Antisense candidates against protein kinase C-α designed based on phylogenesis and simulant structure of mRNA

Acta Pharmacologica Sinica

Volumn 24, Issue 3, 2003, Pages 269-276

  Song, Hai Feng ^a   Tang, Zhong Ming ^a   Yuan, Shou Jun ^a   Zhu, Bao Zhen ^a   Liu, Xiu Wen ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Antisense oligodeoxynucleotides; Drug design; Phylogeny; Protein kinase C

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; PROTEIN KINASE C ALPHA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DESIGN; GENE TARGETING; GENETIC ANALYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHYLOGENY; PROTEIN SECONDARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA STRUCTURE; TARGET CELL; TUMOR GROWTH; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE, TUMOR; COMPUTER-AIDED DESIGN; DRUG DESIGN; HUMANS; ISOENZYMES; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, SECONDARY; RATS; RNA, MESSENGER;

EID: 0037334886     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Branch AD. A good antisense molecule is hard to find. Trends Biochem Sci 1998; 23: 45-50.
2. Perry CM, Balfour JA. Fomivirsen. Drugs 1999; 57: 375-80.
3. Eckstein F. Searching for the ideal partner. Nat Biotechnol 1998; 16: 24-4.
4. Monia BP, Johnston JF, Geiger T, Muller M, Fabbro D. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nature med 1996; 2: 668-75.
5. Ziegler A, Luedke GH, Fabbro D, Altmann KH, Stahel RA, Zangemeister-Wittke U. Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the bcl-2 coding sequence. J Natl Cancer Inst 1997; 89: 1027-36.
6. Hannaert V, Opperdoes FR, Michels PA. Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different kinetoplastida. J Mol Evol 1998; 47: 728-38.
7. Coy JF, Sedlacek Z, Bachner D, Delius H, Poustka A. A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3′-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression. Hum Mol Genet 1999; 8: 1253-62.
8. Song HF, Tang ZM, Yuan SJ, Zhu BZ. Application of secondary structure prediction in antisense drug design targeting protein kinase C-α mRNA and QSAR analysis. Acta Pharmacol Sin 2000; 21: 80-6.
9. Dean N, Mckay R, Miraglia L, Howard R, Cooper S, Giddings J, et al. Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res 1996; 56: 3499-507.
10. Mcgraw K, Mckay R, Miraglia L, Boggs RT, Pribble JP, Muller M, et al. Antisense oligonucleotide inhibitors of isozymes of protein kinase C: in vitro and in vivo activity, and clinical development as anti-cancer therapeutics. Anti Cancer Drug Design 1997; 12: 315-26.
11. Turner DH, Sugimoto N, Freier SM. RNA structure prediction. Annu Rev Biophys Biophys Chem 1988; 17: 167-92.
12. Dean NM, Mckay R, Condon TP, Bennett CF. Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J Biol Chem 1994; 269: 16416-24.
13. Elias JM. Nonradioactive in situ hybridization for viral detection. In: Elias JM, editor. Immunohistopathology. Chicago: ASPC Press; 1990. p 404-40.
14. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86: 9717-21.
15. Denham DW, Franz MG, Denham W, Zervos EE, Gower WR Jr, Rosemurgy AS, et al. Directed antisense therapy confirms the role of protein kinase C-α in the tumorigenicity of pancreatic cancer. Surgery 1998; 124: 218-24.
16. Swiderski CE, Klei TR, Horohov DW. Quantitative measurement of equine cytokine mRNA expression by polymerase chain reaction using target-specific standard curves. J Immunol Methods 1999; 222: 155-69.
17. Agrawal S, Jiang Z, Zhao Q, Shaw D, Cai Q, Roskey A, et al. Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies. Proc Natl Acad Sci USA 1997; 94: 2620-5.
18. Temsamani J, Guinot P. Antisense oligonucleotides: a new therapeutic approach. Biotechnol Appl Biochem 1997; 26: 65-71.