Application of secondary structure prediction in antisense drug design targeting protein kinase C-α mRNA and QSAR analysis

Acta Pharmacologica Sinica

Volumn 21, Issue 1, 2000, Pages 80-86

  Song, Hai Feng ^a   Tang, Zhong Ming ^a   Yuan, Shou Jun ^a   Zhu, Bao Zhen ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Antisense oligodeoxyribonucleotides; Drag design; Protein kinase C; Secondary protein structure; Structure activity relationship

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ISIS 3521; MESSENGER RNA; PROTEIN KINASE C;

ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN SECONDARY STRUCTURE; PROTEIN TARGETING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL DIVISION; COMPUTER-AIDED DESIGN; DRUG DESIGN; ISOENZYMES; LUNG NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, SECONDARY; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0033977659     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

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