Current treatment of severely burned patients

Annals of Surgery

Volumn 223, Issue 1, 1996, Pages 14-25

  Nguyen, Thuan T ^a   Gilpin, David A ^a   Meyer, Nicholas A ^a   Herndon, David N ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PROPRANOLOL;

ARACHIDONIC ACID METABOLISM; BURN; DIAGNOSTIC APPROACH ROUTE; DISEASE SEVERITY; EXCISION; HEMODYNAMICS; HUMAN; IMMUNE FUNCTION TEST; NUTRITIONAL SUPPORT; PATIENT COMPLIANCE; PRIORITY JOURNAL; RESUSCITATION; RETROSPECTIVE STUDY; REVIEW; SEPSIS; WOUND CLOSURE; WOUND HEALING;

BURNS; DEBRIDEMENT; FLUID THERAPY; HUMANS; INFLAMMATION MEDIATORS; MULTIPLE ORGAN FAILURE; RESUSCITATION; SEPSIS; SHOCK; SMOKE INHALATION INJURY; THROMBOXANES; WOUND HEALING;

EID: 0030031897     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199601000-00004     Document Type: Review

References (122)

1. Bull JP, Fisher AJ. A study of mortality in a burns unit: a revised estimate. Ann Surg 1954; 139:269-274.
2. Muller MJ, Herndon DN. The challenges of burns. Lancet 1994; 343:216-220.
3. Phillips AW, Cope O. Burn therapy II: the revelation of respiratory tract damage as a principal killer of the burned patient. Ann Surg 1962; 155:1-10.
4. Herndon DN, Curreri RW, Abston S, et al. Treatment of burns. Curr Probl Surg 1987; 2:347-373.
5. Brown JM. Respiratory complications in burned patients. Physiotherapy 1977; 63:151-153.
6. Clark WR Jr., Webb WR, Wax S, Nieman G. Inhalation injuries: the pathophysiology of acute smoke inhalation. Surg Forum 1977; 28:177-178.
7. Nguyen TT, Cox CS, Traber DL, et al. Free radical activity and loss of plasma antioxidants, vitamin E, and sulfhydryl groups in patients with burn. J Burn Care Rehabil 1993; 14:602-609.
8. Drost AC, Burleson DG, Cioffi WG, et al. Plasma cytokines following thermal injury and their relationship with patient mortality, burn size, and time postburn. J Trauma 1993; 35:335-339.
9. Harms B, Bodai B, Demling R. Prostaglandin release and altered microvascular integrity after burn injury. J Surg Res 1981; 31:274-280.
10. Robson M, Del Beccraro E, Heggers J. Increased dermal perfusion after burning by decreasing thromboxane production. J Trauma 1980; 20:722-726.
11. Anggard E, Jonsson CE. Efflux of prostaglandins in lymph from scalded tissue. Acta Physiol Scand 1971; 81:440-443.
12. Herndon DN, Abston S, Stein MD. Increased thromboxane B2 levels in the plasma of burned and septic burned patients. Surg Gynecol Obstet 1984; 159:210-213.
13. Arturson G. Anti-inflammatory drugs and burn edema formation. In May R, Dogo G, eds. Care of the burn wound. Karger: Basel, 1981.
14. Arturson G, Hamberg M, Jonsson CE. Prostaglandins in human burn blister fluid. Acta Physiol Scand 1973; 87:270-276.
15. LaLonde C, Knox J, Daryani R, Zhu D, Demling RH, Neumann M. Topical flurbiprofen decreases burn wound-induced hypermetabolism and systemic lipid peroxidation. Surgery 1991; 109:645-651.
16. Heggers JP, Loy GL, Robson MC, Del Beccaro EJ. Histological demonstration of prostaglandins and thromboxanes in burned tissue. J Surg Res 1980; 28:110-115.
17. Heggers JP, Robson MC, Zachary LS. Thromboxane inhibitors for the prevention of progressive dermal ischemia due to thermal injury. J Burn Care Rehabil 1985; 6:466-468.
18. Huang YS, Li A, Yang ZC. Roles of thromboxane and its inhibitor anisodamine in burn shock. Burns 1990; 4:249-253.
19. Demling RH, LaLonde C. Topical ibuprofen decreases early postburn edema. Surgery 1987; 5:857-861.
20. LaLonde C, Demling RH. Inhibition of thromboxane synthetase accentuates hemodynamic instability and burn edema in the anesthetized sheep model. Surgery 1989; 5:638-644.
