Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis

Diabetologia

Volumn 41, Issue 2, 1998, Pages 171-177

  Cinti, S ^a   Eberbach, S ^a   Castellucci, M ^a   Accili, D ^b,c  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Building 10 ^*  (United States)

Author keywords

Adipocyte; Diabetes mellitus; Genetics; Growth; Receptors

Indexed keywords

INSULIN RECEPTOR; SOMATOMEDIN C RECEPTOR;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ULTRASTRUCTURE; DIABETES MELLITUS; ELECTRON MICROSCOPY; HYPERINSULINEMIA; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE;

EID: 0031888649     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050886     Document Type: Article

References (31)

1. Cheatham B, Kahn CR (1995) Insulin action and the insulin signaling network. Endocr Rev 16: 117-142
2. Accili D (1995) Molecular defects of the insulin receptor gene. Diabetes Metab Rev 11: 47-62
3. Moller DE, Flier JS (1991) Insulin resistance-mechanisms, syndromes, and implications. N Engl J Med 325: 938-948
4. Taylor SI (1992) Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes 41: 1473-1490
5. Accili D, Drago J, Lee EJ, et al. (1996) Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 12: 106-109
6. Accili D (1997) Insulin receptor knock-out mice. Trends Endocrinol Metab 8: 101-104
7. Joshi RL, Lamothe B, Cordonnier N, et al. (1996) Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J 15: 1542-1547
8. Louvi A, Accili D, Efstratiadis A (1997) Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol: 189: 33-48
9. Duvillie B, Cordonnier N, Deltour L, et al. (1997) Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci USA 94: 5137-5140
10. Naeye RL (1965) Infants of diabetic mothers: a quantitative, morphologic study. Pediatrics 35: 980-988
11. Fee JM, Weil WB (1963) Body composition of infants of diabetic mothers by direct analysis. Annals New York Acad Sci 110: 869-897
12. Milner RDG (1996) Nesidioblastosis unravelled. Arch Dis Child 74: 369-372
13. Widdowson EM (1950) Chemical composition of newly born mammals. Nature 166: 626-628
14. Weibel E (1979) Stereological methods, practical methods for biological morphometry. Academic Press, London
15. Roth SI, Schedewie HK, Herzberg VK, et al. (1981) Cutaneous manifestations of leprechaunism. Arch Dermatol 117: 531-535
16. Napolitano L (1963) The differentiation of while adipose tissue: an electron microscopic study. J Cell Biol 18: 663-673
17. Slavin B (1979) Fine structural studies on white adipocyte differentiation. Anat Rec 195: 63-72
18. Cinti S, Cigolini M, Bosello O, Bjorntorp P (1984) A morphological study of the adipocyte precursor. J Submicrosc Cytol 16: 243-251
19. Ailhaud G, Dani C, Gaillard D, Grimaldi P, Negrel R (1992) Critical steps and hormonal control of adipose cell differentiation. Pediatr Adolesc Med 2: 115-124
20. Ailhaud G, Grimaldi P, Negrel R (1994) Hormonal regulation of adipose differentiation. Trends Endocrinol Metab 5: 132-136
21. Glickman RM, Sabesin SM (1994) Lipoprotein Metabolism. In: Arias IM, Boyer JL, Fausto N et al. (eds). The liver: biology and pathobiology. Raven Press, New York pp. 391-402
22. Morrione A, Valentinis B, Xu S-Q, et al. (1997) IGF-II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci USA 94: 3777-3782
23. Ogata ES, Sabbagha R, Metzger BE, et al. (1980) Serial ultrasonography to assess evolving fetal macrosomia. J Am Med Assoc 243: 2405-2408
24. Tyrala EE (1996) The infant of the diabetic mother. Obstet Gynecol Clin North Am 23: 221-241
25. Rubin CS, Hirsch A, Fung C, Rosen OM (1978) Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem 253: 7570-7578
26. Smith PJ, Wise LS, Berkowitz R, Wan C, Rubin CS (1988) Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J Biol Chem 263: 9402-9408
27. Di Cola G, Cool MH, Accili D (1997) Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. J Clin Invest 99: 2538-2544
28. Accili D, Taylor SI (1991) Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination. Proc Natl Acad Sci U S A 88: 4708-4712
29. Brunzell JD, Chait A (1990) Lipoprotein pathophysiology and treatment In: Rifkin H, Dorte DJ (eds) Ellenberg and Rifkin's diabetes mellitus. Elsevier, New York pp. 756-768
30. Girard J, Ferre P, Pegorier JP, Duee PH (1992) Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol Rev 72: 507-562
31. Pegorier JP, Prip BC, Duee PH, Girard J (1992) Hormonal control of fatty acid oxidation during the neonatal period. Diabete Metab 18: 156-160