Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase

Journal of Neuroimmunology

Volumn 81, Issue 1-2, 1998, Pages 201-210

  Okuda, Yoshinobu ^a   Sakoda, Saburo ^a   Fujimura, Harutoshi ^a   Yanagihara, Takehiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Aminoguanidine; Experimental allergic encephalomyetitis; Nitric oxide

Indexed keywords

AMINOGUANIDINE;

ALLERGIC ENCEPHALITIS; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; ENZYME INDUCTION; ENZYME INHIBITION; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; AUTOIMMUNE DISEASES; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME INHIBITORS; FEMALE; GUANIDINES; IMMUNIZATION SCHEDULE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SEIZURES;

EID: 0031863349     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00180-X     Document Type: Article

References (38)

1. Albina J.E., Cui S., Mateo R.B., Reichner J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150:1993;5080-5085.
2. Brenner T., Brocke S., Szafer F., Sobel R.A., Parkinson J.F., Perez D.H., Steinman L. Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis. J. Immunol. 158:1997;2940-2946.
3. Buisson A., Lakhmeche N., Verrecchia C., Plotkine M., Boulu R.G. Nitric oxide: An endogenous anticonvulsant substance. Neuroreport. 4:1993;444-446.
4. Cross A.H., Misko T.P., Lin R.F., Hickey W.F., Trotter J.L., Tilton R.G. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93:1994;2684-2690.
5. Cross A.H., Keeling R.M., Goorha S., San M., Rodi C., Wyatt P.S., Manning P.T., Misko T.P. Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis. J. Neuroimmunol. 71:1996;145-153.
6. Denham S., Rowland I.J. Inhibition of reactive proliferation of lymphocytes by activated macrophages: The role of nitric oxide. Clin. Exp. Immunol. 87:1992;157-162.
7. Ding A.H., Nathan C.F., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 141:1988;2407-2412.
8. Drapier J.C., Wietzerbin J., Hibbs J.B. Jr. Interferon-γ and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur. J. Immunol. 18:1988;1587-1592.
9. Ferber I.A., Brocke S., Edwards C.T., Ridgway W., Dinisco C., Steinman L., Dalton D., Fathman C.G. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:1996;5-7.
10. Koprowski H., Zheng Y.M., Katz E.H., Fraser N., Rorke L., Fu Z.F., Hanlon C., Dietzschold B. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc. Natl. Acad. Sci. USA. 90:1993;3024-3027.
11. Kubes P., Suzuki M., Granger D.N. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA. 88:1991;4651-4655.
12. Lin R.F., Lin T.S., Tilton R.G., Cross A.H. Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: An electron paramagnetic resonance study. J. Exp. Med. 178:1993;643-648.
13. Maggio R., Fumagalli F., Donati E., Barbier P., Racagni G., Corsini G.U., Riva M. Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. Brain Res. 679:1995;184-187.
14. Merrill J.E., Ignarro L.J., Sherman M.P., Melinek J., Lane T.E. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:1993;2132-2141.
15. Mills C.D. Molecular basis of 'suppressor' macrophages. Arginine metabolism via the nitric oxide synthetase pathway. J. Immunol. 146:1991;2719-2723.
16. Misko T.P., Moore W.M., Kasten T.P., Nickols G.A., Corbett J.A., Tilton R.G., McDaniel M.L., Williamson J.R., Currie M.G. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:1993;119-125.
17. Mitrovic B., Ignarro L.J., Montestruque S., Smoll A., Merrill J.E. Nitric oxide as a potential pathological mechanism in demyelination: Its differential effects on primary glial cells in vitro. Neuroscience. 61:1994;575-585.
18. Mitrovic B., Ignarro L.J., Vinters H.V., Akers M.A., Schmid I., Uittenbogaart C., Merrill J.E. Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes. Neuroscience. 65:1995;531-539.
19. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1992;3051-3064.
20. Nguyen K.B., McCombe P.A., Pender M.P. Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. J. Autoimmun. 7:1994;145-152.
21. Okuda Y., Nakatsuji Y., Fujimura H., Esumi H., Ogura T., Yanagihara T., Sakoda S. Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis. J. Neuroimmunol. 62:1995;103-112.
22. Okuda Y., Sakoda S., Shimaoka M., Yanagihara T. Nitric oxide induces apoptosis in mouse splenic T-lymphocytes. Immunol. Lett. 52:1996;135-138.
23. Okuda Y., Sakoda S., Fujimura H., Yanagihara T. Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis. J. Neuroimmunol. 73:1997;107-116.
24. Pender M.P., Nguyen K.B., McCombe P.A., Kerr J.F.R. Apoptosis in the nervous system in experimental allergic encephalomyelitis. J. Neurol. Sci. 104:1991;81-87.
25. Przegalinski E., Baran L., Siwanowicz J. The role of nitric oxide in the kainate-induced seizures in mice. Neurosci. Lett. 170:1994;74-76.
26. Robinson A.W.T., Liew F.Y., Severn A., Xu D., McSorley S.J., Garside P., Padron J., Phillips R.S. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24:1994;980-984.
27. Ruuls S.R., Van der Linden S., Sontrop K., Huitinga I., Dijkstra C.D. Aggravation of experimental allergic encephalomyelitis (EAE) by administration of nitric oxide (NO) synthase inhibitors. Clin. Exp. Immunol. 103:1996;467-474.
28. Saeki Y., Mima T., Sakoda S., Fujimura H., Arita N., Nomura T., Kishimoto T. Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients. Proc. Natl. Acad. Sci. USA. 89:1992;6157-6161.
29. Sarih M., Souvannavong V., Adam A. Nitric oxide synthase induces macrophage death by apoptosis. Biochem. Biophys. Res. Commun. 191:1993;503-508.
30. Schmied M., Breitschopf H., Gold R., Zischler H., Rothe G., Wekerle H., Lassmann H. Apoptosis of T-lymphocytes in experimental autoimmune encephalomyelitis. Am. J. Pathol. 143:1993;446-452.
31. Sherman M.P., Griscavage J.M., Ignarro L.J. Nitric oxide-mediated neuronal injury in multiple sclerosis. Med. Hypotheses. 39:1992;143-146.
32. Shimaoka M., Iida T., Ohara A., Taenaka N., Mashimo T., Honda T., Yoshiya I. NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages. Biochem. Biophys. Res. Commun. 209:1995;519-526.
33. + encephalitogenic T-cells. Eur. J. Immunol. 24:1994;2609-2617.
34. Tabi Z., McCombe P.A., Pender M.P. Antigen-specific down-regulation of myelin basic protein-reactive T-cells during spontaneous recovery from experimental autoimmune encephalomyelitis: Further evidence of apoptotic deletion of autoreactive T-cells in the central nervous system. Int. Immunol. 7:1995;967-973.
35. Van Dam A.M., Bauer J., Man-A-Hing W.K.H., Marquette C., Tilders F.J.H., Berkenbosch F. Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin. J. Neurosci. Res. 40:1995;251-260.
36. Willenborg D.O., Fordham S., Bernard C.C.A., Cowden W.B., Ramshaw I.A. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157:1996;3223-3227.
37. Zhao W., Tilton R.G., Corbett J.A., McDaniel M.L., Misko T.P., Williamson J.R., Cross A.H., Hickey W.F. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. J. Neuroimmunol. 64:1996;123-133.
38. Zielasek J., Jung S., Gold R., Liew F.Y., Toyka K.V., Hartung H.P. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis. J. Neuroimmunol. 58:1995;81-88.