21. Baxter CR, Shires GT. Physiologic response to crystalloid resuscitation of severe burns. Ann NY Acad Sci 1968; 150:874-893.
22. Pruitt BA. Fluid resuscitation for extensively burned patients. J Trauma 1981; 21:690-692.
23. Carvajal HF. A physiologic approach to fluid therapy in severely burned children. Surg Gynecol Obstet 1980; 150:379-385.
24. Monafo WW. The treatment of burn shock by the intravenous and oral administration of hypertonic lactated saline solution. J Trauma 1970; 10:575-586.
25. Morris SE, Navaratnam N, Townsend CM, Herndon DN. Decreased mesenteric blood flow independently promotes bacterial translocation in chronically instrumented sheep. Surg Forum 1989; 40:88-90.
26. Tokyay R, Traber DL, Herndon. Thromboxane synthetase inhibition prevents the increased mesenteric vascular resistance seen after major burn in a chronic porcine model. Surg Forum 1990; 41:47-49.
27. Tokyay R, Loick HM, Traber DL, et al. Effects of thromboxane synthetase inhibition on postburn mesenteric vascular resistance and the rate of bacterial translocation in a chronic porcine model. Surg Gynecol Obstet 1992; 174:125-132.
28. Herndon DN, Ziegler ST. Bacterial translocation after thermal injury. Crit Care Med 1993; 21(2):S50-S54.
29. Fox JCL, Rappole BW, Stanford W. Control of pseudomonas infection in burns by silver sulfadiazine. Surg Gynecol Obstet 1969; 128:1201-1205.
30. Moncrief JA, Lindberg RB, Switzer WE, et al. Use of topical antimicrobial therapy in the treatment of the burn wound. Arch Surg 1966; 62:812-816.
31. Moyer CA, Breutaush G, Gravens T, et at. Treatment of large human burns with 0.5% silver nitrate solution. Arch Surg 1956; 90:812-816.
32. Desai MH, Herndon DN. Eradication of Candida burn wound septicemia in massively burned patients. J Trauma 1988; 28(2):140-145.
33. Desai MH, Rutan RL, Heggers JP, Herndon DN. Candida infection with and without nystatin prophylaxis: a 11-year experience with patients with burn injury. Arch Surg 1992; 127:159-162.
34. Robson MC, Krizek TS. Predicting skin graft survival. J Trauma 1973; 13(3):213-217.
35. Waymack JP, Pruitt BA. Burn wound infection. In: Advances in Surgery. St. Louis: Mosby Year Book, 1990, pp 261-289.
36. Dacso CC, Luterman A, Curreri PW. Systemic antibiotic treatment in burned patients. Surg Clin N Am 1987; 67(1):57-67.
37. Pruitt BA, O'Neill JA, Moncrief JA, Lindberg RB. Successful control of burn-wound sepsis. JAMA 1968; 203(12):150-152.
38. Monafo WW, West M. Current treatment recommendations for topical burn treatment. Drugs 1990; 40(3):364-373.
39. Moncrief JA, Lindberg RB, Switzer WE, Pruitt BA. Use of topical therapy in the treatment of the burn wound. Arch Surg 1966; 92:558-565.
40. Pruitt BA, Foley FD. The use of biopsies in burn patient care. Surg 1973; 73(6):887-897.
41. Barbour A, Alfred C, Selber C, et al. Chemiluminescence by polymorphonuclear leukocytes from patients with active bacterial infection. J Infect Dis 1980; 141(1):14-26.
42. Burleson DG, Mason AD Jr., Pruitt BA Jr. Lymphoid subpopulation changes after thermal injury and thermal injury with infection in an experimental model. Ann Surg 1988; 207(2):208-212.
43. Hansbrough JF, Gadd MA. Temporal analysis of murine lymphocyte subpopulations by monoclonal antibodies and dual color flow cytometry after burn and non-burn injury. Surg 1989; 106(1):69-80.
44. Bjerknes R, Bindenes H, Laerum OP. Altered neutrophil functions in patients with large burns. Blood Cells 1990; 17(5):402-405.
45. Hasslen SR, Nelson RD, Kishimoto TK, et al. Down regulation of homing receptors: a mechanism for impaired recruitment of human phagocytes in sepsis. J Trauma 1991; 31(5):645-651.
46. Ogle JD, Noel JG, Sramkoski RM, et al. Effect of antibiotics on CR1 receptor levels on human neutrophils and on the binding and phagocytosis of opsonized polystyrene microspheres by these leukocytes. Burns 1989; 15(3):141-144.
