M40403, a superoxide dismutase mimetic, protects cochlear hair cells from gentamicin, but not cisplatin toxicity

Toxicology and Applied Pharmacology

Volumn 186, Issue 1, 2003, Pages 46-54

  McFadden, Sandra L ^a   Ding, Dalian ^a   Salvemini, Daniela ^b   Salvi, Richard J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b MetaPhore Pharmaceuticals   (United States)

Author keywords

Cisplatin; Cochlea; Gentamicin; Inner hair cell; M40403; Ototoxicity; Outer hair cell; Superoxide dismutase

Indexed keywords

CISPLATIN; GENTAMICIN; HYDROGEN PEROXIDE; MANGANESE; MANGANESEDICHLORO(3,10,13,20,26 PENTAAZATETRACYCLO[20.3.1.0(4,9).0(14,19)] 1(26),22(23),24 HEXACOSATRIENE); OXYGEN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROTECTION; COCHLEA; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVITY; HAIR CELL; MOUSE; NONHUMAN; OTOTOXICITY;

EID: 0037289175     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(02)00017-0     Document Type: Article

References (59)

1. Barton-Davis E.R., Cordier L., Shoturma D.I., Leland S.E., Sweeney H.L. Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J. Clin. Invest. 104:1999;375-381.
2. Clerici W.J., DiMartino D.L., Prasad M.R. Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro. Hear. Res. 84:1995;30-40.
3. Clerici W.J., Hensley K., DiMartino D.L., Butterfield D.A. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear. Res. 98:1996;116-124.
4. Coppey L.J., Gellett J.S., Davidson E.P., Dunlap J.A., Lund D.D., Salvemini D., Yorek M.A. Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Br. J. Pharmacol. 134:2001;21-29.
5. Covens A., Carey M., Bryson P., Verma S., Fung Kee Fung M., Johnston M. Systematic review of first-line chemotherapy for newly diagnosed postoperative patients with stage II, III, or IV epithelial ovarian cancer. Gynecol. Oncol. 85:2002;71-80.
6. Crow J.P., Beckman J.S. Reactions between nitric oxide, superoxide, and peroxynitrite footprints of peroxynitrite in vivo. Adv. Pharmacol. 34:1995;17-43.
7. Cuzzocrea S., Mazzon E., Dugo L., Caputi A.P., Aston K., Riley D.P., Salvemini D. Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. Br. J. Pharmacol. 132:2001;19-29.
8. Cuzzocrea, S., Mazzon, E., Dugo, L., Serraino, I., Di Paola, R., Britti, D., Sarro, A., Pierpaoli, S., Caputi, A.P., Masini, E., Salvemini, D., 2003. A role for superoxide in gentamicin-mediated nephropathy in rat. Eur. J. Pharmacol. (in press).
9. Davis C.A., Nick H.S., Agarwal A. Manganese superoxide dismutase attenuates Cisplatin-induced renal injury importance of superoxide . J. Am. Soc. Nephrol. 12:2001;2683-2690.
10. Dehne N., Lautermann J., Petrat F., Rauen U., de Groot H. Cisplatin ototoxicity involvement of iron and enhanced formation of superoxide anion radicals . Toxicol. Appl. Pharmacol. 174:2001;27-34.
11. Ding D., Stracher A., Salvi R. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear. Res. 164:2002;115-126.
12. Du X.H., Yang C.L. Mechanism of gentamicin nephrotoxicity in rats and the protective effect of zinc-induced metallothionein synthesis. Nephrol. Dial. Transplant. 9:(Suppl. 4):1994;135-140.
13. Flohe L. Superoxide dismutase for therapeutic use clinical experience, dead ends and hopes . Mol. Cell. Biochem. 84:1988;123-131.
14. Forge A., Schacht J. Aminoglycoside antibiotics. Audiol. Neurootol. 5:2000;3-22.
15. Garetz S.L., Altschuler R.A., Schacht J. Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo. Hear. Res. 77:1994;81-87.
