메뉴 건너뛰기




Volumn 284, Issue 1 47-1, 2003, Pages

Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects

Author keywords

Acipimox; Hypertriglyceridemia; Insulin sensitivity; Lipotoxicity; Low fat diet

Indexed keywords

ACIPIMOX; FATTY ACID; HEPARIN; INSULIN; INTRALIPID;

EID: 0037225537     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00114.2002     Document Type: Article
Times cited : (21)

References (42)
  • 1
    • 0029838257 scopus 로고    scopus 로고
    • Very-long-chain n-3 fatty acids as biomarkers for intake of fish and n-3 fatty acid concentrates
    • Andersen LF, Solvoll K, and Drevon CA. Very-long-chain n-3 fatty acids as biomarkers for intake of fish and n-3 fatty acid concentrates. Am J Clin Nutr 64: 305-311, 1996.
    • (1996) Am J Clin Nutr , vol.64 , pp. 305-311
    • Andersen, L.F.1    Solvoll, K.2    Drevon, C.A.3
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Anonymous. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Anonymous. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285: 2486-2497, 2001.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10, 1997.
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 4
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Chen X, Rosner J, and Barton M. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44: 1239-1242, 1995.
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 5
    • 0025308724 scopus 로고
    • Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso study
    • Bonaa KH, Bjerve KS, Straume B, Gram IT, and Thelle D. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso study. N Engl J Med 322: 795-801, 1990.
    • (1990) N Engl J Med , vol.322 , pp. 795-801
    • Bonaa, K.H.1    Bjerve, K.S.2    Straume, B.3    Gram, I.T.4    Thelle, D.5
  • 6
    • 0034005968 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
    • Carpentier A, Mittelman SD, Bergman RN, Giacca A, and Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes 49: 399-408, 2000.
    • (2000) Diabetes , vol.49 , pp. 399-408
    • Carpentier, A.1    Mittelman, S.D.2    Bergman, R.N.3    Giacca, A.4    Lewis, G.F.5
  • 8
    • 0030759095 scopus 로고    scopus 로고
    • The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: Results of the Paris Prospective Study
    • Charles MA, Eschwege E, Thibult N, Claude JR, Warnet JM, Rosselin GE, Girard J, and Balkau B. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: Results of the Paris Prospective Study. Diabetologia 40: 1101-1106, 1997.
    • (1997) Diabetologia , vol.40 , pp. 1101-1106
    • Charles, M.A.1    Eschwege, E.2    Thibult, N.3    Claude, J.R.4    Warnet, J.M.5    Rosselin, G.E.6    Girard, J.7    Balkau, B.8
  • 9
    • 0034526516 scopus 로고    scopus 로고
    • Cardiovascular disease and risk factors in persons with type 2 diabetes diagnosed in a large population screening: The Nord-Trondelag Diabetes Study, Norway
    • Claudi T, Midthjell K, Holmen J, Fougner K, Kruger O, and Wiseth R. Cardiovascular disease and risk factors in persons with type 2 diabetes diagnosed in a large population screening: The Nord-Trondelag Diabetes Study, Norway. J Intern Med 248: 492-500, 2000.
    • (2000) J Intern Med , vol.248 , pp. 492-500
    • Claudi, T.1    Midthjell, K.2    Holmen, J.3    Fougner, K.4    Kruger, O.5    Wiseth, R.6
  • 12
    • 0023917295 scopus 로고
    • Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus
    • Glauber H, Wallace P, Griver K, and Brechtel G. Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. Ann Intern Med 108: 663-668, 1988.
    • (1988) Ann Intern Med , vol.108 , pp. 663-668
    • Glauber, H.1    Wallace, P.2    Griver, K.3    Brechtel, G.4
  • 13
    • 0033038329 scopus 로고    scopus 로고
    • Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: The Insulin Resistance Atherosclerosis Study
    • Haffner SM, D'Agostino R Jr, Mykkanen L, Tracy R, Howard B, Rewers M, Selby J, Savage PJ, and Saad MF. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: The Insulin Resistance Atherosclerosis Study. Diabetes Care 22: 562-568, 1999.
