Acetaminophen exhibits weak antiestrogenic activity in human endometrial adenocarcinoma (Ishikawa) cells

Toxicological Sciences

Volumn 72, Issue 1, 2003, Pages 57-65

  Dowdy, Janet ^a   Brower, Stacey ^a   Miller, Michael R ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Acetaminophen; Alkaline phosphatase; Endocrine disruption; Estrogen receptors; Ishikawa cells

Indexed keywords

4 HYDROXYTAMOXIFEN; ALKALINE PHOSPHATASE; CELL PROTEIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LACTATE DEHYDROGENASE; PARACETAMOL;

ARTICLE; BINDING COMPETITION; BINDING SITE; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; ENDOMETRIUM CARCINOMA; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME RELEASE; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN EXPRESSION; SPECTROPHOTOMETRY;

ACETAMINOPHEN; ADENOCARCINOMA; ALKALINE PHOSPHATASE; ANALGESICS, NON-NARCOTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIAL NEOPLASMS; ENZYME INDUCTION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; L-LACTATE DEHYDROGENASE; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED;

EID: 0037340686     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg005     Document Type: Article

References (46)

1. Albert, J. L., Sundstrom, S. A., and Lyttle C. R. (1990). Estrogen regulation of placental alkaline phosphatase gene expression in a human endometrial adenocarcinoma cell line. Cancer Res. 50, 3306-3310.
2. Bhat, K. P. L., and Pezzuto, J. M. (2001). Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 61, 6137-6144.
3. Bilir, A., Altinoz, M. A., Attar, E., Erkan, M., and Aydiner, A. (2002). Acetaminophen modulations of chemotherapy efficacy in MDAH 2774 human endometrioid ovarian cancer cells in vitro. Neoplasma 49, 38-42.
4. Boulares, H. A., Giardina, C., Navarro, C. L., Khairallah, E. A., and Cohen, S. D. (1999). Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: An inhibition of c-myc expression, NF-κB activation and raf-1 kinase activity. Toxicol. Sci. 48, 264-274.
5. Chandrasekharan, N. V., Dai, H., Roos, K. L., Evanson, N. K., Tomsik, J., Elton, T. S., and Simmons, D.L. (2002). COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc. Natl. Acad. Sci. U.S.A. 99, 13926-13931.
6. Cramer, D. W., Harlow, B. L., Titus-Ernstoff, L., Bohlke, K., Welch, W. R., and Greenberg, E. R. (1998a). Over-the-counter analgesics and risk of ovarian cancer. Lancet 10, 104-107.
7. Cramer, D. W., Liberman, R. F., Hornstein, M. D., McShane, P., Powers, D., Li, E. Y., and Barbieri, R. (1998b). Basal hormone levels in women who use acetaminophen for menstrual pain. Fertil. Steril. 70, 371-373.
8. Dai, Y., and Cederbaum, A. J. (1995). Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. Pharmacol. Exp. Ther. 273, 1497-1505.
9. Enmark, E., Pelto-Huikko, M., Grandien, K. A. J., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjold, M., and Gustafsson, J.-A. (1997). Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82, 4258-4265.
10. Gadd, S., Hobbs, G., and Miller, M. R. (2002). Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-κB activity. Toxicol. Sci. 66, 233-243.
11. Harnagea-Theophilus, E., and Miller, M. R. (1998). Acetaminophen alters estrogenic responses in vitro: Stimulation of DNA synthesis in estrogen-responsive human breast cancer cells. Toxicol. Sci. 46, 38-44.
12. Harnagea-Theophilus, E., Gadd, S. L., Knight-Trent, A. H., DeGeorge, G. L., and Miller, M. R. (1999a). Acetaminophen-induced proliferation of breast cancer cells involves estrogen receptors. Toxicol. Appl. Pharmacol. 155, 273-279.