47. Dunn SM, Hillam AJ, Stomski F, et al. Leukocyte adhesion molecules involved in inflammation. Transpl Proc 1989; 21(1):31-34.
48. Mileski W, Borgstrom D, Lightfoot E, et al. Inhibition of leukocyte endothelial adhesion following thermal injury. J Surg Res 1992; 52:334-339.
49. Warden GD, Mason AD Jr., Pruitt Ba Jr. Evaluation of leukocyte chemotaxis in vitro in thermally injured patients. J Clin Invest 1974; 54(5):1001-1004.
50. Warden GD, Mason AD Jr., Pruitt BA Jr. Suppression of leukocyte chemotaxis in vitro by chemotherapeutic agents used in the management of thermal injuries. Ann Surg 1975; 181(3):363-369.
51. Altman LC, Klebanoff SJ, Curreri PW. Abnormalities of monocyte chemotaxis following thermal injury. J Surg Res 1977; 22(6):616-620.
52. Fikrig SM, Karl SC, Suntharalingam K. Neutrophil chemotaxis in patients with burns. Ann Surg 1977; 186(6):746-748.
53. Majeski JA, McClellan MA, Alexander JW. Evaluation of leukocyte chemotactic response in the presence of antibiotics. Surg Forum 1975; 26:83-85.
54. Cole WQ, Cook JJ, Grogan JB. In vitro neutrophil function and lysosomal enzyme levels in patients with sepsis. Surg Forum 1975; 26:79-81.
55. Curreri PW, Heck EL, Browne L, Baxter CR. Stimulated nitroblue tetrazolium test to assess neutrophil antibacterial function: prediction of wound sepsis in burned patients. Surg 1973; 74(1):6-13.
56. Heck EL, Browne L, Curreri PW, Baxter CR. Evaluation of leukocyte function in burned individuals by in vitro oxygen consumption. J Trauma 1975; 15(6):486-489.
57. Singh H, Abdullah A, Herndon DN. Effects of rat interleukin-2 and rat interferon on the natural killer cell activity of rat spleen cells after thermal injury. J Burn Care Rehabil 1992; 13:617-622.
58. Cuthbertson DP. Observations on the disturbances of metabolism produced by injury to the limbs. Q J Medicine 1932 233-246.
59. Lieberman ZH, Lansche JM. Effects of thermal injury on metabolic rate and insensible water loss in the rat. Surg Forum 1957; 7:83.
60. Caldwell FT Jr. The effect of early eschar excision upon the nutritional state and rate of wound closure of rats with full-thickness thermal burns. Surgery 1961; 49:454-460.
61. Caldwell FT, Osterhoz M, Sower ND, Moyer CA. Metabolic response to thermal trauma of normal and thyroprivic rats at three environmental temperatures. Ann Surg 1959; 150:976-988.
62. Caldwell FT Jr., Levitsky K. Nitrogen balance after thermal burns: Effect of early eschar excision. Arch Surg 1963; 86:500-503.
63. Caldwell FT, Hammel HT, Lolan F. A calorimeter for simultaneous determination of heat production and heat loss in the rat. J Appl Physiol 1966; 21:1665-1671.
64. Rutan TC, Herndon DN, Osten TV, Abston S. Metabolic rate alterations in early excision and grafting versus conservative treatment. J Trauma 1986; 26(2):140-142.
65. Wilmore DW, Long JM, Mason AD Jr., et al. Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg 1974; 180:653-669.
66. Gilpin DA, Herndon DN. The acute metabolic response to skin injury following burns and the potential use of growth hormone. New York: Springer-Verlag/Year Book, in press.
67. Wilmore DW, Long JM, Mason AD Jr., Pruitt BA Jr. Stress in surgical patients as a neurophysiologic response. Surg Gynecol Obstet 1976; 142:257-263.
68. Bessey PQ, Watters JM, Aoki TT, Wilmore DW. Combined hormonal infusion simulates the metabolic response to injury. Ann Surg 1984; 200:264-269.
69. Hildreth MA, Herndon DN, Desai MH, Duke MA. Caloric needs of adolescent patients with burns. J Burn Care Rehab 1989; 10(6):523-526.
70. Hildreth MA, Herndon DN, Desai MH, Broemeling LD. Current treatment reduces calories required to maintain weight in pediatric patients with burns. J Burn Care Rehab 1990; 11(5):405-409.