16. Garetz S.L., Rhee D.J., Schacht J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hear. Res. 77:1994;75-80.
17. Halliwell B., Gutteridge J.M. 1999;Oxford University Press, Oxford.
18. Hirose K., Hockenbery D.M., Rubel E.W. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear. Res. 104:1997;1-14.
19. Hospers G.A., Eisenhauer E.A., de Vries E.G. The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents a review, indications for use and prospects . Br. J. Cancer. 80:1999;629-638.
20. Howell S.B., Taetle R. Effect of sodium thiosulfate on cis- dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia. Cancer Treat. Rep. 64:1980;611-616.
21. Howell S.B., Pfeifle C.L., Wung W.E., Olshen R.A., Lucas W.E., Yon J.L., Green M. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann. Intern. Med. 97:1982;845-851.
22. Hu B.H., McFadden S.L., Salvi R.J., Henderson D. Intracochlear infusion of buthionine sulfoximine potentiates carboplatin ototoxicity in the chinchilla. Hear. Res. 124:1999;125-134.
23. Husain K.C., Whitworth C., Somani S.M., Rybak L.P. Carboplatin-induced oxidative stress in rat cochlea. Hear. Res. 159:2001;14-22.
24. Jadot G., Vaille A., Maldonado J., Vanelle P. Clinical pharmacokinetics and delivery of bovine superoxide dismutase. Clin. Pharmacokinet. 28:1995;17-25.
25. Lautermann J., McLaren J., Schacht J. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hear. Res. 86:1995;15-24.
26. Lysiak J.J., Nguyen Q.A., Turner T.T. Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion. J. Androl. 23:2002;400-409.
27. Macarthur H., Westfall T.C., Riley D.P., Misko T.P., Salvemini D. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc. Natl. Acad. Sci. USA. 97:2000;9753-9758.
28. Masuda H., Tanaka T., Tateishi M., Naito M., Tamai H. Detection and cytotoxicity of cisplatin-induced superoxide anion in monolayer cultures of a human ovarian cancer cell line. Cancer Chemother. Pharmacol. 47:2001;155-160.
29. McClay E.F., Howell S.B. A review intraperitoneal cisplatin in the management of patients with ovarian cancer . Gynecol. Oncol. 36:1990;1-6.
30. McCord J.M., Russell W.J. Inactivation of creatine phosphokinase by superoxide during reperfusion injury. Basic Life Sci. 49:1988;869-873.
31. McFadden S.L., Ding D., Reaume A.G., Flood D.G., Salvi R.J. Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol. Aging. 20:1999;1-8.
32. McFadden S.L., Ding D., Burkard R.F., Jiang H., Reaume A.G., Flood D.G., Salvi R.J. Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice. J. Comp. Neurol. 413:1999;101-112.
33. McFadden S.L., Ding D., Ohlemiller K.K., Salvi R.J. The role of superoxide dismutase in age-related and noise-induced hearing loss Clues from SOD1 knockout mice . Willott J.F. Handbook of Mouse Auditory Research. 2001;489-504 CRC Press, Boca Raton, FL.
34. McFadden S.L., Ohlemiller K.K., Ding D., Salvi R.J. The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice. Noise and Health. 3:2001;49-64.
35. McInnis J., Wang C., Anastasio N., Hultman M., Ye Y., Salvemini D., Johnson K.M. The role of superoxide and nuclear factor-kappaB signaling in N-methyl-D-aspartate-induced necrosis and apoptosis. J. Pharmacol. Exp. Ther. 301:2002;478-487.
36. Moroso M.J., Blair R.L. A review of cis-platinum ototoxicity. J. Otolaryngol. 12:1983;365-369.
37. Mulherin D., Fahy J., Grant W., Keogan M., Kavanagh B., FitzGerald M. Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Ir. J. Med. Sci. 160:1991;173-175.
