Coding of locomotor phase in populations of neurons in rostral and caudal segments of the neonatal rat lumbar spinal cord

Journal of Neurophysiology

Volumn 82, Issue 6, 1999, Pages 3563-3574

  Tresch, Matthew C ^a   Kiehn, Ole ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; INTERNEURON; LOCOMOTION; LUMBAR SPINAL CORD; MOTONEURON; NERVE CELL; NEUROMODULATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; VOLUNTARY MOVEMENT;

EID: 0033396063     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.82.6.3563     Document Type: Article

References (45)

1. ARSHAVSKY, I., GELFAND, I. M., ORLOVSKY, G. N., PAVLOVA, G. A., AND POPOVA, L. B. Origin of signals conveyed by the ventral spino-cerebellar tract and spino-reticulo-cerebellar pathway. Exp. Brain Res. 54: 426-431, 1984.
2. BATSCHELET, E. Circular Statistics in Biology. New York: Academic, 1981.
3. BERKINBLIT, M. B., DELIAGINA, T. G., FELDMAN, A. G., GELFAND, I. M., AND ORLOVSKY, G. N. Generation of scratching. I. Activity of spinal interneurons during scratching. J. Neurophysiol. 41: 1040-1057, 1978.
4. BERKOWITZ, A. AND STEIN, P.S.G. Activity of descending propriospinal axons in the turtle hindlimb enlargement during two forms of fictive scratching: broad tuning to regions of the body surface. J. Neurosci. 14: 5089-5104, 1994a.
5. BERKOWITZ, A. AND STEIN, P.S.G. Activity of descending propriospinal axons in the turtle hindlimb enlargement during two forms of fictive scratching: phase analyses. J. Neurosci. 14: 5105-5119, 1994b.
6. BRACCI, E., BALLERINI, L., AND NISTRI, A. Localization of rhythmogenic networks responsible for spontaneous bursts induced by strychnine and bicuculline in the rat isolated spinal cord. J. Neurosci. 16: 7063-7076, 1996.
7. CAZALETS J. R., BORDE M., AND CLARAC F. Localization and organization of the central pattern generator for hindlimb locomotion in newborn rat. J. Neurosci. 15: 4943-4951, 1995.
8. CHENG J., STEIN R. B., JOVANOVIC K., YOSHIDA K., BENNETT D. J., AND HAN Y. Identification, localization, and modulation of neural networks for walking in the mudpuppy (Necturus maculatus) spinal cord. J. Neurosci. 18: 4295-4304, 1998.
9. COWLEY, K. C. AND SCHMIDT, B. J. Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord. J. Neurophysiol. 77: 247-259, 1997.
10. DELIAGINA, T. G., ORLOVSKY, G. N., AND PAVLOVA, G. A. The capacity for generation of rhythmic oscillations is distributed in the lumbosacral spinal cord of the cat. Exp. Brain Res. 53: 81-90, 1983.
11. DREW, T. AND DOUCET, S. Application of circular statistics to the study of neuronal discharge during locomotion. J. Neurosci. Methods 38: 171-181, 1991.
12. EIDE, A.-L., GLOVER, J., KJAERULFF, O., AND KIEHN, O. Characterization of commissural interneurons in the lummbar region of the neonatal rat. J. Comp. Neurol. 403: 332-345, 1999.
13. FETZ, E. E. Cortical mechanisms controlling limb movement. Curr. Opin. Neurobiol. 3: 932-939, 1993.
14. GEORGOPOULOS, A. P., KETTNER, R. E., AND SCHWARTZ, A. B. Primate motor cortex and free arm movements to visual targets in three-dimensional space. II. Coding of the direction of movement by a neuronal population. J. Neurosci. 8: 2928-2937, 1988.
15. GOSSARD, J. P., BROWNSTONE, R. M., BARAJON, I., AND HULTBORN, H. Transmission in a locomotor-related group Ib pathway from hindlimb extensor muscles in the cat. Exp. Brain Res. 98: 213-228, 1984.
16. GRAY, C. M., MALDONADO, P. E., WILSON, M., AND MCNAUGHTON, B. Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex. J. Neurosci. Methods 63: 43-54, 1995.
17. HO, S. AND O'DONOVAN, M. J. Regionalization and intersegmental coordination of rhythm-generating networks in the spinal cord of the chick embryo. J. Neurosci. 13: 1354-1371, 1993.
18. HOCHMAN, S., JORDAN, L. M., AND MACDONALD, J. F. N-methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord. J. Neurophysiol. 72: 2559-2562, 1994.
19. HOCHMAN, S. AND SCHMIDT, B. J. Whole cell recordings of lumbar motoneurons during locomotor-like activity in the in vitro neonatal rat spinal cord. J. Neurophysiol. 79: 743-752, 1998.
20. IIZUKA, M., KIEHN, O., AND KUDO, N. Development in neonatal rats of the sensory resetting of the locomotor rhythm induced by NMDA and 5-HT. Exp. Brain Res. 114: 193-204, 1997.
