Detection of peroxisome proliferators using a reporter construct derived from the rat acyl-CoA oxidase promoter in the rat liver cell line H-4-II-E

Cancer Research

Volumn 57, Issue 8, 1997, Pages 1575-1579

  Lee, Michael J ^a   Gee, Pauline ^a   Beard, Shannon E ^a  

^a Xenometrix Inc USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOANTHRACENE; 4 NITROQUINOLINE 1 OXIDE; ACETYLSALICYLIC ACID; ACYL COENZYME A OXIDASE; ANALGESIC AGENT; ANTILIPEMIC AGENT; CARCINOGEN; CHLORAMPHENICOL ACETYLTRANSFERASE; CLOFIBRATE; DIETHYLSTILBESTROL; FENBUFEN; HERBICIDE; IBUPROFEN; MESYLIC ACID ETHYL ESTER; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PEROXISOME PROLIFERATOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PIRINIXIC ACID; PLASTICIZER;

AMES TEST; ANIMAL CELL; ARTICLE; BIOASSAY; CARCINOGENICITY; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE FUSION; GENE INDUCTION; GENOTOXICITY; HEPATOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; TRANSCRIPTION REGULATION; TUMOR GROWTH;

ACYL-COA OXIDASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CARCINOGENICITY TESTS; CARCINOGENS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; ENZYME INDUCTION; GENES, REPORTER; LIVER NEOPLASMS; OXIDOREDUCTASES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0030960656     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Rao, M. S., and Reddy, J. K. An overview of peroxisome proliferator-induced hepatocarcinogenesis. Environ. Health Perspect, 93: 205-209, 1991.
2. Rao, M. S., and Reddy, J. K. Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis (Lond.), 8: 631-636, 1987.
3. 2-generating peroxisomal fatty acyl-CoA oxidase. Proc. Natl. Acad. Sci. USA, 92: 7080-7084, 1995.
4. Reddy, J. K., Azarnoff, D. I., and Hignite, C. E. Hypolipidemic hepatic peroxisome proliferators form a novel class of carcinogens. Nature (Lond.), 283: 397-398, 1980.
5. Cohen, A. J., and Grasso, P. Review of the hepatic response to hypolipidemic drugs in rodents and assessment of its toxicological significance to man. Food Cosmet. Toxicol., 19: 585-599, 1981.
6. Mukherjee, R., Jow, L., Noonan, D., and McDonnell, D. P. Human and rat peroxisome proliferator-activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J. Steroid Biochem. Mol. Biol., 51: 157-166, 1994.
7. Barrett, J. C. Mechanisms for species differences in receptor-mediated carcinogenesis. Mutat. Res., 333: 189-202, 1995.
8. Foxworthy, P. S., and Eacho, P. I. Cultured hepatocytes for studies of peroxisome proliferation: methods and applications. J. Pharmacol. Toxicol. Methods, 31: 21-30, 1994.
9. Ashby, J., Brady, A., Elcombe, C. R., Elliott, B. M., Ishmael, J., Odum, J., Tugwood, J. D., Kettle, S., and Purchase, I. F. H. Mechanistically based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol., 13 (S2): S1-S101, 1994.
10. Lake, B. Hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals. Annu. Rev. Pharmacol. Toxicol., 35: 483-501 1995.
11. Nemali, M. R., Reddy, M. K., Usuda, N., Reddy, P. G., Comeau, L. D., Rao, M. S., and Reddy, J. K. Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens. Toxicol. Appl. Pharmacol., 97: 72-87, 1989.
12. Issemann, I., and Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond.), 347: 646-650, 1990.
13. Levin, A. A., Sturenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., and Grippo, J. F. 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXR-α, Nature (Lond.), 355: 359-361, 1992.
14. Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation with their receptors. Nature (Lond.), 358: 771-774, 1992.
15. Gearing, K. L., Gottlicher, M., Teboul, M., Widmark, E., and Gustafsson, J. A. Interaction of the peroxisome proliferator-activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA, 90: 1440-1444, 1993.
16. Miyata, K. S., McCaw, S. E., Marcus, S. L., Rachubinski, R. A., and Capone, J. P. The peroxisome proliferator-activated receptor interacts with the retinoid X receptor in vivo. Gene (Amst.), 148: 327-330, 1994.
17. Reddy, J. K., Goel, S. K., Nemali, M. R., Carrino, J. J., Laffler, T. G., Reddy, M. K., Sperbeck, S. J., Osumi, T., Hashimoto, T., Lalwani, N. D., and Rao, M. S. Transcriptional regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc. Natl. Acad. Sci. USA, 83: 1747-1751, 1986.
18. Varanasi, U., Chu, R., Huang, Q., Castellon, R., Yeldandi, A. V., and Reddy, J. K. Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J. Biol. Chem., 271: 2147-2155, 1996.
19. Todd, M. D., Lee, M. J., Williams, J. L., Nalezny, J. M., Gee, P., Benjamin, M. B., and Farr, S. B. The CAT-Tox (L) assay: a sensitive and specific measure of stress-induced transcription in transformed human liver cells. Fundam. Appl. Toxicol., 28: 118-128, 1995.
