Tubular NF-κB and AP-1 activation in human proteinuric renal disease

Kidney International

Volumn 60, Issue 4, 2001, Pages 1366-1377

  Mezzano, Sergio A ^a,b   Barria, Miguel ^a,b   Droguett, M Alejandra ^a,b   Burgos, M Eugenia ^a,b   Ardiles, Leopoldo G ^a,b   Flores, Claudio ^a,b   Egido, Jesús ^a,b  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Activator protein 1; Membranous nephropathy; Minimal change disease; Monocyte chemoattractant protein 1; Nuclear factor B; Osteopontin; Transforming growth factor

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P50; PROTEIN SUBUNIT; RANTES; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA; AUTACOID;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE COURSE; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IDIOPATHIC DISEASE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY CELL; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; MALE; MINIMAL CHANGE GLOMERULONEPHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; CYTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TUBULE; LIPOID NEPHROSIS; MEMBRANOUS GLOMERULONEPHRITIS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; REFERENCE VALUE; URINE;

ADOLESCENT; ADULT; CHEMOKINES; CHILD; CHILD, PRESCHOOL; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION MEDIATORS; KIDNEY TUBULES; MALE; NEPHROSIS, LIPOID; NF-KAPPA B; PROTEINURIA; REFERENCE VALUES; TRANSCRIPTION FACTOR AP-1;

EID: 0034740805     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.00941.x     Document Type: Article

References (32)

1. Understanding the nature of renal disease progression
2. Activation of nuclear factor κB in tubular epithelial cells of rats with intense proteinuria: Role of angiotensin II and endothelin- 1
3. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria
4. Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein
5. In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation
6. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation
7. Tubular-derived growth factors and cytokines in the pathogenesis of tubulointerstitial fibrosis: Implications for human renal disease progression
8. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
9. NF-κB: A lesson in family values
10. Signal transduction through NF-κB
11. AP-1 function and regulation
12. AP-1, one switch for many signals
13. Interstitial nephritis induced by protein-overload proteinuria
14. Inhibition of nuclear factor-kappa B activation reduces cortical tubulointerstitial injury in proteinuric rats
15. In situ nonradioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry
16. Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy
17. Angiotensin in progressive renal diseases: Theory and practice
18. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor κB in proximal tubule cells
19. Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria
20. Transcription factor κB (NF-κB) and cardiovascular diseases
21. Stimulus-specific regulation of chemokine expression involves tial activation of the redox-responsive transcription factors AP-1 and NF-kappaB
22. Regulation of gene expression
23. Involvement of Ets transcription factors and targets in osteoblast differentiation and matrix mineralization
24. AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-β1 promoter in mesangial cells
25. Transcription factor κB (NF-κB) in renal disease
26. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis
27. Angiotensin II activates nuclear transcription factor κB through AT1 and AT2 in vascular smooth muscle cells: Molecular mechanisms
28. Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappaB activation and monocyte chemoattractant protein-1 synthesis
29. Enalapril decreases nuclear factor κB activation in the kidney with ureteral obstruction
30. Progression of renal failure and lipids: Is there evidence of a link in humans
31. Red wine intake prevents nuclear factor-κB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia
32. In vivo administration of a nuclear transcription factor-κB decoy suppresses experimental crescentic glomerulonephritis