Pharmacology and molecular action of retinoids and vitamin D in skin

Journal of Investigative Dermatology Symposium Proceedings

Volumn 1, Issue 1, 1996, Pages 15-21

  Kang, Sewon ^a   Li, Xiao Yan ^a   Voorhees, John J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

L.zsdihy droxyvitamin d; Metabolism; P 450; Retinoic acid

Indexed keywords

CALCITRIOL; CALCITRIOL RECEPTOR; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; RETINOL; TRANSCRIPTION FACTOR; VITAMIN D;

ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SKIN;

ANIMALS; CALCITRIOL; HUMANS; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS; SKIN; TRANSCRIPTION FACTORS; VITAMIN A; VITAMIN D;

EID: 0030112279     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (108)

1. McCollum EV, Davis M: The necessity of certain lipids in the diet during growth.JEW Chcm 15:167-175, 1913
2. Osbome TB, Mendel LB: The relation of growth to the chemical constituents of the diet. J Biol Chcm 15:311-326. 1913
3. Tobin CJ: Retinoids, homeoboxes and growth factors toward molecular models for limb development. Cell 66:199-217, 1991
4. Mellanby T: The part played by an "accessory factor" in the production of experimental rickets. J Physiol 52:11-12, 1918
5. McCollum EV, Simmonds N, Becker JE, Shipley PG: Studies on experimental rickets: an experimental demonstration of the existence of a vitamin \vhich promotes calcium deposition. J Biol Client 53:293-312, 1922
6. Saurat JH: Side effects of systemic retinoids and their clinical management. J Am Acad Dermatol 17:S23-S28, 1992
7. Lambert WE, Meyer E, DeLeeheer AP, De Bersaques J, Kint AH: Pharmacokinetics and drug interactions of etretinate and acitretin.J Am AcaJ Dermatol 27:S19-S22, 1992
8. Fritsch PO: Retinoids in Psoriasis and disorders of keratinization. J Am AcaJ Dermatol 27:S8-S14, 1992
9. Kragballe K: Vitamin D3 and skin diseases. Arch Dermatol Res 284:S30-S36, 1992
10. Forman BM, Samuels HH: Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Enâocrinol 4:1293-1301, 1990
11. Green S, Wahli W: Peroxisome proliferator activated receptors: finding the orphan a home. Mol Cell EnJocriiwl 100:149-153, 1994
12. Umesono K, Murakami KK, Thompson CC, Evans RM. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-1266, 1991
13. Yu VC, Delsert C, Andersen B, HollowayJM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Roscnfeld MG: RXR: a co-regulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response element. Cell 67:1251-1266, 1991
14. Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker \V: Two nuclear signaling pathways for vitamin D. Nature 361:657-660,1993
15. Green S: Nuclear honnone receptors-promiscuous liaisons. Nature 361:590591, 1993
16. Fawell SE, Lees JA, White R, Parker MG: Characterization and colocalizaton of steroid binding and dimerization activities in the mouse estrogen receptor. Cell 60:953-962, 1990
17. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P: Functional domains of the human estrogen receptor. Cell 51:941-951, 1987
18. Webster NJG, Green S, Jin JR, Chambon P: The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199-207, 1988
19. Webster NJG, Green S, Tasset D, Ponglikitmongkol M, Chambon P: The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J 8:1441-1446, 1989
20. Picard D, Yamamoto KR: Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBOJ 6:3333-3340, 1987
21. \VaId G: The molecular basis of visual excitation. Mature 219:819-822, 1968
22. Buck J, Derguini F, Lcvi E, Nakamiski K, Hammerling U: Intracellular signaling by 14-hydroxy 4,14-rctrorccinol. Science 254:1654-1656, 1991
23. Eppinger TM, Buck J, Hammerling U: Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells. J Exp Mcd 178:1995-2005, 1993