71. Gilpin DA, Muller MJ, Herndon DN. Enhancing wound helaing in severely burned children. In: Wilmore DW, Carpentier YA, eds. Metabolic Support of the Critically Ill Patient. Series: Update in Intensive Care and Emergency Medicine. New York: Springer-Verlag, 1993.
72. Linares HA. A report of 115 consecutive autopsies in burned children, 1966-1980. Burns 1982; 8:263-270.
73. Joshi W. Effects of burns on the heart. JAMA 1970; 211(13):2130-2134.
74. Lilyedahl SO, Gemzell CA, Plastin LO, Burke G. Effect of human growth hormone in patients with severe burns. Acta Chir Scand 1961; 122:1-14.
75. Wilmore DW, Moyln JA, Bristow BF, et al. Anabolic effects of human growth hormone and high caloric feeding following thermal injury. Surg Gynaecol Obstet 1974:138:875-884.
76. Soroff HS, Pearson E, Green NL, Artz CP. The effect of growth hormone on nitrogen balance at various levels of intake in burned patients. Surg Gynaecol Obstet 1960; 111:259-273.
77. Jiang ZM, He GZ, Zhang SY, et al. Low dose growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major operation. Ann Surg 1989; 210:513-525.
78. Ziegle TR, Young RD, McManson J, Wilmore DW. Metabolic effects of recombinant growth hormone in patients receiving parenteral nutrition. Ann Surg 1988; 208:6-16.
79. Daughaday WH. The anterior pituitary. In: Wilson JD, Foster DW, eds. William's Textbook of Endocrinology, 7th ed. Philadelphia: Saunders, 1985, pp 598-602.
80. Strock LL, Singh H, Abdullah A, et al. The effect of insulin-like growth factor I on postburn hypermetabolism. Surgery 1990; 108:161-164.
81. Kupfer SR, Underwood LE, Baxter RC, et al. Enhancement of the anabolic effects of growth hormone and insulin like growth factor 1 by use of both agents simultaneously. J Clin Invest 1993; 91:391-396.
82. Herndon DN, Barrow RE, Rutan TC, et al. Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients. Ann Surg 1988; 208(4):484-492.
83. Maggi SP, Biolo G, Muller MJ, et al. Beta-1 blockade decreases cardiac work without affecting protein breakdown or lipolysis in severely burned patients. Surg Forum 1993; 75:1081.
84. Hollyoak MA, Meyer NA, Muller MJ, et al. Clenbuterol, an anabolic agent, does not further impair wound healing in burned rats. Proc Am Burn Assoc 1994; 26:84.
85. Janzekovic Z. A new concept in the early excision and immediate grafting of burns. J Trauma 1975; 15:42-62.
86. Burke JF, Bandoc CC, Quinby WC. Primary burn excision and immediate grafting: a method for shortening illness. J Trauma 1974; 14:389-395.
87. Herndon DN, Barrow RE, Rutan RL, et al. A comparison of conservative versus early excision: therapies in severely burned patients. Ann Surg 1989; 209(5):547-553.
88. Desai MH, Herndon DN, Broemeling LD, et al. Early burn wound excision significantly reduces blood loss. Ann Surg 1990; 211(6):753-762.
89. Desai MH, Rutan RL, Herndon DN. Conservative treatment of scald burns is superior to early excision. J Burn Care Rehab 1991; 12:482-484.
90. Alexander JW, MacMillan BF, Law E, et al. Treatment of burn with widely meshed skin autograft and meshed skin allograft overlay. J Trauma 1981; 21:433-438.
91. Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg 1991; 8(4):937-953.
92. Brown GL, Nanney LB, Griffen J, et al. Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 1989; 321(2):76-79.
93. Gabrilove JL, Schwartz A, Chrug J. Effects of hormones on the skin in endocrinological disorders. J Clin Endocrinol Metab 1962; 22:688-692.
94. Jorgenson PH, Andreassen TT, Jorgensen KD. Growth hormone influences collagen deposition and mechanical strength of intact rat skin: a dose response study. Acta Endocrinol 1989; 120:767-772.
95. Jorgenson PH, Andreassen TT. A dose response study of the effects of biosynthetic growth hormone on formation and strength of granulation tissue. Endocrinology 1987; 121:1637-1641.
96. Jorgenson PH, Andreassen TT. The influence of biosynthetic human growth hormone on biomechanical properties and collagen formation in granulation tissue. Horm Metab Res 1988; 20:490-493.
97. Herndon DN, Barrow RE, Kunkel KR, et al. Effects of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg 1990; 212:424-431.