21. JANKOWSKA, E. Interneuronal relay in spinal pathways from proprioceptors. Prog. Neurobiol. 38: 335-378, 1992.
22. KALASKA, J. F. AND CRAMMOND, D. J. Cerebral cortical mechanisms of reaching movements. Science 255: 1517-1523, 1992.
23. KIEHN, O., JOHNSON, B. R., AND RAASTAD, M. Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity. Neuroscience 75: 263-273, 1996.
24. KIEHN, O. AND KJAERULFF, O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J. Neurophysiol. 75: 1472-1482, 1996.
25. KIEHN, O. AND KJAERULFF, O. Distribution of central pattern generators for rhythmic motor outputs in the spinal cord of limbed vertebrates. In: Neuronal Mechanisms for Generating Locomotor Activity, edited by O. Kiehn, R. M. Harris-Warrick, L. M. Jordan, H. Hultborn, and N. Kudo. New York: Ann. NY Acad. Sci., 1998, vol. 860, p. 110-130.
26. KJAERULFF, O. AND KIEHN, O. Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J. Neurosci. 16: 5777-5794, 1996.
27. KJAERULFF, O. AND KIEHN, O. Crossed rhythmic synaptic input to motoneurons during selective activation of the contralateral spinal locomotor network. J. Neurosci. 17: 9433-9447, 1997.
28. KREMER, E. AND LEV-TOV, A. Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J. Neurophysiol. 77: 1155-1170, 1997.
29. LEWIS, J. E. AND KRISTAN, W. B. Representation of touch location by a population of leech sensory neurons. J. Neurophysiol. 80: 2584-2592, 1998.
30. MACLEAN, J. N., HOCHMAN, S., AND MAGNUSON, D. S. Lamina VII neurons are rhythmically active during locomotor-like activity in the neonatal rat spinal cord. Neurosci. Lett. 197: 9-12, 1995.
31. MARDIA, K. Statistics of Directional Data. New York: Academic, 1972.
32. MORTIN, L. I. AND STEIN, P.S.G. Spinal cord segments containing key elements of the central pattern generators for three forms of scratch reflex in the turtle. J. Neurosci. 9: 2285-2296, 1989.
33. NICOLOPOLOUS-STOURNARS, S. AND ILES, J. F. Motoneuron columns in the lumbar spinal cord of the rat. J. Comp. Neurol. 217: 75-85, 1983.
34. PUSKAR, Z. AND ANTAL, M. Localization of last-order premotor interneurons in the lumbar spinal cord of rats. J. Comp. Neurol. 389: 377-389, 1997.
35. RAASTAD, M., JOHNSON, B. R., AND KIEHN, O. The number of postsynaptic currents necessary to produce locomotor-related cyclic information in neurons in the neonatal rat spinal cord. Neuron 17: 729-738, 1996.
36. RAASTAD, M. AND KIEHN, O. Spike coding during locomotor rhythm in ventrally located neurons in the isolated spinal cord from neonatal rat. J. Neurophysiol. In press.
37. 4 spinal segment of the cat during brainstem-evoked fictive locomotion. Exp. Brain. Res. 80: 290-295, 1990.
38. SQALLI-HOUSSAINI, Y., CAZALETS, J. R., AND CLARAC, F. Oscillatory properties of the central pattern generator for locomotion in neonatal rats. J. Neurophysiol. 70: 803-813, 1993.
39. 5 interneurons of the neonatal rat spinal cord. 57th Scandinavian Physiological Congress, Lund, Sweden, 1998a.
40. TRESCH, M. C. AND KIEHN, O. Comparison of locomotor related activity in L2 and L5 interneurons of the neonatal rat spinal cord. Peripheral and Spinal Mechanisms in the Neural Control of Movement, Tuscan, AZ, 1998b.
41. VIALA, D., VIALA, G., AND JORDAN. M. Interneurones of the lumbar cord related to spontaneous locomotor activity in the rabbit. I. Rhythmically active interneurones. Exp. Brain Res. 84: 177-186, 1991.
42. WESTBERG, K., CLAVELOU, P., SANDSTROM, G., AND LUND, J. P. Evidence that trigeminal brainstem interneurons form subpopulations to produce different forms of mastication in the rabbit. J. Neurosci. 18: 6466-6479, 1998.
43. WHEATLEY, M., JOVANOVIC, K., STEIN, R. B., AND LAWSON, V. The activity of interneurons during locomotion in the in vitro necturus spinal cord. J. Neurophysiol. 71: 2025-2032, 1994.
44. WILSON, M. A. AND MCNAUGHTON, B. L. Dynamics of the hippocampal ensemble code for space. Science 261: 1055-1058, 1993.
45. YOSHIDA, M., ROBERTS, A., AND SOFFE, S. R. Axon projections of reciprocal inhibitory interneurons in the spinal cord of young Xenopus tadpoles and implications for the pattern of inhibition during swimming and struggling. J. Comp. Neurol. 400: 504-518, 1998.