    • (1999) Diabetes Care , vol.22 , pp. 562-568
    • Haffner, S.M.1    D'Agostino R., Jr.2    Mykkanen, L.3    Tracy, R.4    Howard, B.5    Rewers, M.6    Selby, J.7    Savage, P.J.8    Saad, M.F.9
  • 16
    • 0034945695 scopus 로고    scopus 로고
    • Diet and risk of type II diabetes: The role of types of fat and carbohydrate
    • Hu FB, van Dam RM, and Liu S. Diet and risk of type II diabetes: The role of types of fat and carbohydrate. Diabetologia 44: 805-817, 2001.
    • (2001) Diabetologia , vol.44 , pp. 805-817
    • Hu, F.B.1    Van Dam, R.M.2    Liu, S.3
  • 17
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: A reexamination
    • Kelley DE and Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: A reexamination. Diabetes 49: 677-683, 2000.
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 18
    • 0023161988 scopus 로고
    • Nutritional behavior of non-insulin-dependent type II diabetes patients using the KALI 2.12 computer program
    • Matzkies F, Webs B, Rusche R, and Dirks K. [Nutritional behavior of non-insulin-dependent type II diabetes patients using the KALI 2.12 computer program]. Z Ernahrungswiss 26: 84-99, 1987.
    • (1987) Z Ernahrungswiss , vol.26 , pp. 84-99
    • Matzkies, F.1    Webs, B.2    Rusche, R.3    Dirks, K.4
  • 19
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • McGarry JD and Dobbins RL. Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42: 128-138, 1999.
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 21
    • 0034853053 scopus 로고    scopus 로고
    • The pathophysiology of type 2 diabetes mellitus: An overview
    • Ostenson CG. The pathophysiology of type 2 diabetes mellitus: An overview. Acta Physiol Scand 171: 241-247, 2001.
    • (2001) Acta Physiol Scand , vol.171 , pp. 241-247
    • Ostenson, C.G.1
  • 24
    • 0029049346 scopus 로고
    • A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM
    • Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, and Ravussin E. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38: 1213-1217, 1995.
    • (1995) Diabetologia , vol.38 , pp. 1213-1217
    • Paolisso, G.1    Tataranni, P.A.2    Foley, J.E.3    Bogardus, C.4    Howard, B.V.5    Ravussin, E.6
  • 25
    • 0030045492 scopus 로고    scopus 로고
    • Effects of an acute decrease in non-esterified fatty acid levels on muscle glucose utilization and forearm indirect calorimetry in lean NIDDM patients
    • Piatti PM, Monti LD, Davis SN, Conti M, Brown MD, Pozza G, and Alberti KG. Effects of an acute decrease in non-esterified fatty acid levels on muscle glucose utilization and forearm indirect calorimetry in lean NIDDM patients. Diabetologia 39: 103-112, 1996.
    • (1996) Diabetologia , vol.39 , pp. 103-112
    • Piatti, P.M.1    Monti, L.D.2    Davis, S.N.3    Conti, M.4    Brown, M.D.5    Pozza, G.6    Alberti, K.G.7
  • 26
    • 0036316753 scopus 로고    scopus 로고
    • Effects of long term fasting on insulin responses to fatty acids in man
    • Qvigstad E, Bjerve KS, and Grill V. Effects of long term fasting on insulin responses to fatty acids in man. Scand J Clin Lab Invest 62: 271-278, 2002.
    • (2002) Scand J Clin Lab Invest , vol.62 , pp. 271-278
    • Qvigstad, E.1    Bjerve, K.S.2    Grill, V.3
  • 27
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle PJ. Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283, 1998.
    • (1998) Diabetes Metab Rev , vol.14 , pp. 263-283
    • Randle, P.J.1
  • 28
    • 0023734690 scopus 로고
    • Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
    • Randle PJ, Kerbey AL, and Espinal J. Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones. Diabetes Metab Rev 4: 623-638, 1988.
    • (1988) Diabetes Metab Rev , vol.4 , pp. 623-638
    • Randle, P.J.1    Kerbey, A.L.2    Espinal, J.3
  • 30
    • 0024995157 scopus 로고
    • A 48-h lipid infusion in the rat timedependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y and Grill VE. A 48-h lipid infusion in the rat timedependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127: 1580-1589, 1990.