98. Gilpin DA, Barrow RE, Rutan RL, et al. Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Ann Surg 1994; 220:19-24.
99. Gore DC, Honeycutt D, Jahoor F, et al. Effect of exogenous growth hormone on whole-body and isolated-limb protein kinetics in burned patients. Arch Surg 1991; 126:38-43.
100. Rutan RL, Broemeling DL, Barrow RE, Herndon DN. Cost effectiveness of rh growth hormone therapy in pediatric patients. Proc Am Burn Assoc 1994; 26:89.
101. Heimbach D, Luterman A, Burke J, et al. Artificial dermis for major burns. Ann Surg 1988; 208:313-320.
102. Yannas IV, Burke JF. Design of an artificial skin. I. Basic design principles. J Biomed Mater Res 1980; 14:65-81.
103. Yannas IV, Burke JF, Gordon PL. Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res 1980; 14:107-131.
104. Yannas IV, Burke JF, Warpehoski M. Design principles and preliminary clinical performance of an artificial skin. In Cooper SL, Peppas NA, eds. Advances in Chemistry Series, No. 199. Biomaterials: Interfacial Phenomena and Applications. Washington, DC: American Chemistry Society, 1982, pp 475-481.
105. O'Connor NE, Mulliken JB, Banks-Schiegel S, et al. Grafting of burns with cultured epithelium prepared from autologous epidermal cells. Lancet 1981; 1:75-78.
106. Desai MH, Mlakar JM, McCauley RL, et al. Lack of long-term durability of cultured keratinocyte burn-wound coverage: a case report. J Burn Care Rehabil 1991; 12:540-545.
107. Heimbach DM. A nonuser's questions about cultured epidermal autograft. J Burn Care Rehabil 1992; 13:127-129.
108. James MI. The effect of synthetic dressings on wound contraction. Master's thesis, 1992, University of Edinburgh.
109. Williams WG, Perez-Polo JR, Robson MC, et al. Recovery of functional sensation in full-thickness and partial-thickness skin grafts in the rat. Proc Am Burn Assoc 1994; 26:16.
110. Deitch EA, Wheelahan TM, Rose MP, et al. Hypertrophic burn scars: analysis of variables. J Trauma 1983; 23:895-898.
111. Larson DL, Evans EB, Abston S, et al. Techniques for decreasing scar formation and scar contractures in the burn patient. J Trauma 1971; 11:807-823.
112. Herndon DN, Traber DL, Niehaus GD, et al. The pathophysiology of smoke inhalation injury in a sheep model. J Trauma 1984; 24(12):1044-1051.
113. Linares HA, Herndon DN, Traber DL. Sequence of morphologic events in experimental smoke inhalation. J Burn Care Rehabil 1989; 10(1):27-37.
114. Stein MD, Herndon DN, Stevens JM, Traber LD, Traber DL. Production of chemotactic factors and lung cell changes following smoke inhalation in a sheep model. J Burn Care Rehabil 1986; 7(2):117-121.
115. Bland RD, Kim MH, Light MJ, et al. High frequency mechanical ventilation in severe hyaline membrane disease. Crit Care Med 1980; 8:275-280.
116. Brichant JF, Rouby JJ, Viars P. Intermittent positive pressure ventilation with either positive end expiratory pressure or high frequency jet ventilation (HFJV), or HFJV alone in human acute respiratory failure. Anesth Analg 1986; 65:1135-1142.
117. Butler WJ, Bohn DJ, Bryan AC, et al. Ventilation by high frequency oscillation in humans. Anesth Analg 1980; 59:577-584.
118. El-Baz N, Faber LP, Doolas A. Combined high frequency ventilation for management of terminal respiratory failure: a new technique. Anesth Analg 1983; 62:39-49.
119. Freitag L, Long WM, Kim CS, Wanner A. Removal of excessive bronchial secretions by asymmetric high-frequency oscillations. J Appl Physiol 1989; 67(2):614-619.
120. Cioffi WG Jr., Rue LW, Graves TA, et al. Prophylactic use of high-frequency percussive ventilation in patients with inhalation injury. Ann Surg 1991;213(6):575-582.
121. Herndon DN, Traber DL, Traber LD. The effect of resuscitation on inhalation injury. Surg 1986; 100(2):248-251.
122. Niehaus GD, Kimura R, Traber LD, et al. Administration of a synthetic antiprotease reduces smoke-induced lung injury. J Appl Physiol 1990; 69(2):694-699.