IκB kinase is critical for TNF-α-induced VCAM1 gene expression in renal tubular epithelial cells

Journal of Immunology

Volumn 166, Issue 11, 2001, Pages 6839-6846

  Tu, Zheng ^a   Kelley, Vicki Rubin ^b   Collins, Tucker ^b   Lee, Frank S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; I KAPPA B KINASE; INTEGRIN; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEASOME; PROTEIN P50; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; KIDNEY GRAFT REJECTION; KIDNEY TUBULE CELL; LEUKOCYTE ACTIVATION; LYMPHOCYTE; MONOCYTE; MOUSE; NEPHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

EID: 0035337720     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.11.6839     Document Type: Article

References (63)

1. Bruijn, J. A., and E. de Heer. 1995. Adhesion molecules in renal diseases. Lab. Invest. 72:387.
2. Briscoe, D. M., and R. S. Cotran. 1993. Role of leukocyte-endothelial cell adhesion molecules in renal inflammation: in vitro and in vivo studies. Kidney Int. Suppl. 42:S27.
3. Rabb, H. A. 1994. Cell adhesion molecules and the kidney. Am. J. Kidney Dis. 23:155.
4. Brady, H. R. 1994. Leukocyte adhesion molecules and kidney diseases. Kidney Int. 45:1285.
5. Croker, B. P., and E. L. Ramos. 1994. Pathology of the renal allograft. In Renal Pathlogy with Clinical and Functional Correlations, Vol. 2. C. C. Tisher and B. M. Brenner, eds. J. B. Lippincott Company, Philadelphia, PA, p. 1591.
6. Briscoe, D. M., J. S. Pober, W. E. Harmon, and R. S. Cotran. 1992. Expression of vascular cell adhesion molecule-1 in human renal allografts. J. Am. Soc. Nephrol. 3:1180.
7. Alpers, C. E., K. L. Hudkins, C. L. Davis, C. L. Marsh, W. Riches, J. M. McCarty, C. D. Benjamin, T. M. Carlos, J. M. Harlan, and R. Lobb. 1993. Expression of vascular cell adhesion molecule-1 in kidney allograft rejection. Kidney Int. 44:805.
8. Lin, Y., J. A. Kirby, D. A. Browell, A. R. Morley, B. K. Shenton, G. Proud, and R. M. Taylor. 1993. Renal allograft rejection: expression and function of VCAM-1 on tubular epithelial cells. Clin. Exp. Immunol. 92:145.
9. Elices, M. J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M. E. Hemler, and R. R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60:577.
10. Carlos, T. M., B. R. Schwartz, N. L. Kovach, E. Yee, M. Rosa, L. Osborn, G. Chi-Rosso, B. Newman, R. Lobb, M. Rosso, and et al. 1990. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76:965.
11. 7 on the human B cell line JY. J. Biol. Chem. 267:8366.
12. Osborn, L., C. Hession, R. Tizard, C. Vassallo, S. Luhowskyj, G. Chi-Rosso, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203.
13. Li, H., M. I. Cybulsky, M. A. Gimbrone, Jr., and P. Libby. 1993. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma. Am. J. Pathol. 143:1551.
14. Iademarco, M. F., J. J. McQuillan, and D. C. Dean. 1993. Vascular cell adhesion molecule 1: contrasting transcriptional control mechanisms in muscle and endothelium. Proc. Natl. Acad. Sci. USA 90:3943.
15. Wuthrich, R. P., T. A. Jenkins, and T. L. Snyder. 1993. Regulation of cytokine-stimulated vascular cell adhesion molecule-1 expression in renal tubular epithelial cells. Transplantation 55:172.
16. Sheppard, A. M., J. J. McQuillan, M. F. Iademarco, and D. C. Dean. 1995. Control of vascular cell adhesion molecule-1 gene promoter activity during neural differentiation. J. Biol. Chem. 270:3710.
17. Freedman, A. S., J. M. Munro, G. E. Rice, M. P. Bevilacqua, C. Morimoto, B. W. McIntyre, K. Rhynhart, J. S. Pober, and L. M. Nadler. 1990. Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science 249:1030.
18. Burkly, L. C., A. Jakubowski, B. M. Newman, M. D. Rosa, G. Chi-Rosso, and R. R. Lobb. 1991. Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation. Eur. J. Immunol. 21:2871.
19. + T lymphocytes. Proc. Natl. Acad. Sci. USA 88:6403.
20. Miyake, K., K. Medina, K. Ishihara, M. Kimoto, R. Auerbach, and P. W. Kincade. 1991. A VCAM-like adhesion molecule on marine hone marrow stromal cells mediates binding of lymphocyte precursors in culture. J Cell Biol. 114:557.
21. Briscoe, D. M., F. J. Schoen, G. E. Rice, M. P. Bevilacqua, P. Ganz, and J. S. Pober. 1991. Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts. Transplantation 51:537.
22. Postigo, A. A., R. Garcia-Vicuna, F. Diaz-Gonzalez, A. G. Arroyo, M. O. De Landazuri, G. Chi-Rosso, R. R. Lobb, A. Laffon, and F. Sanchez-Madrid. 1992. Increased binding of synovial T lymphocytes from rheumatoid arthritis 10 endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1). J. Clin. Invest. 89: 1445.
23. Wuthrich, R. P. 1992. Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis. Kidney Int. 42:903.
24. Koizumi, M., N. King, R. Lobb, C. Benjamin, and D. K. Podolsky. 1992. Expression of vascular adhesion molecules in inflammatory bowel disease. Gastroenterology 103:840.
25. Cybulsky, M. I., and M. A. Gimbrone, Jr. 1991. Endothelial expression of a munonuclear leukocyte adhesion molecule during atherogenesis. Science 251: 788.
26. Gurtner, G. C., V. Davis, H. Li, M. J. McCoy, A. Sharpe, and M. I. Cybulsky. 1995. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 9:1.
27. Neish, A. S., A. J. Williams, H. J. Palmer, M. Z. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion molecule 1 promoter. J. Exp. Med. 176:1583.
