Estrogen receptor (ER)α and ERβ exhibit unique pharmacologic properties when coupled to activation of the mitogen-activated protein kinase pathway

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2336-2342

  Wade, Christian B ^a   Robinson, Siobhan ^a   Shapiro, Robert A ^a   Dorsa, Daniel M ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE; TAMOXIFEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; GENE ACTIVATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0035024595     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8071     Document Type: Article

References (34)

1. 1. Webb P, Lopez GN, Uht RM, Kushner PJ 1995 Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9:443-456
2. 2. Revelli A, Tesarik J, Massobrio M 1998 Nongenomic effects of neurosteroids. Gynecol Endocrinol 12:61-67
3. 3. Morley P, Whitfield JF, Vanderhyden BC, Tsang BK, Schwartz JL 1992 A new, nongenomic estrogen action: the rapid release of intracellular calcium. Endocrinology 131:1305-1312
4. 4. Aronica SM, Kraus WL, Katzenellenbogen BS 1994 Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91:8517-8521
5. 5. Watters JJ, Dorsa DM 1998 Transcriptional effects of estrogen on neuronal neurotensin gene expression involve cAMP/protein kinase A-dependent signaling mechanisms. J Neurosci 18:6672-6680
6. 6. Mermelstein PG, Becker JB, Surmeier DJ 1996 Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci 16:595-604
7. 7. Nadal A, Rovira JM, Laribi O, Leon-quinto T, Andreu E, Ripoll C, Soria B 1998 Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB J 12:1341-1348
8. 8. Gu Q, Moss RL 1996 17 beta-Estradiol potentiates kainate-induced currents via activation of the cAMP cascade. J Neurosci 16:3620-3629
9. 9. Zhou Y, Watters JJ, Dorsa DM 1996 Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain. Endocrinology 137:2163-2166
10. 10. Migliaccio A, Di Domenico M, Castoria G, de Falco A, Bontempo P, Nola E, Auricchio F 1996 Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 15:1292-1300
11. 11. Watters JJ, Campbell JS, Cunningham MJ, Krebs EG, Dorsa DM 1997 Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signaling cascade and c-fos immediate early gene transcription. Endocrinology 138:4030-4033
12. 12. Singer CA, Figueroa-Masot XA, Batchelor RH, Dorsa DM 1999 The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 19:2455-2463
13. 13. Ramirez VD, Zheng J 1996 Membrane sex-steroid receptors in the brain. Front Neuroendocrinol 17:402-439
14. 14. Razandi M, Pedram A, Greene GL, Levin ER 1999 Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol Endocrinol 13:307-319
15. 15. Singer CA, Rogers KL, Strickland TM, Dorsa DM 1996 Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci Lett 212:13-16
16. 16. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P 1987 Functional domains of the human estrogen receptor. Cell 51:941-951
17. 17. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA 1996 Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930
18. 18. Yao H, York RD, Misra-Press A, Carr DW, Stork PJ 1998 The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor. J Biol Chem 273:8240-8247
19. 19. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS 1997 Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277:1508-1510
20. 20. Shapiro RA, Xu C, Dorsa DM 2000 Differential transcriptional regulation of rat vasopressin gene expression by estrogen receptor (alpha) and (beta). Endocrinology 141:4056-4064
21. 21. Green PS, Bishop J, Simpkins JW 1997 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells. J Neurosci 17:511-515
22. 22. Ramirez VD, Zheng J, Siddique KM 1996 Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: fantasy or reality. Cell Mol Neurobiol 16:175-198
23. 23. Pietras RJ, Szego CM 1979 Metabolic and proliferative responses to estrogen by hepatocytes selected for plasma membrane binding-sites specific for estradiol-17beta. J Cell Physiol 98:145-159
24. 24. Pappas TC, Gametchu B, Watson CS 1995 Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding. FASEB J 9:404-410
25. 25. Stevis PE, Deecher DC, Suhadolnik L, Mallis LM, Frail DE 1999 Differential effects of estradiol and estradiol-BSA conjugates. Endocrinology 140:5455-5458
26. 26. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A, Auricchio F 1999 Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J 18:2500-2510
27. 27. Singh M, Setalo Jr G, Guan X, Warren M, Toran-Allerand CD 1999 Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci 19:1179-1188
28. 28. McEwen BS, Alves SE 1999 Estrogen actions in the central nervous system. Endocr Rev 20:279-307
29. 29. Cowley SM, Hoare S, Mosselman S, Parker MG 1997 Estrogen receptors alpha and beta form heterodimers on DNA. J Biol Chem 272:19858-19862
30. 30. Shughrue PJ, Lane MV, Merchenthaler I 1997 Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525
31. 31. Fawell SE, White R, Hoare S, Sydenham M, Page M, Parker MG 1990 Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci USA 87:6883-6887
32. 32. Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson J, Nilsson S 1998 Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol 54:105-112
33. 33. Han HJ, Lee YH, Park SH 2000 Estradiol-17beta-BSA stimulates Ca(2+) uptake through nongenomic pathways in primary rabbit kidney proximal tubule cells: involvement of cAMP and PKC. J Cell Physiol 183:37-44
34. 34. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambron P 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270:1491-1494