Synthesis of high specific activity 35S-labelled N-methanesulfonyl farnesylcysteine and a photoactive analog

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 46, Issue 1, 2003, Pages 29-54

  Kale, Tamara A ^a   Raab, Conrad ^b   Yu, Nathan ^b   Aquino, Evelyn ^b   Dean, Dennis C ^b   Distefano, Mark D ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

35S; Isoprenoid binding site; Photoaffinity labelling; Prenylcysteine; RhoGDI

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CRYSTAL STRUCTURE; ESTERS; LIPIDS; PROTEINS;

35S; BINDING-SITES; CYSTEINE RESIDUES; GTP-BINDING PROTEINS; HIGH SPECIFIC ACTIVITIES; ISOPRENOID BINDING SITE; ISOPRENOIDS; PHOTOAFFINITY LABELING; PRENYLCYSTEINE; RHOGDI;

PHOTOLYSIS;

ACETYLCYSTEINE DERIVATIVE; CYSTEINE DERIVATIVE; N METHANESULFONYLFARNESYLCYSTEINE; UNCLASSIFIED DRUG;

AFFINITY LABELING; ARTICLE; BINDING SITE; CHEMICAL REACTION; COMPETITIVE INHIBITION; COVALENT BOND; CROSS LINKING; CRYSTAL STRUCTURE; ESTERIFICATION; ISOTOPE LABELING; PHOTOLYSIS; PRENYLATION; SYNTHESIS;

BACTERIA (MICROORGANISMS);

EID: 0037238648     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.638     Document Type: Article

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