Neural pathways between sacrocaudal afferents and lumbar pattern generators in neonatal rats

Journal of Neurophysiology

Volumn 89, Issue 2, 2003, Pages 773-784

  Strauss, I ^a   Lev Tov, A ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; LOCOMOTION; LUMBAR SPINE; NERVE PROJECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SACRAL SPINAL CORD; SENSORY NERVE; SYNAPTIC TRANSMISSION; THORACOLUMBAR SPINE;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ADRENERGIC ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; LUMBAR VERTEBRAE; NEURONS, AFFERENT; PERIODICITY; PRAZOSIN; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SACRUM; SPINAL CORD; SYNAPTIC TRANSMISSION; YOHIMBINE;

EID: 0037321235     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00716.2002     Document Type: Article

References (48)

1. Baldissera F, Hultborn H, and Illert M. Integration in spinal neuronal systems. In: Handbook of Physiology, edited by Brooks VB. Bethesda, MD: American Physiology Society, 1981, p. 509-595.
2. Ballion B, Morin D, and Viala D. Forelimb locomotor generators and quadrupedal locomotion in the neonatal rat. Eur J Neurosci 14: 1727-1738. 2001.
3. Baranauskas G and Nistri A. Membrane potential oscillations of neonatal rat spinal motoneurons evoked by electrical stimulation of dorsal root fibres. Eur J Neurosci 7: 2403-2408, 1995.
4. Bennett DJ, Gorassini M, Fouad K, Sanelli L, Han Y, and Cheng J. Spasticity in rats with sacral spinal cord injury. J Neurotrauma 16: 69-84, 1999.
5. Bonnot A, Whelan PJ, Mentis GZ, and O'Donovan MJ. Spatiotemporal pattern of motoneuron activation in the rostral lumbar and the sacral segments during locomotor-like activity in the neonatal mouse spinal cord. J Neurosci 22: 1-6, 2002.
6. Brustein E and Rossignol S. Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. I. Deficits and adaptive mechanisms. J Neurophysiol 80: 1245-1267, 1998.
7. Cazalets JR and Bertrand S. Coupling between lumbar and sacral motor networks in the neonatal rat spinal cord. Eur J Neurosci 12: 2993-3002, 2000.
8. Cazalets JR, Sqalli Houssaini Y, and Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol 455: 187-204, 1992.
9. Cowley KC and Schmidt BJ. Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord. J Neurophysiol 77: 247-259, 1997.
10. Delvolvé I, Gabbay H, and Lev-Tov A. The motor output and behavior produced by rhythmogenic sacrocaudal networks in spinal cords of neonatal rats. J Neurophysiol 85: 2100-2110, 2001.
11. Gabbay H, Delvolvé I, and Lev-Tov A. Pattern generation in caudal-lumbar and sacrococcygeal segments of the neonatal rat spinal cord. J Neurophysiol 88: 732-739, 2002.
12. Giesler GJ Jr, Spiel HR, and Willis WD. Organization of spinothalamic tract axons within the rat spinal cord. J Comp Neurol 195: 243-252, 1981.
13. Gimenez y Ribotta M, Provencher J, Feraboli-Lohnherr D, Rossignol S, Privat A, and Orsal D. Activation of locomotion in adult chronic spinal rats is achieved by transplantation of embryonic raphe cells reinnervating a precise lumbar level. J Neurosci 20: 5144-5152, 2000.
14. Grillner S and Zangger P. On the central generation of locomotion in the low spinal cat. Exp. Brain Res 34: 241-261, 1979.
15. Grossman ML, Basbaum AI, and Fields HL. Afferent and efferent connections of the rat tail flick reflex (a model used to analyze pain control mechanisms). J Comp Neurol 206: 9-16, 1982.
16. Grottel K, Bukowska D, Huber J, and Celichowski J. Distribution of the sacral neurones of origin of the ascending spinal tracts with axons passing through the lateral funiculi of the lowermost thoracic segments: an experimental HRP study in the cat. Neurosci Res 34: 67-72, 1999.
17. Jordan LM. Brainstem and spinal cord mechanisms for the initiation of locomotion. In: Neurobiological Basis of Human Locomotion, edited by Shimamura M, Grillner S, and Edgerton VR. Tokyo: Japan Scientific Societies Press, 1991, p. 3-21.
18. Kerr FW. The ventral spinothalamic tract and other ascending systems of the ventral funiculus of the spinal cord. J Comp Neurol 159: 335-356, 1975.
19. Kiehn O and Kjaerulff O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J Neurophysiol 75:1472-1482, 1996.
20. Kjaerulff O and Kiehn O. Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J Neurosci 16: 5777-5794, 1996.
21. Kremer E and Lev-Tov A. Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J Neurophysiol 77: 1155-1170, 1997.