24. Hofmann C, Eichelc G: Rerinoids in development. In: Spom MB, Roberts AB, Goodman DS (eds.): The Rctinoids: Biology Chemistry and Medicine 2nd ed. Raven Press, New York, 1994, pp. 387-441
25. Blomhoff R, Green MH, Norum K: Vitamin A: physiological and biochemical processing. Anna Rev Nittr 12:37-57, 1992
26. Levin MS, Li W, Onf DE, Gordon JI: Comparison of the tissue specific expression and developmental regulation of two closely linked parent genes encoding cytosolic retinol-binding proteins. J Biol Chein 262:7118-7124, 1987
27. Herr F, Ong DE: Differential interaction of lecithin-retinol acyltransferase with cellular retinoid-bindîng proteins. Biochemistry 31:6748-6755, 1992
28. Boerman MHEM, Napoli JL: Cholate-indepcndcnt rctinyl ester hydrolysis. J Biol Chan 263:22273-22278, 1991
29. Fisher GJ, Reddy AP, Datta SC, Kang S, Yi JY, Chambon P, Voorhees JJ: All-trans retinoic acid and all-trans retinol induce cellular retinol-binding protein in human skin in-vivo. J Invest Dermatol 105:80-86, 1995
30. Kurlandsky SB, Xiao JH, Duell EA, Voorhees JJ, Fisher GJ: Biological activity of all-trans retinol requires metabolic conversion to all-trans retinoic acid and is mediated through activation of nuclear retinoid receptors in human keratinocytes.J Biol Chem 269:32821-32827, 1994
31. Ong DE, Chytil F: Cellular retinoic acid-binding protein from rat tcstis. J Biol Chem 253:4551-4554, 1978
32. Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner CM, Gudas LJ, Chambon P: Differential expression of genes encoding a, and y retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature 342:702-705, 1989
33. Gigucrc V, Lyii S, Yip P, Siu CH, Amin S: Molecular cloning of cDNA encoding a second cellular rctinoic acid-binding protein. Proc NatI Acad Sci USA 87:6233-6237, 1990
34. Boylan JF, Gudas LJ: Overexpression of the cellular retinoic acid binding protein-1 (CRABP-1) results in reduction in differentiation-specific gene expression in F9 teratocarcinoma cells. J Cell Biol 112:965-979, 1991
35. Fiorella PD, Napoli JL: Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in rctinoic acid metabolism.J Biol Chem 266:16572-16579, 1991
36. Boylan JF, Gudas LJ: The level of CPvABP-1 expression influences the amounts and types of all-trans retinoic acid metabolites in F9 teratocarcinoma stem cells.} Biol Chem 267:21486-21491, 1992
37. Lampron C, Rochette-Egly C, Gorry P, Dolle P, Mark M, Lufkin T, LcMcur M, Chambon P: Mice deficient in cellular retinoic acid binding protein II (CRABP-II) or in both CRABP-I and CRABP-II are essentially normal. Deivhpmetit 121:539-548, 1995
38. Allenby G, Bocquel M-T, Saunders M, Kazmer S, Speck J, Roscnberger M, Lovcy A, Kastner P, Grippo JF, Chambon P, Levin AA: Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 90:30-34, 1993
39. Urbach J, Rando R: Isomerization of all-trans retinoic acid to 9-fis rctinoic acid. BiochemJ 299:459-465, 1994
40. Duell EA, Aström A, Griffiths CEM, Chambon P, Voorhees JJ: Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxy-retinoic acid after topical application of retinoic acid in vivo compared to concentration required to stimulate retinoic acid receptor-mediated transcription in vitro. J Clin Invest 90:1269-1274, 1992
41. Petkovich M, Brand NJ, Krust A, Chambon P: A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330:444-450, 1987
42. Giguere V, Ong ES, Segui P, Evans RM: Identification of a receptor for the morphogen retinoic acid. Nature 330:624-629, 1987
43. Mangelsdorf DJ, Ong ES, Dycfc JA, Evans RM: Nuclear receptor that identifies a novel retinoic acid-responsive pathway. Nature 345:224-229, 1990
44. Levin AA, Sturzcnbeckcr LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Roscnbergcr M, Lovey A, Grippo JF. 9-m-retinoic acid stcroisomer binds and activates the nuclear receptor POCRa. Nature 355:359-361, 1992
45. Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichelc G, Evans RM, Thaller C: 9-fij-retinoic acid is a high-affinity ligand for the retinoid X receptor. Cell 68:397-406, 1992
46. Kastner P, Krust A, Mcndchohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P: Murine isofonns of retinoic acid receptor gamma with specific patterns of expression. Proc Natl Acad Sci U S A 87:2700-2704, 1990
47. Giguere V, Shago M, Zirngibl R, Täte P, Rossant J, Varmuza S: Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. Mol Cell Biol 10:2335-2340, 1990
48. Zclcnt A, Mendclsohn C, Kastncr P, Krust A, Gamier JM, Ruffenach F, Leroy P, Chambon P: Differentially expressed isofonns of the mouse retinoic acid receptor are generated by usage of two promoters and alternative splicing. EMBOJ 10:71-81, 1991
49. Mangelsdorf DJ, Borgmcycr U, Hcyman RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM: Characterization of three P^XR genes that mediate the action of 9-os rctinoic acid. Genes Dcv 6:329-344, 1991
50. Rowe A, Eager NSC, Brickell PM: A member of the POCR nuclear receptor family is expressed in neural-crest-derived cells of the developing chick peripheral nervous system. Development 111:771-778, 1991
51. Fisher GJ, Talwar US. XiaoJH, Datta SC, Reddy AP, Gaub MP. Rochette-Egly C, Chambon P, Voorhees JJ: Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Citent 269:20629-20635, 1994
52. Elder JT, Fisher GJ, Zhang QY, Eisen D, Krust P, Chambon Pt Voorhees JJ: Rerinoic acid receptor gene expression in human skin. J Invest Dcnnatol 96:425-433, 1991
53. Tavakkol A, Griffiths GEM, Keane KM, Palmer RD, Voorhees JJ: Cellular localization of mRNA for cellular retinoic acid-binding protein II and nuclear retinoic acid receptor-gamma 1 in retinoic acid-treated human skin. J Invest Dennatol 99:146-150. 1992
54. Elder JT, Aström A, Pettersson U, Tavakkol A, Griffiths CEM, Krust A, Kastner P, Chambon P, Voorhees JJ: Differential regulation of retinoic acid receptors arid binding proteins in human skin. J Invest Dennatol 98:673-679, 1992
55. Herrlich P, Ponta H: Mutual cross-modulation of steroid/retinoic acid receptor and AP-1 transcription factor activities: a novel property with practical implications. Trends Endocrinol Metab 5:341-346, 1994
56. Saatcioglu F, Claret F-X, Karin M: Negative transcription al regulation by nuclear receptors. Scmin Cancer Biol 5:347-359, 1994
57. Angel P, Karin M: The role of Jun, Fos and AP-1 complex in cell proliferation and transformation. Biochem Biophys Acta 1072:129-157, 1991
58. Nagpal S, Athanikar J, Chandraratna RAS: Separation of transactivation and AP-1 functions of retinoic acid receptor a.J Biol Chem 270:923-927, 1995
59. Fanjul A, Dawson MI, Hobbs PD, Jong L, CameronJF, Harlev E, Graupner G, Lu X-P, Pfahl M: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372:107-110, 1994
60. Aström A, Pcttcrson U, Chambon P, Voorhees JJ: Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing. J Biol Chem 269:22334-22339, 1994
61. Smith \VC, Nakashatri H, Leroy P, Rces J, Chambon P: A retinoic acid response element is present in the mouse cellular retinol binding protein I (m CRBP I) promoter. EMBOJ 10:2223-2230, 1991
62. SniadeckiJ: Cited by W. Mozolowski. Jerdrzej Snaidecki (1768-1883) on the cure of rickets. Nature 143:121, 1939
63. Hess AF, Linger LF: Cure of infantile rickets by sunlight.J Am Med Assoc 77:39, 1921
64. MaycrJ: Armand Trousseau and the arrow of time. Nutr Rev 15:321-322, 1957
65. Holick MF: Photobiology, physiology and clinical applications for vitamin D. In: Goldsmith LA (ed.). Physiology, Biochemistry, and Molecular Biology of the Skin. 2nd éd.. Vol 1. Oxford University, New York, 1991, p 928