20. Krey, G., Mahfoundi, A., and Wahli, W. Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl coenzyme A oxidase promoter. Mol. Endocrinol., 9: 219-231, 1995.
21. Sakurai, T., Miyazawa, S., Osumi, T., Furuta, S., and Hashimoto, T. Induction of peroxisomal β-oxidation by the administration of acetylsalicylic acid. Toxicol. Appl. Pharmacol., 59: 8-14, 1981.
22. Dinis, T. C. P., Madeira, V. M. C., and Almeida L. M. Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and peroxyl radical scavengers. Arch. Biochem. Biophys. 315: 161-169, 1994.
23. Cai, Y., Appelvist, E. L., and DePierre, J. W. Hepatic oxidative stress and related defenses during treatment of mice with acetylsalicylic acid and other peroxisome proliferators. J. Biochem. Toxicol., 10: 87-94, 1995.
24. Cai, Y., Nelson, B. D., Li, R., Luciakova, K., and DePierre, J. W. Thyrometic action of the peroxisome proliferators clofibrate, perfluorooctanoic acid, and acetylsalicylic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis. Arch. Biochem. Biophys., 325: 107-112, 1996.
25. Rekka, E., Ayalogu, E. O., Lewis, D. F., Gibson, G. G., and Ioannides, C. Induction of hepatic microsomal CYP4A activity and of peroxisomal β-oxidation by two non-steroidal anti-inflammatory drugs. Arch. Toxicol., 68: 73-78, 1994.
26. Blumberg, P. M. In vitro studies on the mode of action of the phorbol esters, potent tumor promoters. CRC Crit. Rev. Toxicol., 8: 199-228, 1981.
27. Hwang, J. J., Hsia, M. T. S., and Jirtle, R. L. Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human lymphocytes by the peroxisome proliferator Wy 14,643. Mutat. Res., 286: 123-133, 1993.
28. Elliot, B. M., Dodd, N. J. R., and Elcombe, C. R. Increased hydroxyl radical production in liver peroxisomal fraction from rats treated with peroxisome proliferators. Carcinogenesis (Lond.), 7: 195-199, 1986.
29. Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., and Green, S. The mouse peroxisome proliferator-activaled receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11: 433-439, 1992.
30. Lock, E. A., Mitchell, A. M., and Elcombe, C. R. Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol., 29: 145-163, 1989.
31. Lalwani, N. D., Reddy, M. K., Qureshi, S. A., Sirtori, C. R., Abiko, Y., and Reddy, J. K. Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver. Hum. Toxicol., 2: 27-48, 1983.
32. Hertz, R., and Bar-TANA, J. Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes. Biochem. J., 281: 41-43, 1992.
33. Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., and Evans, R. M. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature (Lond.), 345: 224-229, 1990.
34. Gray, T. J. B., Lake, B. G., Beamand, J. A., Foster, J. R., and Gangolli, S. D. Peroxisome proliferation in primary cultures of rat hepatocytes. Toxicol. Appl. Pharmacol., 67: 15-25, 1983.
35. Oesch, F., and Schladt, L. Coordinate induction of peroxisomal β-oxidation activity and cytosolic epoxide hydrolase activity. Pharmacoi. & Ther., 33: 29-35, 1987.
36. Schladt, L., Hartmann, R., Timms, C., Strolin-Benedetti, M., Dosert, P., Worner, W., and Oesch, F. Concomitant induction of cytosolic but not microsomal epoxide hydrolase with peroxisomal β-oxidation by various hypolipidemic compounds. Biochem. Pharmacol., 36: 345-351, 1987.
37. Pahan, K., Gulati, S., and Singh, I. Phytanic acid α-oxidation in rat liver mitochondria. Biochim. Biophys. Acta. 1201: 491-497, 1994.
38. Kawashima, Y., Nakagawa, S., Tachibana, Y., and Kosuka, H. Effects of peroxisome proliferators on fatty acid-binding protein in rat liver. Biochim. Biophys. Acta, 754: 21-27, 1983.
39. Anderson, N. L., Esquer-Blasco, R., Richardson, F., Foxworthy, P., and Eacho, P. The effects of peroxisome proliferators on protein abundances in mouse liver. Toxicol. Appl. Pharmacol., 137: 75-89, 1996,
40. Lillehaug, J. R., and Berge, R. K. The tumour promoter 12-O-tetradecanoylphorbol-13-acetate increases the activities of some peroxisome-associated enzymes in in vitro cell culture. Br J. Cancer, 53: 121-127, 1986.
41. Bronfman, M., Orellana, A., Morales, M. N., Biere, F., Waechter, F., Staubli, W., and Bentley, P. Potentiation of diacylglycerol-activated protein kinase C by acyl-coenzyme A thioesters of hypolipidemic drugs. Biochem. Biophys. Res. Commun., 159: 1026-1031, 1989.
42. Mikalsen, S. O., Ruyter, B., and Sanner, T. Effects of hepatic peroxisome proliferators and 12-O-tetradecanoylphorbol-13-acetate on catalase and other enzyme activities of embryonic cells in vitro. Biochem. Pharmacol., 39: 527-535, 1990.