28. Iademarco, M. F., J. J. McQuillan, G. D. Rosen, and D. C. Dean. 1992. Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J. Biol. Chem. 267:16323.
29. Shu, H. B., A. B. Agranoff, K. G. Nabel, K. Leung, C. S. Duckett, A. S. Neish, T. Collins, and G. J. Nabel. 1993. Differential regulation of vascular cell adhesion molecule 1 gene expression by specilic NF-κB subunits in endothelial and epithelial cells. Mol. Cell Biol. 13:6283.
30. Wuthrich, R. P., L. H. Glimcher, M. A. Yui, A. M. Jevnikar, S. E. Dumas, and V. E. Kelley. 1990. MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Kidney Int. 37:783.
31. Zhao, Q., and F. S. Lee. 1999. Mitogen-activated protein Kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β. J. Biol. Chem. 274:8355.
32. Cybulsky, M. I., J. W. Fries, A. J. Williams, P. Sultan, R. Eddy, M. Byers, T. Shows, M. A. Gimbrone, Jr., and T. Collins. 1991. Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc. Natl. Acad. Sci. USA 88:7859.
33. Brockman, J. A., D. C. Scherer, T. A. McKinsey, S. M. Hall, X. Qi, W. Y. Lee, and D. W. Ballard. 1995. Coupling of a signal response domain in IκB α to multiple pathways for NF-κB activation. Mol. Cell Biol. 15:2809.
34. Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373.
35. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
36. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the κB α kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213.
37. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
38. Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase α and IκB kinase β. Proc. Natl. Acad Sci. USA 95:9319.
39. Ashkenazi, A., and V. M. Dixit. 1998. Death receptors: signaling and modulation. Science 281:1305.
40. Natoli, G., A. Costanzo, F. Moretti, M. Fulco, C. Balsano, and M. Levrero. 1997. Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2: nuclear factor κB (NFκB)-inducing kinase requirement for activation of activating protein 1 and NFκB but not of c-Jun N-terminal kinase/ stress-activated protein kinase. J. Biol. Chem. 272:26079.
41. Lenardo, M. J., and D. Baltimore. 1989. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227.
42. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
43. Zandi, E., and M. Karin. 1999. Bridging the gap: composition, regulation, and physiological function of the IκB kinase complex. Mol. Cell Biol. 19:4547.
44. Karin, M. 1999. The beginning of the end: IκB kinase (IKK) and NF-κB activation. J. Biol. Chem. 274:27339.
45. Stancovski, L. and D. Baltimore. 1997. NF-κB activation: the IκB kinase revealed? Cell 91:299.
46. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
47. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537.
48. Simeonidis, S., S. Liang, G. Chen, and D. Thanos. 1997. Cloning and functional characterization of mouse IκBε. Proc. Natl. Acad. Sci. USA 94:14372.
49. Whiteside, S. T., J. C. Epinat, N. R. Rice, and A. Israel. 1997. IκBε, a novel member of the IκB family, controls RelA and cRel NF-κB activity. EMBO J. 16: 1413.
50. Papi, A., and S. L. Johnston. 1999. Respiratory epithelial cell expression of vascular cell adhesion molecule-1 and its up-regulation by rhinovirus infection via NF-κB and GATA transcription factors. J. Biol. Chem. 274:30041.
51. Li, N., and M. Karin. 1998. Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms. Proc. Natl. Acad. Sci. USA 95:13012.
52. Imbert, V., R. A. Rupec, A. Livolsi, H. L. Pahl, E. B. Traenckner, C. Mueller-Dieckmann, D. Farahifar. B. Rossi, P. Auberger, P. A. Baeuerle, and J. F. Peyron. 1996. Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 86:787.
53. Canty, T. G., Jr., E. M. Boyle, Jr., A. Farr, E. N. Morgan, E. D. Verrier, and T. H. Pohlman. 1999. Oxidative stress induces NF-κB nuclear translocation without degradation of IκBα. Circulation 100:11361.
54. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
55. Sun, S. C., P. A. Ganchi, D. W. Ballard, and W. C. Greene. 1993. NF-κ B controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259:1912.
56. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κ B. Cell 80:573.
57. Tanaka, M., M. E. Fuentes, K. Yamaguchi, M. H. Durnin, S A. Dalrymple, K. L. Hardy, and D. V. Goeddel. 1999. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice. Immunity 10:421.
58. Li, Q., D. Van Antwerp, F. Mercurio, K. F. Lee, and I. M. Verma. 1999. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284:321.
59. Li, Z. W., W. Chu, Y. Hu, M. Delhase, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin. 1999. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J. Exp. Med. 189:1839.
60. Hu, Y., V. Baud, M. Delhase, P. Zhang, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin. 1999. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284:316.
61. Takeda, K., O. Takeuchi, T. Tsujimura, S. Itami, O. Adachi, T. Kawai, H. Sanjo, K. Yoshikawa, N. Terada, and S. Akira. 1999. Limb and skin abnormalities in mice lacking IKKα. Science 284:313.
62. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167.
63. Vos, I. H., R. Covers, H. J. Grone, L. Kleij, M. Schurink, R. A. De Weger, R. Goldschmeding, and T. J. Rabelink. 2000. NFκB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts. FASEB J. 14:815.