13. Harnagea-Theophilus, E., Miller, M. R., and Rao, N. (1999b). Positional isomers of acetaminophen differentially induce proliferation of cultured breast cancer cells. Toxicol. Lett. 104, 11-18.
14. Holinka, C. F., Anzai, Y., Hata, H., Kimmel, N., Kuramoto, H., and Gurpide, E. (1989). Proliferation and responsiveness to estrogen of human endometrial cancer cells under serum-free culture conditions. Cancer Res. 49, 3297-3301.
15. Holinka, C. F., Hata, H., Gravanis, A., Kuramoto, H., and Gurpide, E. (1986a). Effects of estradiol on proliferation of endometrial adenocarcinoma cells (Ishikawa line). J. Steroid Biochem. 25, 781-786.
16. Holinka, C. F., Hata, H., Kuramoto, H., and Gurpide, E. (1986b). Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa line). Cancer Res. 46, 2771-2774.
17. Holme, J. A., Hongslo, J. K., Bjornstad, C., Harvison, P. J., and Nelson, S. D. (1988). Toxic effects of paracetamol and related structures in V79 Chinese hamster cells. Mutagenesis 3, 51-56.
18. Honglso, J. K., Brogger, A., Bjorge, C., and Holme, J. A. (1991). Increased frequency of sister-chromatid exchange and chromatid breaks in lymphocytes after treatment of human volunteers with therapeutic doses of paracetamol. Mutat. Res. 261, 1-8.
19. Hongslo, J. K., Smith, C. V., Brunborg, G., Soderlund, E. J., and Holme, J. A. (1994). Genotoxicity of paracetamol in mice and rats. Mutagenesis 9, 93-100.
20. Isenhower, W. D., Jr., Newbold, R. R., Cefalo, R. C., Korach, K. S., and McLachlan, J. A. (1986). Absence of estrogenic activity in some drugs commonly used during pregnancy. Biol. Res. Pregnancy Perinatol. 7, 6-10.
21. Kappers, W. A., Van Och, F. M., De Groene, E. M., and Horbach, G. J. (2000). Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons. Mutat. Res. 466, 143-159.
22. Kassan, S., Mechanick, J. I., and Gurpide, E. (1989). Altered estrogen receptor system in estrogen-unresponsive human endometrial adenocarcinoma cells. J. Steroid Biochem. 33, 327-333.
23. Keller, H., Givel, F., Perroud, M., and Wahli, W. (1995). Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol. 9, 794-804.
24. Kuiper, G. G., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S., and Gustafsson, J. A. (1997). Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138, 863-870.
25. Lee, M. J., Gee, P., and Beard, S. E. (1997). Detection of peroxisome proliferators using a reporter construct derived from the rat acyl-CoA oxidase promoter in the rat liver cell line H-4-II-E. Cancer Res. 57, 1575-1579.
26. Littlefield, B. A., Gurpide, E., Markiewicz, L., McKinley, B., and Hochberg, R. B. (1990) A simple and sensitive microtiter plate estrogen bioassay based on stimulation of alkaline phosphatase in Ishikawa cells: Estrogenic action of delta 5 adrenal steroids. Endocrinology 127, 2757-2762.
27. Makrigiannakis, A., Margioris, A., Markogiannakis, E., Stournaras, C., and Gravanis, A. (1992) Steroid hormones regulate the release of immunoreactive beta-endorphin from the Ishikawa human endometrial cell line. J. Clin. Endocrinol. Metab. 75, 584-589.
28. Markogiannakis, E., Georgoulias, V., Margioris, A. N., Zoumakis, E., Stournaras, C., and Gravanis, A. (1997). Estrogens and glucocorticoids induce the expression of c-erbB2/NEU receptor in Ishikawa human endometrial cells. Life Sci. 61, 1083-1095.
