The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

Genes and Development

Volumn 17, Issue 5, 2003, Pages 586-590

  Pant, Vinod ^a   Mariano, Piero ^a   Kanduri, Chandrasekhar ^a   Mattsson, Anita ^a   Lobanenkov, Victor ^b   Heuchel, Rainer ^c   Ohlsson, Rolf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Chromatin insulator; CTCF; DNA methylation; Genomic imprinting; Igf2

Indexed keywords

CTCF PROTEIN; NUCLEOTIDE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CHROMATIN; DNA METHYLATION; GENE; GENE CONTROL; GENE REPRESSION; GERM LINE; H19 GENE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ANIMALS; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENOMIC IMPRINTING; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; REPRESSOR PROTEINS; RNA, UNTRANSLATED; TRANSCRIPTION FACTORS;

EID: 0037338544     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.254903     Document Type: Article

References (26)

1. Bartolomei, M.S. and Tilghman, S.M. 1997. Genomic imprinting in mammals. Annu. Rev. Genet. 31: 493-525.
2. Bell, A.C. and Felsenfeld, G. 2000. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature 405: 482-485
3. Bell, A.C., West, A.G., and Felsenfeld, G. 2001. Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome. Science 291: 447-450.
4. Dean, W., Bowden, L., Aitchison, A., Klose, J., Meneses, J., Reik, W., and Feil, R. 1998. Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: Association with abberant phenotypes. Development 125: 2273-2282.
5. Forne, T., Oswald, J., Dean, W., Saam, J., Bailleul, B., Dandolo, L., Tilghman, S., Walter, J., and Reik, W. 1997. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans. Proc. Natl. Acad. Sci. 94: 10243-10248.
6. Hark, A.T., Schoenherr, C.J., Katz, D.J., Ingram, R.S., Levorse, J.M., and Tilghman, S.M. 2000. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405: 486-489.
7. Holmgren, C., Kanduri, K., Dell, G., Ward, A., Mukhopadhya, R., Kanduri, M., Lobanenkov, V., and Ohlsson, R. 2001. CpG methylation regulates the Igf2/H19 insulator. Curr. Biol. 11: 1128-1130.
8. Hori, N., Nakano, H., Takeuchi, T., Kato, H., Hamaguchi, S., Oshimura, M., and Sato, K. 2002. A dyad Oct binding sequence functions as a maintenance sequence for the unmethylated state within the H19/ Igf2-imprinted control region. J. Biol. Chem. 277: 27960-27967.
9. Horsthemke, B., Surani, M.A., James, T.C., and Ohlsson, R. 1999. The mechanisms of genomic imprinting. In Genomic imprinting: An interdisciplinary approach (ed. R. Ohlsson), pp. 91-118. Springer-Verlag, Berlin.
10. Kaffer, C.R., Srivastava, M., Park, K.Y., Ives, E., Hsieh, S., Batlle, J., Grinberg, A., Huang, S.P., and Pfeifer, K. 2000. A transcriptional insulator at the imprinted H19/Igf2 locus. Genes & Dev. 14: 1908-1919.
11. Kanduri, C., Holmgren, C., Franklin, G., Pilartz, M., Ullerås, E., Kanduri, M., Liu, L., Ginjala, V., Ulleras, E., Mattsson, R., et al. 2000a. The 5′-flank of the murine H19 gene in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication. Curr. Biol. 10: 449-457.
12. Kanduri, C., Pant, V., Loukinov, D., Pugacheva, E., Qi, C.-F., Wolffe, A., Ohlsson, R., and Lobanenkov, A. 2000b. Functional interaction of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr. Biol. 10: 853-856.
13. Kanduri, M., Kanduri, C., Mariano, P., Vostrov, A., Quitsche, W., Lobanenkov, V., and Ohlsson, R. 2002. Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Mol. Cell. Biol. 22: 3339-3344.
14. Kuo, M. and Allis, C. 1999. In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment. Methods 19: 425-433.
15. LaSalle, J.M. and Lalande, M. 1996. Homologous association of oppositely imprinted chromosomal domains. Science 272: 725-728.
16. Lewandoski, M. and Martin, G. 1997. Cre-mediated chromosome loss in mice. Nat. Genet. 17: 223-225.
17. Liang, L., Kanduri, C., Pilartz, M., Svensson, K., Song, J., Wentzel, P., Eriksson, U., and Ohlsson, R. 2000. Dynamic readjustment of parental methylation patterns of the 5′-flank of the mouse H19 gene during in vitro organogenesis. Int. J. Dev. Biol. 44: 785-790.
18. Loukinov, D., Pugacheva, E., Vatolin, S., Pack, S., Moon, H., Chernukhin, I., Mannan, P., Larsson, E., Kanduri, C., Vostrov, A., et al. 2002. BORIS, a novel male germline-specific protein associated with epigenetic reprogramming events, shares the same 11 Zn-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc. Natl. Acad. Sci. 99: 6806-6811.
19. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., and Roder, J. 1993. Derivation of completely culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. 90: 8424-8428.
20. Ohlsson, R., Renkawitz, R., and Lobanenkov, V. 2001. CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet. 17: 520-527.
21. Olek, A. and Walter, J. 1997. The pre-implantation ontogeny of the H19. methylation imprint. Nat. Genet. 17:275-276.
22. Olek, A., Oswald, J., and Walter, J. 1996. A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res. 24: 5064-5066.
23. Sasaki, H., Ferguson-Smith, A., Shum, A., Barton, S., and Surani, M. 1995. Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos. Development 121: 4195-4202.
24. Shemer, R., Hershko, A., Perk, J., Mostoslavsky, R., Tsubert, B.-Z., Cedar, H., Buiting, K. and Razin, A. 2000. The imprinting box of the Prader-Will/Angelman syndrome domain. Nat. Genet. 26: 440-443.
25. Szabó, P., Tang, S.-H., Rentsendorj, A., Pfeifer, G., and Mann, J. 2000. Maternal-specific footprints at putative CTCF sites in the H19 imprinting control region give evidence for insulator function. Curr. Biol. 10: 607-610.
26. Tremblay, K., Duran, K., and Bartolomei, M.S. 1997. A 5′ 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol. Cell. Biol. 17: 4322-4329.