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 31
    • 0027491783 scopus 로고
    • Different acute and chronic effects of acipimox treatment on glucose and lipid metabolism in patients with type 2 diabetes
    • Saloranta C, Groop L, Ekstrand A, Franssila-Kallunki A, Eriksson J, and Taskinen MR. Different acute and chronic effects of acipimox treatment on glucose and lipid metabolism in patients with type 2 diabetes. Diabet Med 10: 950-957, 1993.
    • (1993) Diabet Med , vol.10 , pp. 950-957
    • Saloranta, C.1    Groop, L.2    Ekstrand, A.3    Franssila-Kallunki, A.4    Eriksson, J.5    Taskinen, M.R.6
  • 32
    • 0030803886 scopus 로고    scopus 로고
    • Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control
    • Shih KC, Kwok CF, Hwu CM, Hsiao LC, Li SH, Liu YF, and Ho LT. Acipimox attenuates hypertriglyceridemia in dyslipidemic noninsulin dependent diabetes mellitus patients without perturbation of insulin sensitivity and glycemic control. Diabetes Res Clin Pract 36: 113-119, 1997.
    • (1997) Diabetes Res Clin Pract , vol.36 , pp. 113-119
    • Shih, K.C.1    Kwok, C.F.2    Hwu, C.M.3    Hsiao, L.C.4    Li, S.H.5    Liu, Y.F.6    Ho, L.T.7
  • 33
    • 0035032780 scopus 로고    scopus 로고
    • Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptorgamma 2 gene
    • Stefan N, Fritsche A, Haring H, and Stumvoll M. Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptorgamma2 gene. Diabetes 50: 1143-1148, 2001.
    • (2001) Diabetes , vol.50 , pp. 1143-1148
    • Stefan, N.1    Fritsche, A.2    Haring, H.3    Stumvoll, M.4
  • 34
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: A progressive disease. UK Prospective Diabetes Study 16
    • UK Prospective Diabetes Study Group. Overview of 6 years' therapy of type II diabetes: A progressive disease. UK Prospective Diabetes Study 16. Diabetes 44: 1249-1258, 1995.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 35
    • 0028221978 scopus 로고
    • Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells
    • Warnotte C, Gilon P, Nenquin M, and Henquin JC. Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes 43: 703-711, 1994.
    • (1994) Diabetes , vol.43 , pp. 703-711
    • Warnotte, C.1    Gilon, P.2    Nenquin, M.3    Henquin, J.C.4
  • 37
    • 0031882141 scopus 로고    scopus 로고
    • Metabolic interactions between glucose and fatty acids in humans
    • Wolfe RR. Metabolic interactions between glucose and fatty acids in humans. Am J Clin Nutr 67: 519S-526S, 1998.
    • (1998) Am J Clin Nutr , vol.67
    • Wolfe, R.R.1
  • 38
    • 0027319705 scopus 로고
    • Analysis of techniques to obtain plasma for measurement of levels of free fatty acids
    • Zambon A, Hashimoto SI, and Brunzell JD. Analysis of techniques to obtain plasma for measurement of levels of free fatty acids. J Lipid Res 34: 1021-1028, 1993.
    • (1993) J Lipid Res , vol.34 , pp. 1021-1028
    • Zambon, A.1    Hashimoto, S.I.2    Brunzell, J.D.3
  • 39
    • 0029983884 scopus 로고    scopus 로고
    • A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse
    • Zhou YP, Berggren PO, and Grill V. A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse. Diabetes 45: 580-586, 1996.
    • (1996) Diabetes , vol.45 , pp. 580-586
    • Zhou, Y.P.1    Berggren, P.O.2    Grill, V.3
  • 40
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP and Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870-876, 1994.
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 41
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP and Grill V. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80: 1584-1590, 1995.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 42
    • 0028988135 scopus 로고
    • Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets
    • Zhou YP and Grill VE. Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44: 394-399, 1995.
    • (1995) Diabetes , vol.44 , pp. 394-399
    • Zhou, Y.P.1    Grill, V.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.