LaVail M.M., Unoki K., Yasumura D., Matthes M.T., Yancopoulos G.D., Steinberg R.H. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci USA. 89:1992;11249-11253.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11249-11253
    • Lavail, M.M.1    Unoki, K.2    Yasumura, D.3    Matthes, M.T.4    Yancopoulos, G.D.5    Steinberg, R.H.6
  • 54
  • 55
    • 0033947697 scopus 로고    scopus 로고
    • Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy
    • Restoration of photoreceptor structural integrity and function in the rds mouse by gene therapy with an rds transgene. (See [54•,57•] for further examples of gene therapy.)
    • Ali R.R., Sarra G.M., Stephens C., Alwis M.D., Bainbridge J.W., Munro P.M., Fauser S., Reichel M.B., Kinnon C., Hunt D.M. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nat Genet. 25:2000;306-310. Restoration of photoreceptor structural integrity and function in the rds mouse by gene therapy with an rds transgene. (See [54•,57•] for further examples of gene therapy.).
    • (2000) Nat Genet , vol.25 , pp. 306-310
    • Ali, R.R.1    Sarra, G.M.2    Stephens, C.3    Alwis, M.D.4    Bainbridge, J.W.5    Munro, P.M.6    Fauser, S.7    Reichel, M.B.8    Kinnon, C.9    Hunt, D.M.10
  • 56
    • 0034633619 scopus 로고    scopus 로고
    • Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Long-term survival and late-stage therapy
    • The authors describe long-term rescue of photoreceptors in the rhodopsin P23H transgenic rat.
    • LaVail M.M., Yasumura D., Matthes M.T., Drenser K.A., Flannery J.G., Lewin A.S., Hauswirth W.W. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc Natl Acad Sci USA. 97:2000;11488-11493. The authors describe long-term rescue of photoreceptors in the rhodopsin P23H transgenic rat.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11488-11493
    • Lavail, M.M.1    Yasumura, D.2    Matthes, M.T.3    Drenser, K.A.4    Flannery, J.G.5    Lewin, A.S.6    Hauswirth, W.W.7
  • 60
  • 61
    • 0032143956 scopus 로고    scopus 로고
    • Visual field loss in RCS rats and the effect of RPE cell transplantation
    • Sauve Y., Klassen H., Whiteley S.J.O., Lund R.D. Visual field loss in RCS rats and the effect of RPE cell transplantation. Exp Neurol. 152:1998;243-250.
    • (1998) Exp Neurol , vol.152 , pp. 243-250
    • Sauve, Y.1    Klassen, H.2    Whiteley, S.J.O.3    Lund, R.D.4
  • 62
    • 0032830443 scopus 로고    scopus 로고
    • Photoreceptor layer reconstruction in a rodent model of retinal degeneration
    • Kwan A.S., Wang S., Lund R.D. Photoreceptor layer reconstruction in a rodent model of retinal degeneration. Exp Neurol. 159:1999;21-33.
    • (1999) Exp Neurol , vol.159 , pp. 21-33
    • Kwan, A.S.1    Wang, S.2    Lund, R.D.3
  • 63
    • 0034712109 scopus 로고    scopus 로고
    • Out of Eden: Stem cells and their niches
    • Watt F.M., Hogan B.L. Out of Eden: stem cells and their niches. Science. 287:2000;1427-1430.
    • (2000) Science , vol.287 , pp. 1427-1430
    • Watt, F.M.1    Hogan, B.L.2
  • 66
    • 0033781861 scopus 로고    scopus 로고
    • Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats
    • Young M.J., Ray J., Whiteley S.J., Klassen H., Gage F.H. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci. 3:2000;197-205.
    • (2000) Mol Cell Neurosci , vol.3 , pp. 197-205
    • Young, M.J.1    Ray, J.2    Whiteley, S.J.3    Klassen, H.4    Gage, F.H.5
  • 68
    • 0034677891 scopus 로고    scopus 로고
    • Retinal stem cells in the adult mammalian eye
    • In this study, the authors transplanted stem cells, rather than RPE cells, to repair a damaged mouse retina in vivo. This approach may have relevance to the treatment of human disease.
    • Tropepe V., Coles B.L., Chiasson B.J., Horsford D.J., Elia A.J., McInnes R.R., van der Kooy D. Retinal stem cells in the adult mammalian eye. Science. 17:2000;2032-2036. In this study, the authors transplanted stem cells, rather than RPE cells, to repair a damaged mouse retina in vivo. This approach may have relevance to the treatment of human disease.
    • (2000) Science , vol.17 , pp. 2032-2036
    • Tropepe, V.1    Coles, B.L.2    Chiasson, B.J.3    Horsford, D.J.4    Elia, A.J.5    McInnes, R.R.6    Van Der Kooy, D.7
  • 69
    • 0345363056 scopus 로고    scopus 로고
    • Development of a silicon retinal implant: Cortical evoked potentials following focal stimulation of the rabbit retina with light and electricity
    • Nadig M.N. Development of a silicon retinal implant: cortical evoked potentials following focal stimulation of the rabbit retina with light and electricity. Clin Neurophysiol. 110:1999;1545-1553.
    • (1999) Clin Neurophysiol , vol.110 , pp. 1545-1553
    • Nadig, M.N.1


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