Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor

Journal of Medicinal Chemistry

Volumn 39, Issue 9, 1996, Pages 1767-1770

  Dean, Dennis C ^a   Nargund, Ravi P ^a   Pong, Sheng Shung ^a   Chaung, Lee Yuh P ^a   Griffin, Patrick ^a   Melillo, David G ^a   Ellsworth, Robert L ^a   Van Der Ploeg, Lex H T ^a   Patchett, Arthur A ^a   Smith, Roy G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO N [2 BENZYLOXY 1 (1,2 DIHYDRO 1 METHANESULFONYLSPIRO[3H INDOLE 3,4' PIPERIDIN 1' YL]CARBONYL)ETHYL] 2 METHYLPROPIONAMIDE; 3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; IBUTAMOREN; RADIOLIGAND; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING AFFINITY; BINDING COMPETITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOPHYSIS CELL; ISOTOPE LABELING; NONHUMAN; RAT; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; INDOLES; MOLECULAR SEQUENCE DATA; RADIOLIGAND ASSAY; RATS; RECEPTORS, SOMATOTROPIN; SPIRO COMPOUNDS; SULFONAMIDES; SULFUR RADIOISOTOPES;

EID: 15844421382     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960054c     Document Type: Review

References (18)

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15. 32S corresponding to a specific activity of 1110 Ci/mmol.
16. 35S]-3a demonstrated remarkable stability (<0.5% loss of radiochemical purity/month) when stored at -20 °C as a solution in 15% methanol-water solution containing a trace of hydrochloric acid.
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