38. Ohlemiller K.K., McFadden S.L., Ding D.L., Flood D.G., Reaume A.G., Hoffman E.K., Scott R.W., Wright J.S., Putcha G.V., Salvi R.J. Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol. Neurootol. 4:1999;237-246.
39. Petkau A. Scientific basis for the clinical use of superoxide dismutase. Cancer Treat. Rev. 13:1986;17-44.
40. Pierson M.G., Gray B.H. Superoxide dismutase activity in the cochlea. Hear. Res. 6:1982;141-151.
41. Ravi R., Somani S.M., Rybak L.P. Mechanism of cisplatin ototoxicity antioxidant system . Pharmacol. Toxicol. 76:1995;386-394.
42. Rybak L.P., Ravi R., Somani S.M. Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity antioxidant system . Fundam. Appl. Toxicol. 26:1995;293-300.
43. Rybak L.P., Husain K., Evenson L., Morris C., Whitworth C., Somani S.M. Protection by 4-methylthiobenzoic acid against cisplatin-induced ototoxicity antioxidant system . Pharmacol. Toxicol. 81:1997;173-179.
44. Rybak L.P., Whitworth C., Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope. 109:1999;1740-1744.
45. Rybak L.P., Husain K., Morris C., Whitworth C., Somani S. Effect of protective agents against cisplatin ototoxicity. Am. J. Otol. 21:2000;513-520.
46. Salvemini D., Wang Z.Q., Zweier J.L., Samouilov A., Macarthur H., Misko T.P., Currie M.G., Cuzzocrea S., Sikorski J.A., Riley D.P. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science. 286:1999;304-306.
47. Salvemini D., Riley D. Nonpeptidyl mimetic of superoxide dismutase in clinical therapies for diseases. Cell. Mol. Life Sci. 57:2000;1489-1492.
48. Salvemini D., Mazzon E., Dugo L., Serraino I., De Sarro A., Caputi A.P., Cuzzocrea S. Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic. Arthritis Rheum. 44:2001;2909-2921.
49. Seidman M.D., Quirk W.S., Nuttall A.L., Schweitzer V.G. The protective effects of allopurinol and superoxide dismutase-polyethylene glycol on ischemic and reperfusion-induced cochlear damage. Otolaryngol. Head Neck Surg. 105:1991;457-463.
50. Seidman M.D., Shivapuja B.G., Quirk W.S. The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage. Otolaryngol. Head Neck Surg. 109:1993;1052-1056.
51. Sha S., Taylor R., Forge A., Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear. Res. 155:2001;1-8.
52. Sha S.H., Schacht J. Stimulation of free radical formation by aminoglycoside antibiotics. Hear. Res. 128:1999;112-118.
53. Sha S.H., Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo D-methionine is a potential protectant . Hear. Res. 142:2000;34-40.
54. Sha S.H., Zajic G., Epstein C.J., Schacht J. Overexpression of copper/zinc- superoxide dismutase protects from kanamycin-induced hearing loss. Audiol. Neurootol. 6:2001;117-123.
55. Takumida M., Anniko M., Popa R. Possible involvement of free radicals in lipopolysaccharide-induced labyrinthitis in the guinea pig a morphological and functional investigation . ORL J. Otorhinolaryngol. Relat. Spec. 60:1998;246-253.
56. Takumida M., Popa R., Anniko M. Free radicals in the guinea pig inner ear following gentamicin exposure. ORL J. Otorhinolaryngol. Relat. Spec. 61:1999;63-70.
57. Walker P.D., Barri Y., Shah S.V. Oxidant mechanisms in gentamicin nephrotoxicity. Renal Failure. 21:1999;433-442.
58. Zhang Y., Marcillat O., Giulivi C., Ernster L., Davies K.J. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265:1990;16330-16336.
59. Zheng J.L., Gao W.Q. Differential damage to auditory neurons and hair cells to ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures. Eur. J. Neurosci. 8:1996;1897-1905.