66. Holick MF, MacLaughlîn JA, Doppelt SH: Factors that influence the cutaneous photosynthesis of previtamin D3. Scietice 211:590-593, 1981
67. Webb AR, deCosta BR, Holick MF: Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegredation. J Clin Endocrinol Metab 68:882-887, 1989
68. Boyle IT, Miravet L, Gray RW, Holick MF, DeLuca HF: The response of intestinal calcium transport to 25-hydroxy and 1,25-diliydroxyvitamin D in nephrectomized rats. Endocrinology 90:605-608, 1972
69. Holick MF, Garabedian M, DeLuca HF: 1,25-Dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats. Science 176:1146-1147, 1972
70. Fraser DR, Kooh SW, Kind HP, Holick MF, Tanaka Y, DcLuca HF: Pathogenesis of hereditary vitamin D dependent rickets: an inborn error of vitamin D metabolism involving defective conversion of 25-dihydroxyvitamin D to la,25-dihydroxyvitamin D. N Engl J Med 289:817-822, 1973
71. Portale AA, Halloran BP, Murphy MM, Morris RC Jr: Oral intake of phosphorus can determine the scrum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans. J Clin Invest 77:7-12, 1986
72. Igbal SJ: Vitamin D metabolism and the clinical aspects of measuring metabolites. Ann Clin Biochem 31:109-124. 1994
73. Gray TK, Lowe W, Lester GE: Vitamin D and pregnancy: the maternal foetal metabolism of vitamin D. EnJocr Rev 2:264-274, 1981
74. Adams J, Diz MM, Gacad MA: Regulated expression of sarcoid macrophage 25 hydroxyvitamin D 1-hydroxyvitamin D I-hydroxylation reaction. In: Norman AW, Schaefer K, Grigoleit HGG, Herrath DV (eds.). Vitamin D Molecular, Cellular and Clinical Endocrinology. Walter de Gruyter, Berlin, 1988, pp 855-856
75. Bickle DD. Nemanic MK, Whitncy JO. Elias PW: Neonatal human foreskin keratinocytes produce 1,25 dihydroxyvitamin D3. Biochemistry 25:1545-1548, 1986
76. Howard GA, Turner RT, Sherrard DJ, Baylink DJ: Human bone cells in culture metabolize 25 hydroxyvitamin D to 1,25 dihydroxy and 24,25 dihydroxyvitamin D3. J Biol Chem 256:7738-7740, 1981
77. Corvol M, Ulman A, Garabedian M: Specific nuclear uptake of 24,25 dihydroxycholecalciferol, a vitamin D3 metabolite active in cartilage. FEBS Lett 116:273-276, 1980
78. Kraft O, Offermann G, Steldinger R. Gawlic D: Effect of 1,25(OH)2D3 or 24,25(OH)2D3 on experimental rickets. Res Commun Chem Pathol Pharmacol 26:571-583, 1979
79. Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF: Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary gland and parathyroid. Science 206:1188-1190, 1979
80. Raichel H, Koefler MD, Norman AW: The role of vitamin D endocrine system in health and disease. N Enj/J Med 320:980-991. 1989
81. Holick MF, Smith E, Pincus S: Skin as the site of vitamin D synthesis and target tissue for 1,25 dihydroxyvitamin D,. Arch Dermatol 123:1676-1683, 1987
82. Smith EL, Walworth ND, Holick MF: Effect of 1,25 dihydroxyvitamin D3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J Invest Denitatol 86:709-714, 1986
83. Colston K, Colston MJ, Feldman D: 1,25-dihydroxyvitamin Dj and malignant melanoma: the presence of receptors and inhibitions of cell growth in culture. Endocrinology 108:1083-1086, 1981
84. Tanaka H, Abe E, Miyaura C: 1,25-Dihydroxycholeciferol and human myeloid leukemia cell line (HL-60): the presence of cytosol receptor and induction of differentiation. BixhemJ 204:713-719, 1982
85. Morimoto S, Kumahara Y: A patient with psoriasis cured by 1 or-hydroxyvitamin D3. MeJJ Osaka Univ 35:51-54, 1985
86. Jones G, Calverly MJ: A dialogue on analogues: newer vitamin-D drugs for use in bone disease, psoriasis and cancer. Trenils Endocrinol Metab 4:297-303, 1993
87. Haussler MR, Norman AW: Chromasomal receptor for a vitamin D metabolite. Proc Nail Acad Sci U S A 62:155-162, 1969
88. Kream BG, Reynolds RD, Knutson JC, Eisman JA, DeLuca HF: Intestinal cytosol binders of 1,25-hydroxyvitamin D3 and 25-dihydroxyvitamin D3. Arch Bioehem Biophys 176:779-787, 1976
89. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, Pike JW, Shine J, O'Mallcy BW: Cloning and expression of full-length c-DNA encoding human vitamin D receptor. Proc Nail Acad Sci V S A 85:3294-3298, 1988
90. Bunncstcr JK, Maeda N, DeLuca HF: Isolation and expression of rat 1,25dihydroxyvitamin D3 receptor cDNA. Proc Nail Acad Sci U S A 85:10051009, 1988
91. Hughes MR, Malloy PJ, Kieback DG, Kestcrson RA, Pike JW, Feldman D, O'Malley BW: Point mutations in human vitamin D receptor gene associated with hypocalcémie rickets. Science 242:1702-1705, 1988
92. Dame MC, Pierce EA, DeLuca HF: Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotring. Proc Nail Acad Sci USA 82:7825-7829, 1985
93. Ross TK, Darwish HM, DeLuca HF: Molecular biology of vitamin D action. In: Vitamins and Hormones. Vol. 49. Academic Press, San Diego, CA, 1994, pp 281-326
94. Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF: Cellular and subcellular localization of l,25(OH)2-vitarmn Dj in rat kidney; comparison with localization of parathyroid hormone and estradiol. Proc Natl Acad Sci USA 77:1149-1153, 1980
95. Walters MR, Hunziker W, Norman AW: Unoccupied 1,25-dihydroxyvitamin D3 receptors: nuclear/cytosol ratio depends on ionic strength. J Biol Client 255:6799-6805, 1980
96. BarsonyJ, Pike J\V, DeLuca HF, Marx SJ: Immunocytology with microwavefixed fibroblasts shows 1 a,25-dihydroxyvitamin D3-dependent rapid and estrogen-dependent slow reorganization of vitamin D receptors. J Cell Biol 111:2385-2395, 1990
97. Krishnan AV, Feldman D: Cyclic adcnosine 3',5'-monophosphate upregulate 1,25-dihydroxyvitamin D3 receptor gene expression and enhances hormone action. Mol EnJocrinol 6:198-206, 1992
98. van Leeuwen JPTM, Birkenhager JC, Wijngaarden TVV, van den Bernd GJCM, Pols HAP: Regulation of 1,25-dihydroxyvitamïn D3 receptor gene expression by parathyroid hormone and cAMP-agonists. Biochem Biophfs Res Commun 185:881-886, 1992
99. Krishnan AV, Feldman D: Stimulation of l,25-dihydroxy\Titamin D3 receptor gene expression in cultured cells by serum and growth factors. J Bunt Miner Res 6:1099-1107, 1991
100. Massaro ER, Simpson RU, DeLuca HF: Glucocorricoids and appearance of l,25(OH)2Dj receptor in rat intestine. AmJ Physio] 2-t4:E230-E235, 1983
101. Petkovich PM, Heersche JNM, Tinker DO, Jones G: Retinoic acid stimulates 1,25-dihydroxyvitamin D3 binding in rat osteosarcoma cells. J Biol Client 259:8274-8290, 1984
102. Pols HAP, van Leeuwen JPTM, Schilte JP, Visser TJ, Birkenhager JC: Heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone and PTH-like peptide in osteoblast-Iike cells. Biochem Biofltf Res Commun 156:588-594, 1988
103. Arbour NC, Prahl JM, DeLuca HF: Stabilization of the vitamin D receptor in rat osteosarcoma cells through the action of 1,25-dihydroxyvitamin D3. Mol Endocrinol 7:1307-1312, 1993
104. Santiso-Mere D, Sone T, Hilliard GM, IV, Pike J\V. McDonnell DP: Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. Mol Endocrinol 7:833-839, 1993
105. Wiese RJA, Ross TK, Prahl JM, DeLuca HF: Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligandinduced stabilization. J Biol Client 267:20082-20086, 1992
106. Morrison NA, QiJC, Tokita A, Kelly PJ, Crofts L, Nguycn TV, Sambrook PN, Eisman JA: Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287, 1994
107. Schräder M, Nayeri S, Kahlen J-P, Müller KM, Carlberg C: Natural vitamin D3 response elements formed by inverted palindromes: polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid x receptor heterodimer-mediated transactivation. Mol Cell Biol 15:1154-1161, 1995
108. Schräder M, Bendik I, Becker-André M, Carlberg C: Interaction between retinoic acid and vitamin D signaling pathways. J Biol Client 267:1783017836, 1993