Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains

Behavioral Neuroscience

Volumn 111, Issue 2, 1997, Pages 292-300

  Owen, Elizabeth H ^a   Christensen, Steven C ^a   Paylor, Richard ^a   Wehner, Jeanne M ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; AUDITORY STIMULATION; BEHAVIOR MODIFICATION; CHROMOSOME 1; CHROMOSOME 12; CHROMOSOME 17; CONDITIONING; FEAR; GENE LOCUS; LEARNING; MOUSE; NONHUMAN; QUANTITATIVE TRAIT; STIMULUS RESPONSE; TASK PERFORMANCE;

ANIMALS; AROUSAL; ASSOCIATION LEARNING; CHROMOSOME MAPPING; CONDITIONING, CLASSICAL; FEAR; FEMALE; GENETIC MARKERS; INDIVIDUALITY; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MODELS, GENETIC; RECOMBINATION, GENETIC;

EID: 0030992367     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.111.2.292     Document Type: Article

References (34)

1. Belknap, J. K, Metten, P., Helms, M. L., O'Toole, L. A., Angeli-Gade, S., Crabbe, J. C., & Phillips, T. J. (1993). Quantitative trait loci (QTL) applications to substances of abuse: Physical dependence studies with nitrous oxide and ethanol in BXD mice. Behavior Genetics, 23, 213-222.
2. Belknap, J. K., Mitchell, S. R., O'Toole, L. A., Helms, M. L., & Crabbe, J. C. (1996). Type I and Type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains, Behavior Genetics, 26, 149-160.
3. Bowers, B. J., Christensen, S. C., Pauley, J. R., Paylor, R., Yuva, L., Dunbar, S. E., & Wehner, J. M. (1995). Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice. Journal of Neurochemistry, 64, 2737-2746.
4. Buck, K. J. (1995). Strategies for mapping and identifying quantitative trait loci specifying behavioral responses to alcohol. Alcoholism: Clinical and Experimental Research, 19, 795-801.
5. Deitrich, W. F., Miller, J. C., Steen, R. G., Merchant, M., Damron, D., Nahf, R., Gross, A., Joyce, D. C., Wessel, M., Dredge, R. D., Marquis, A., Stein, L. D., Goodman, N., Page, D. C., & Lander, E. S. (1994). A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genetics, 7, 220-245.
6. Erway, L. C., Willott, J. F., Archer, J. R., & Harrison, D. E. (1993). Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains. Hearing Research, 65, 125-132.
7. Falconer, D. S. (1989). Introduction to quantitative genetics (3rd ed.). Essex, England: Longman Scientific & Technical.
8. Fanselow, M. S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin & Review, 1, 429-438.
9. Flint, J., Corley, R., DeFries, J. C., Fulker, D. W., Gray, J. A., Miller, S., & Collins, A. C. (1995, September 8). A simple genetic basis for a complex psychological trait in laboratory mice. Science, 269, 1432-1435.
10. Fulker, D. W., Markel, P. D., DeFries, J. C., Corley, R. P., Johnson, T. E. (1994). Use of interval mapping to localize quantitative trait loci in recombinant inbred strains. Alcoholism: Clinical and Experimental Research, 18, 452.
11. Gora-Maslak, G., McClearn, G. E., Crabbe, J. C., Phillips, T. J., Belknap, J. K., & Plomin, R. (1991). Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology, 104, 413-424.
12. Johnson, T. E., DeFries, J. C., & Markel, P. D. (1992). Mapping quantitative trait loci for behavioral traits in the mouse. Behavior Genetics, 22, 635-653.
13. Kim, J. J., & Fanselow, M. S. (1992, May 1). Modality-specific retrograde amnesia of fear. Science, 256, 675-676.
14. Lander, E., & Kruglyak, L. (1995). Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nature Genetics, 11, 241-247.
15. Lander, E. S., & Botstein, D. (1989). Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics, 121, 185-199.
16. Logue, S. F., Paylor, R., & Wehner, J. M. (in press). Hippocampal lesions cause learning deficits in inbred mice in Morris water maze and conditioned fear tasks. Behavioral Neuroscience.
17. Manly, K., & Cudmore, R. (1994). Map Manager, version 2.6. http://mcbio.med.buffalo.edu/mapmgr.html
18. Mathis, C., Neumann, P. E., Gershenfeld, H., Paul, S. M., & Crawley, J. N. (1995). Genetic analysis of anxiety-related behaviors and responses to benzodiazepine-related drugs in AXB and BXA recombinant inbred mouse strains. Behavior Genetics, 25, 557-568.
19. Mouse Genome Database (1995). http://www.informatics.jax.org/ mgd.html
20. Neumann, P. E. (1992). Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice. Behavior Genetics, 22, 665-676.
21. Neumann, P. E., & Collins, R. L. (1991). Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proceedings of the National Academy of Sciences, USA, 88, 5408-5412.
22. Owen, E. H., Logue, S. F., Rasmussen, D. L., & Wehner, J. M. (in press). Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience.
23. Paylor, R., Tracy, R., Wehner, J. M., & Rudy, J. W. (1994). DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. Behavioral Neuroscience, 108, 1-8.
24. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
25. Phillips, R. G., & LeDoux, J. E. (1994). Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learning and Memory, 1, 34-44.
26. Plomin, R., McClearn, G. E., Gora-Maslak, G., & Neiderhiser, J. M. (1991). Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. Behavior Genetics, 21, 99-116.
27. Rudy, J. W. (1993). Contextual conditioning and auditory cue conditioning dissociate during development. Behavioral Neuroscience, 107, 887-891.
28. Rudy, J. W. (1996). Post-conditioning isolation disrupts contextual fear conditioning: An experimental analysis. Behavioral Neuroscience, 110, 238-246.
29. Rudy, J. W., & Morledge, P. (1994). Ontogeny of contextual fear conditioning in rats: Implications for consolidation, infantile amnesia, and hippocampal system function. Behavioral Neuroscience, 108, 227-234.
30. Seyfried, T. N. (1982). Developmental genetics of audiogenic seizure susceptibility in mice. In V. E. Anderson, W. A. Hauser, J. K. Penry, & C. F. Sing (Eds.), Genetic basis of the epilepsies (pp. 199-210). New York: Raven Press.
31. Silver, L. M. (1995). Classical linkage analysis and mapping panels. Mouse genetics: Concepts and applications (pp. 195-263). New York: Oxford University Press.
32. Tarricone, B. J., Hingtgen, J. N., Belknap, J. K., Mitchell, S. R., & Nurnberger, J. I., Jr. (1995). Quantitative trait loci associated with the behavioral response of BXD recombinant inbred mice to restraint stress: A preliminary communication. Behavior Genetics, 25, 489-495.
33. Taylor, B. A. (1989). Recombinant inbred strains. In M. F. Lyon, A. G. Searle (Eds.), Genetic variants and strains of the laboratory mouse (2nd ed.). Oxford, England: Oxford University Press.
34. Wehner, J. M., Sleight, S., & Upchurch, M. (1990). Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Research, 523, 181-187.