22. Krutki P, Mrowczynski W, and Grottel K. Lamina VII and VIII neurons of the S2 segment bilaterally projecting to the C6 segment of the spinal cord in the cat. J Physiol 91: 325-330, 1997.
23. Kudo N and Yamada T. N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro. Neurosci Lett 75: 43-48, 1987.
24. Lev-Tov A and Delvolvé I. Pattern generation in non-limb moving segments of the mammalian spinal cord. Brain Res Bull 53: 671-675, 2000.
25. Lev-Tov A, Delvolvé I, and Kremer E. Sacrocaudal afferents induce rhythmic efferent bursting in isolated spinal cords of neonatal rats. J Neurophysiol 83: 888-894, 2000.
26. Loy DN, Magnuson DS, Zhang YP, Onifer SM, Mills MD, Cao QL, Darnall JB, Fajardo LC, Burke DA, and Whittemore SR. Functional redundancy of ventral spinal locomotor pathways. J Neurosci 22: 315-323, 2002.
27. Magnuson DS and Trinder TC. Locomotor rhythm evoked by ventrolateral funiculus stimulation in the neonatal rat spinal cord in vitro. J Neurophysiol 77: 200-206, 1997.
28. Marchetti C, Beato M, and Nistri A. Alternating rhythmic activity induced by dorsal root stimulation in the neonatal rat spinal cord in vitro. J Physiol 530: 105-112, 2001.
29. Matsushita M. Ascending propriospinal afferents to area X (substantia grisea centralis) of the spinal cord in the rat. Exp Brain Res 119: 356-366, 1998.
30. McClellan AD. Descending control and sensory gating of 'fictive' swimming and turning responses elicited in an in vitro preparation of the lamprey brainstem/spinal cord. Brain Res 302: 151-162, 1984.
31. Miller WL and Sigvardt K. A spectral analysis of oscillatory neural circuits. J Neurosci Methods 80: 113-128, 1998.
32. Molenaar I and Kuypers HG. Cells of origin of propriospinal fibers and of fibers ascending to supraspinal levels. A HRP study in cat and rhesus monkey. Brain Res 152: 429-450, 1978.
33. Molenaar I, Rustioni A, and Kuypers HG. The location of cells of origin of the fibers in the ventral and the lateral funiculus of the cat's lumbo-sacral cord. Brain Res 78: 239-254, 1974.
34. Noga BR, Kriellaars DJ, and Jordan LM. The effect of selective brainstem or spinal cord lesions on treadmill locomotion evoked by stimulation of the mesencephalic or pontomedullary locomotor regions. J Neurosci 11: 1691-1700, 1991.
35. Pearson KG and Rossignol S. Fictive motor patterns in chronic spinal cats. J Neurophysiol 66: 1874-1887, 1991.
36. Pinco M and Lev-Tov A. Synaptic transmission between ventrolateral funiculus axons and lumbar motoneurons in the isolated spinal cord of the neonatal rat. J Neurophysiol 72: 2406-2419, 1994.
37. Rossignol S. Neural control of stereotypic limb movements. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems, edited by Rowel LB and Sheperd JT. Bethesda, MD: American. Physiology Society, 1996, p. 173-216.
38. Smith JC, Feldman JL, and Schmidt BJ. Neural mechanisms generating locomotion studied in mammalian brain stem-spinal cord in vitro. FASEB J 2: 2283-2288, 1988.
39. Soffe SR. Triggering and gating of motor responses by sensory stimulation: behavioural selection in Xenopus embryos. Proc R Soc Lond B Biol Sci 246: 197-203, 1991.
40. Steeves JD and Jordan LM. Localization of a descending pathway in the spinal cord which is necessary for controlled treadmill locomotion. Neurosci Lett 20: 283-288, 1980.
41. Stokke MF, Nissen UV, Glover JC, and Kiehn O. Projection patterns of commissural interneurons in the lumbar spinal cord of the neonatal rat. J Comp. Neurol 446: 349-359, 2002.
42. Tresch MC and Kiehn O. Coding of locomotor phase in populations of neurons in rostral and caudal segments of the neonatal rat lumbar spinal cord. J Neurophysiol 82: 3563-3574, 1999.
43. Wada N and Shikaki N. Neuronal pathways for spinal reflexes activated by group I and group II muscle afferents in the spinal segment (Col) innervating the tail in the low spinalized cat. Exp Brain Res 125: 129-138, 1999.
44. Walker C, Vierck CJJ, and Ritz LA. Balance in the cat: role of the tail and effects of sacrocaudal transection. Behav Brain Res 91: 41-47, 1998.
45. Whelan PJ. Control of locomotion in the decerebrate cat. Prog Neurobiol 49: 481-515, 1996.
46. Whelan PJ, Bonnot A, and O'Donovan MJ. Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse. J Neurophysiol 84: 2821-2833, 2000.
47. Yakovenko S, Mushahwar V, VanderHorst V, Holstege G, and Prochazka A. Spatiotemporal activation of lumbosacral motoneurons in the locomotor step cycle. J Neurophysiol 87: 1542-1553, 2002.
48. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice Hall, 1984.