Molsidomine ameliorates experimental allergic encephalomyelitis in Lewis rats

Immunopharmacology and Immunotoxicology

Volumn 25, Issue 1, 2003, Pages 41-52

  Kwak, H J ^a   Pae, H O ^a   Oh, G S ^a   Choi, B M ^a   Jang, S I ^a   Jung, S ^a   Chung, H T ^a  

^a Wonkwang University School of Medicine   (South Korea)

Author keywords

Experimental allergic encephalomyelitis; Molsidomine; Nitric oxide

Indexed keywords

GAMMA INTERFERON; MOLSIDOMINE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CYTOKINE RELEASE; DEMYELINATING DISEASE; DISEASE SEVERITY; INFLAMMATORY CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK BENEFIT ANALYSIS; T LYMPHOCYTE ACTIVATION; TISSUE INJURY;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-10; MALE; MOLSIDOMINE; MYELIN BASIC PROTEINS; MYELITIS; NITRIC OXIDE DONORS; RATS; RATS, INBRED LEW;

ANIMALIA;

EID: 0037232413     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.1081/IPH-120018282     Document Type: Article

References (34)

1. Kuchroo, V.K.; Anderson, A.C.; Waldner, H.; Munder, M.; Bettelli, E.; Nicholson, L.B. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 2002, 20, 101-123.
2. Ludowyk, P.A.; Hughes, W.; Hugh, A.; Willenborg, D.O.; Rockett, K.A.; Parish, C.R. Astrocytic hypertrophy: an important pathological feature of chronic experimental autoimmune encephalitis in aged rats. J. Neuroimmunol. 1993, 48, 121-134.
3. Hemmer, B.; Archelos, J.J.; Hartung, H.P. New concepts in the immunopathogenesis of multiple sclerosis. Nat. Rev. Neurosci. 2002, 3 (4), 291-301.
4. Maron, R.; Hancock, W.W.; Slavin, A.; Hattori, M.; Kuchroo, V.; Weiner, H.L. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int. Immunol. 1999, 11 (9), 1573-1580.
5. Kroncke, K.D.; Fehsel, K.; Suschek, C.; Kolb-Bachofen, V. Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival. Int. Immunopharmacol. 2001, 1 (8), 1407-1420.
6. Teixeira, S.A.; Castro, G.M.; Papes, F.; Martins, M.L.; Rogerio, F.; Langone, F.; Santos, L.M.; Arruda, P.; de Nucci, G.; Muscara, M.N. Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis. Brain Res. Mol. Brain Res. 2002, 99 (1), 17-25.
7. Rodriguez-Sainz Mdel, C.; Sanchez-Ramon, S.; Andres, C.D.; Rodriguez-Mahou, M.; Munoz-Fernandez, M.A. Th1/Th2 cytokine balance and nitric oxide in cerebrospinal fluid and serum from patients with multiple sclerosis. Eur. Cytokine Netw. 2002, 13 (1), 110-114.
8. Staykova, M.A.; Cowden, W.; Willenborg, D.O. Macrophages and nitric oxide as the possible cellular and molecular basis for strain and gender differences in susceptibility to autoimmune central nervous system inflammation. Immunol. Cell Biol. 2002, 80 (2), 188-197.
9. Boullerne, A.I.; Rodriguez, J.J.; Touil, T.; Brochet, B.; Schmidt, S.; Abrous, N.D.; Le Moal, M.; Pua, J.R.; Jensen, M.A.; Mayo, W.; Arnason, B.G.; Petry, K.G. Anti-S-nitrosocysteine antibodies are a predictive marker for demyelination in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J. Neurosci. 2002, 22 (1), 123-132.
10. O'Brien, N.C.; Charlton, B.; Cowden, W.B.; Willenborg, D.O. Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease. J. Immunol. 2001, 167 (10), 5904-5912.
11. van der Veen, R.C. Nitric oxide and T helper cell immunity. Int. Immunopharmacol. 2001, 1 (8), 1491-1500.
12. Xu, L.Y.; Yang, J.S.; Link, H.; Xiao, B.G. SIN-1, a nitric oxide donor, ameliorates experimental allergic encephalomyelitis in Lewis rats in the incipient phase: the importance of the time window. J. Immunol. 2001, 166 (9), 5810-5816.
13. Weishaupt, A.; Jander, S.; Bruck, W.; Kuhlmann, T.; Stienekemeier, M.; Hartung, T.; Toyka, K.V.; Stoll, G.; Gold, R. Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: rapid induction of Th1-type cytokines and inducible nitric oxide synthase. J. Immunol. 2000, 165 (12), 7157-7163.
14. Singh, V.K.; Mehrotra, S.; Narayan, P.; Pandey, C.M.; Agarwal, S.S. Modulation of autoimmune diseases by nitric oxide. Immunol. Res. 2000, 22 (1), 1-19.