29. Miller, M. R., Wentz, E., and Ong, S. (1999). Acetaminophen alters estrogenic responses in vitro: Inhibition of estrogen-dependent vitellogenin production in trout liver cells. Toxicol. Sci. 48, 30-37.
30. Nishada, M., Kasahara, K., Kaneko, M., and Iwasaki, H. (1985). Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors. Acta Obst. Gynaec. Jpn. 37, 1103-1111.
31. Nunez, S. B., Medin, J. A., Braissant, O., Kemp, L., Wahli, W., Ozato, K., and Segars J. H. (1997). Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor. Mol. Cell. Endocrinol. 127, 27-40.
32. Orth, K., Hung, J., Gazdar, A., Bowcock, A., Mathis, J. M., and Sambrook, J. (1994). Genetic instability in human ovarian cancer cell lines. Proc. Natl. Acad. Sci. U.S.A. 91, 9495-9499.
33. Paech, K., Webb, P., Kuiper, G. G., Nilsson, S., Gustafsson, J., Kushner P. J., and Scanlan, T. S. (1997). Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277, 1508-1510.
34. Patel, R., and Rosengren, R. J. (2001). Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse. Toxicol. Lett. 122, 89-96.
35. Prescott, L. (1996). Paracetamol (Acetaminophen): A Critical Biographical Review. Taylor and Francis, London.
36. Reeves, W. J., and Fimognari, G. M. (1966). Lactic dehydrogenase: heart. In Methods in Enzymology, Vol. 9 (W. A. Wood, Ed.), pp. 288-294. Academic Press, New York.
37. Reilly, T. P., Brady, J. N., Marchick, M. R., Bourdi, M., George, J. W., Radonovich, M. F., Pise-Masison, C. A., and Pohl, L. R. (2001). A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. Chem. Res. Toxicol. 14, 1620-1628.
38. Santoso, J. T., Tang, D. C., Lane, S. B., Hung, J., Reed, D. J., Muller, C. Y., Carbone, D. P., Lucci, J. A., Miller, D. S., and Mathis, J. M. (1995). Adenovirus based p53 gene therapy in ovarian cancer. Gynecol. Oncol. 59, 171-178.
39. Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Gronert, K., and Chiang, N. (2000). Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: A novel mechanism for NSAID and N-3 PUFA therapeutic actions. J. Physiol. Pharmacol. 51, 643-654.
40. Simard, J., Sanchez, R., Poirier, D., Gauthier, S., Singh, S. M., Merand, Y., Belanger, A., Labrie, C., and Labrie, F. (1997). Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells. Cancer Res. 57, 3494-3497.
41. Strobl, J. S., Peterson, V. A., and Woodfork, K. A. (1994). A survey of human breast cancer sensitivity to growth inhibition by calmodulin antagonists in tissue culture. Biochem. Pharmacol. 47, 2157-2161.
42. Thompson, M. A., Adelson, M. D., and Kaufman, L. M. (1991). Lupton retards proliferation of ovarian epithelial tumor cells cultured in serum-free medium. J. Clin. Endocrinol. Metab. 72, 1036-1041.
43. Udenfriend, S., Stein, S., Bohlen, P., Dairman, W., Leimgruber, W., and Weigele, M. (1972). Fluorescamine: A reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range. Science 178, 871-872.
44. Wade, C. B., Robinson, S., Shapiro, R. A., and Dorsa, D. M. (2001). Estrogen receptor (ER)α and ERβ exhibit unique pharmacologic properties when coupled to activation of the mitogen-activated protein kinase pathway. Endocrinology 142, 2336-2342.
45. Wiger, R., Finstad, H. S., Hongslo, J. K., Haug, K., and Holme, J. A. (1997). Paracetamol inhibits cell cycling and induces apoptosis in HL-60 cells. Pharmacol. Toxicol. 81, 285-293.
46. Wiger, R., Hongslo, J. K., Evenson, D. P., De Angelis, P., Schwarze, P. E., and Holme, J. A. (1995). Effects of acetaminophen and hydroxyurea on spermatogenesis and sperm chromatin structure in laboratory mice. Reprod. Toxicol. 9, 21-33.