Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: Rapid induction of Th1-type cytokines and inducible nitric oxide synthase

Journal of Immunology

Volumn 165, Issue 12, 2000, Pages 7157-7163

  Weishaupt, A ^a   Jander, S ^a   Bruck, W ^a   Kuhlmann, T ^a   Stienekemeier, M ^a   Hartung, T ^a   Toyka, K V ^a   Stoll, G ^a   Gold, R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; INTERLEUKIN 10; MYELIN BASIC PROTEIN; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MEGADOSE; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL;

EID: 0034671635     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.12.7157     Document Type: Article

References (45)

1. The T lymphocyte in experimental allergic encephalomyelitis
2. Animal models for autoimmune demyelinating disorders of the nervous system
3. Analysis of autoimmune demyelination its impact upon multiple sclerosis
4. Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease
5. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
6. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
7. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
8. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
9. 1L-10 fails to abrogate experimental autoimmune encephalomyelitis
10. Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice
11. IL-10 is crucial in the regulation of autoimmune encephaloymyelitis as demonstrated by studies of IL-I0- and IL-4-deficient and transgenic mice
12. Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis
13. Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase
14. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene
15. Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase
16. Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis a review
17. Antigen-induced suppression of the proliferation response of T cell clones
18. Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression
19. Intravenous antigen administration as a therapy for autoimmune demyelinating disease
20. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
21. Antigen therapy eliminates T cell inflammation by apoptosis effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2
22. Systemic antigen in the treatment of T-cell-mediated autoimmune diseases
23. Amelioration of autoimmune reactions by antigen-induced apoptosis of T cells
24. Role of TNF-α in high-dose antigen therapy in experimental autoimmune neuritis inhibition of TNF-α by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis
25. Myelin basic proteins
26. Suppression of experimental autoimmune encephalomyelitis in Lewis rats by antibodies against CD2
27. T-cell receptor (TCR) usage in Lewis rat experimental autoimmune encephalomyelitis TCR β-chain-variable-region V β 8 2-positive T cells are not essential for induction and course of disease
28. Lipopolysaccharide-induced interleukin-10 in mice role of endogenous tumor necrosis factor-α
29. Endotoxin-inducible cytotoxicity in liver cell cultures-I
30. Time course and cellular localization of interleukin-10 mRNA and protein expression in autoimmune inflammation of the rat central nervous system
31. Differential induction of interleukin-12, interleukin-18, and interleukin-1β converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat
32. Intravenous glucocorticosteroid treatment augments apoptosis of inflammatory T cells in experimental autoimmune neuritis (EAN) of the Lewis rat
33. The demyelinating potential of antibodies to myelin oligidendrocyte glycoprotein is related to their ability to fix complement
34. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation technique
35. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice models for multiple sclerosis with primary oligodendrogliopathy
36. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
37. Interferon-γ confers resistance to experimental allergic encephalomyelitis
38. Induction of apoptosis in mature T cells by tumour necrosis factor
39. T-cell apoptosis in autoimmune diseases termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms
40. T-cell apoptosis in inflammatory brain lesions destruction of T cells does not depend on antigen recognition
41. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
42. Homing to central nervous system vasculature by antigen-specific lymphocytes
43. IFN-γ is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue a possible role for nitric oxide
44. Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis
45. Apoptosis of myelin-reactive T cells induced by reactive oxygen and nitrogen intermediates in vitro