15. Willenborg, D.O.; Staykova, M.A.; Cowden, W.B. Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review. J. Neuroimmunol. 1999, 100 (1-2), 21-35.
16. Pozza, M.; Bettelli, C.; Aloe, L.; Giardino, L.; Calza, L. Further evidence for a role of nitric oxide in experimental allergic encephalomyelitis: aminoguanidine treatment modifies its clinical evolution. Brain Res. 2000, 855 (1), 39-46.
17. O'Brien, N.C.; Charlton, B.; Cowden, W.B.; Willenborg, D.O. Nitric oxide plays a critical role in the recovery of Lewis rats from experimental autoimmune encephalomyelitis and the maintenance of resistance to reinduction. J. Immunol. 1999, 163 (12), 6841-6847.
18. Willenborg, D.O.; Fordham, S.A.; Staykova, M.A.; Ramshaw, I.A.; Cowden, W.B. IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide. J. Immunol. 1999, 163 (10), 5278-5286.
19. Xu, L.; Huang, Y.; Yang, J.; van der Meide, P.H.; Levi, M.; Wahren, B.; Link, H.; Xiao, B. Dendritic cell-derived nitric oxide is involved in IL4-induced suppression of experimental allergic encephalomyelitis (EAE) in Lewis rats. Clin. Exp. Immunol. 1999, 118 (1), 115-121.
20. Giovannoni, G.; Heales, S.J.; Land, J.M.; Thompson, E.J. The potential role of nitric oxide in multiple sclerosis. Mult. Scler. 1998, 4 (3), 212-216.
21. Fenyk-Melody, J.E.; Garrison, A.E.; Brunnert, S.R.; Weidner, J.R.; Shen, F.; Shelton, B.A.; Mudgett, J.S. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene. J. Immunol. 1998, 160 (6), 2940-2946.
22. Ozturk, H.; Aldemir, M.; Buyukbayram, H.; Dokucu, A.I.; Otcu, S. The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal-a functional and histophatological study. Int. Urol. Nephrol. 2001, 32 (4), 601-607.
23. Tutka, P.; Luszczki, J.; Kleinrok, Z.; Arent, K.; Wiclosz, M. Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. J. Neural Transm. 2002, 109 (4), 455-466.
24. Scott, G.S.; Bolton, C. L-arginine modifies free radical production and the development of experimental allergic encephalomyelitis. Inflamm. Res. 2000, 49 (12), 720-726.
25. Espejo, C.; Penkowa, M.; Saez-Torres, I.; Xaus, J.; Celada, A.; Montalban, X.; Martinez-Caceres, E.M. Treatment with anti-interferon-gamma monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-gamma receptor knockout mice. Exp. Neurol. 2001, 172 (2), 460-468.
26. Croxford, J.L.; Feldmann, M.; Chernajovsky, Y.; Baker, D. Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system. J. Immunol. 2001, 166 (6), 4124-4130.
27. Cross, A.H.; Misko, T.P.; Lin, R.F.; Hickey, W.F.; Trotter, J.L.; Tilton, R.G. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Investig. 1994, 93 (6), 2684-2690.
28. Zhao, W.; Tilton, R.G.; Corbett, J.A.; McDaniel, M.L.; Misko, T.P.; Williamson, J.R.; Cross, A.H.; Hickey, W.F. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. J. Neuroimmunol. 1996, 64 (2), 123-133.
29. Okuda, Y.; Sakoda, S.; Fujimura, H.; Yanagihara, T. Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase. J. Neuroimmunol. 1998, 81 (1-2), 201-210.
30. Scott, G.S.; Williams, K.I.; Bolton, C. A pharmacological study on the role of nitric oxide in the pathogenesis of experimental allergic encephalomyelitis. Inflamm. Res. 1996, 45 (10), 524-529.
31. Ruuls, S.R.; Van der Linden, S.; Sontrop, K.; Huitinga, I.; Dijkstra, C.D. Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors. Clin. Exp. Immunol. 1996, 103 (3), 467-474.
32. Kubes, P.; Suzuki, M.; Granger, D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl Acad. Sci. USA 1991, 88 (11), 4651-4655.
33. Bebo, B.F., Jr.; Yong, T.; Orr, E.L.; Linthicum, D.S. Hypothesis: a possible role for mast cells and their inflammatory mediators in the pathogenesis of autoimmune encephalomyelitis. J. Neurosci Res. 1996, 45 (4), 340-348.
34. Kwak, H.J.; Yang, Y.S.; Pae, H.O.; Kim, Y.M.; Chung, H.T. Exogenous nitric oxide inhibits experimental autoimmune uveoretinitis development in Lewis rats by modulation of the Th1-dependent immune response. Mol. Cells 2001, 12 (2), 178-184.