The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication

Current Biology

Volumn 10, Issue 8, 2000, Pages 449-457

  Kanduri, C ^a   Holmgren, C ^a   Pilartz, M ^a,b   Franklin, G ^a   Kanduri, M ^a   Liu, L ^a   Ginjala, V ^a   Ulleras E ^a   Mattsson, R ^a   Ohlsson, R ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0034177668     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00442-5     Document Type: Article

References (26)

1. Dao D., Frank D., Qian N., O'Keefe D., Vosatka R., Walsh C.et al. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. Hum Mol Genet. 7:1998;597-608.
2. Bartolomei M.S., Tilghman S.M. Genomic imprinting in mammals. Annu Rev Genet. 31:1997;493-525.
3. Thorvaldsen J.L., Duran K.L., Bartolomei M.S. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 12:1998;3693-3702.
4. Olek A., Walter J. The pre-implantation ontogeny of the H19 methylation imprint. Nat Genet. 17:1997;275-276.
5. Elson D., Bartolomei M. A 5′ differentially methylated sequence and the 3′-flanking region are necessary for H19 transgene imprinting. Mol Cell Biol. 17:1997;309-317.
6. Leighton P., Ingram R., Eggenschwiler J., Efstratiadis A., Tilghman S. Disruption of imprinting caused by deletion of the H19 region in mice. Nature. 375:1995;34-39.
7. Lyko F., Brenton J.D., Surani M.A., Paro R. An imprinting element from the mouse H19 locus functions as a silencer in Drosophila. Nat Genet. 16:1997;171-173.
8. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 1998, 19:187-191.
9. Nan X., Ng H.-H., Johnson C., Laherty C.D., Turner B.M., Eisenman R.N.et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 393:1998;386-389.
10. Svensson K., Mattsson R., James T., Wentzel P., Pilartz M., MacLaughlin J.et al. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. Development. 125:1998;61-69.
11. Leighton P.A., Ingram R.S., Eggenschwiler J., Efstratiadis A., Tilghman S.M. Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature. 375:1995;34-39.
12. Banerjee S., Smallwood A. A chromatin model of IGF2/H19 imprinting. Nat Genet. 11:1995;237-238.
13. Webber A., Ingram R., Levorse J., Tilghman S. Location of enhancers is essential for the imprinting of H19 and Igf2 genes. Nature. 391:1998;711-715.
14. Geramisova T., Corces V. Ohlsson R. Genomic Imprinting: An Interdisciplinary Approach, vol 25. 1999;229-249 Springer-Verlag, Berlin.
15. Leighton P., Saam J., Ingram R., Stewart C., Tilghman S. An enhancer deletion affects both H19 and Igf2 expression. Genes Dev. 9:1995;2079-2089.
16. Hark A.T., Tilghman S.M. Chromatin conformation of the H19 epigenetic mark. Hum Mol Genet. 7:1998;1979-1985.
17. Khosla S., Aitchison A., Gregory R., Allen N.D., Feil R. Parental allele-specific chromatin configuration in a boundary/imprinting-control element upstream of the mouse H19 gene. Mol Cell Biol. 19:1999;2556-2566.
18. Stadnick M.P., Pieracci F.M., Cranston M.J., Taksel E., Thorvaldsen J.L., Bartolomei M.S. Role of a 461-bp G-rich repetitive element in H19 transgene imprinting. Dev Genes Evol. 19:1999;239-248.
19. Chung J.H., Bell A.C., Felsenfeld G. Characterization of the chicken β-globin insulator. Proc Natl Acad Sci USA. 21:1997;575-580.
20. Banerjee S., Singh P., Rasberry C., Cattanach B. Embryonic inheritance of the chromatin organisation of the imprinted H19 domain in mouse spermatozoa. Mech Dev. 90:2000;217-226.
21. Bulger M., Groudine M. Looping versus linking. toward a model for long-distance gene regulation Genes Dev. 13:1999;2465-2477.
22. Yoo-Warren H., Pachnis V., Ingram R., Tilghman S. Two regulatory domains flank the mouse H19 gene. Mol Cell Biol. 8:1988;4707-4715.
23. Franklin G.C., Adam G.I., Miller S.J., Moncrieff C.L., Ulleras E., Ohlsson R. An Inr-containing sequence flanking the TATA box of the human c-sis (PDGF-B) proto-oncogene promoter functions in cis as a co-activator for its intronic enhancer. Oncogene. 11:1995;1873-1884.
24. Hao Y., Crenshaw T., Moulton T., Newcomb E., Tycko B. Tumour-suppressor activity of H19 RNA. Nature. 365:1993;764-767.
25. Sasaki H., Jones P., Chaillet J., Ferguson-Smith A., Barton S., Reik W.et al. Parental, imprinting. potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene Genes Dev. 6:1992;1843-1856.
26. Walsh C., Glaser A., Fundele R., Ferguson-Smith A., Barton S., Surani M.A.et al. The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes. Mech Dev. 46:1994;55-62.