In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex

Journal of Bacteriology

Volumn 182, Issue 11, 2000, Pages 3158-3164

  Messenguy, Francine ^a,b   Vierendeels, Fabienne ^a   Scherens, Bart ^a   Dubois, Evelyne ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b Inst Rech Microbiologiques J M   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; ARGININE;

AMINO ACID METABOLISM; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; ENZYME ANALYSIS; GENE EXPRESSION SYSTEM; GENE SEQUENCE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ARGINASE; ARGININE; BACTERIAL PROTEINS; DNA-BINDING PROTEINS; ENZYME INDUCTION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, FUNGAL; HISTONE DEACETYLASES; MCM1 PROTEIN; MEMBRANE PROTEINS; NITROGEN; ORNITHINE-OXO-ACID TRANSAMINASE; PROTEIN BINDING; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0034127687     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.11.3158-3164.2000     Document Type: Article

References (47)

1. Béchet, J., M. Grenson, and J. M. Wiame. 1970. Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae. Eur. J. Biochem. 12:31-39.
2. Bidlingmeyer, B. A., S. A. Cohen, and T. L. Tarvin. 1984. Rapid analysis of amino acids using pre-column derivatization. J. Chromatogr. 336:93-104.
3. Brachmann, C. B., A. Davits, G. J. Cost, E. Caputo, J. Li, P. Hieter, and J. D. Boeke. 1998. Designer deletion strains derived from S. cerevisiae S288c: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14:115-132.
4. Candau, R., J. X. Zhou, C. D. Allis, and S. L. Berger. 1997. Histone acetyltransferase activity and interaction with Ada2 are critical for Gcn5 function in vivo. EMBO J. 16:555-565.
5. Casadaban, M. J., J. Chou, and S. Cohen. 1980. In vitro gene fusions that join an enzymatically active β-galactosidase segment to amino-terminal fragments of exogenous proteins: E. coli plasmid vectors for the detection and cloning of translation initiation signals. J. Bacteriol. 143:971-980.
6. Courchesne, W. E. 1985. Nitrogen regulation in S. cerevisiae. Ph.D. thesis. Massachusetts Institute of Technology, Cambridge.
7. Deschamps, J., E. Dubois, and J. M. Wiame. 1979. L-Ornithine transaminase synthesis in Saccharomyces cerevisiae: regulation by inducer exclusion. Mol. Gen. Genet. 174:225-232.
8. Dubois, E., M. Grenson, and J. M. Wiame. 1974. The participation of the anabolic glutamate dehydrogenase in the nitrogen catabolite repression of arginase in Saccharomyces cerevisiae. Eur. J. Biochem. 48:603-616.
9. Dubois, E., D. Hiernaux, M. Grenson, and J. M. Wiame. 1978. Specific induction of catabolism and its relation to repression of biosynthesis in the arginine metabolism of Saccharomyces cerevisiae. J. Mol. Biol. 122:383-406.
10. Dubois, E., and F. Messenguy. 1991. In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter. Mol. Cell. Biol. 11:2162-2168.
11. Dubois, E., and F. Messenguy. 1997. Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: role of Gln3p, ArgRp-Mcm1p and Ume6p. Mol. Gen. Genet. 253:568-580.
12. Dubois, E., F. Vierendeels, and F. Messenguy. 1999. Role of histone deacetylase Rpd3 in the control of expression of arginine catabolic genes. Curr. Genet. 35:243.
13. Durfee, T., K. Becherer, R.-L. Chen, S. H. Yeh, Y. Yang, A. E. Kilburn, W. H. Lee, and S. J. Elledge. 1993. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7:555-569.
14. El Bakkoury, M., E. Dubois, and F. Messenguy. 2000. Recruitment of the yeast MADS-box proteins, ArgRI and Mcm1, by the pleiotropic factor ArgRIII is required for their stability. Mol. Microbiol. 35:15-31.
15. Georgakopoulos, T., N. Gounalaki, and G. Thireos. 1995. Genetic evidence for the interaction of the yeast transcriptional co-activator proteins Gcn5 and Ada2. Mol. Gen. Genet. 246:723-728.
16. Guldener, U., S. Heck, T. Fiedler, J. Beinhauwer, and J. H. Hegemann. 1996. A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 24:2519-2524.
17. Hennaut, C. 1981. Ornithine transaminase synthesis in Saccharomyces cerevisiae: induction by allophanate, intermediate and inducer of the urea degradative pathway, adds to arginine induction. Curr. Genet. 4:69-72.
18. Holstege, F. C., E. G. Jennings, J. J. Wyrick, T. I. Lee, C. J. Hengartner, M. R. Green, T. R. Golub, E. S. Lander, and R. A. Young. 1998. Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717-728.
19. Ito, H., Y. Fukura, K. Murata, and A. Timura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
20. Kadosh, D., and K. Struhl. 1997. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89:365-371.
21. Kitamoto, K., K. Yoshizawa, Y. Ohsumi, and Y. Anraku. 1988. Dynamic aspects of vacuolar and cytosolic amino acid pools of Saccharomyces cerevisiae. J. Bacteriol. 170:2683-2686.
22. Louvet, O., F. Doignon, and M. Crouzet. 1997. Stable DNA-binding yeast vector allowing high-bait expression for use in the two-hybrid system. Bio-Techniques 23:816-817.
23. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
24. Luche, R. M., R. Sumrada, and T. G. Cooper. 1990. A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CAR1 gene. Mol. Cell. Biol. 10:3884-3895.
25. Malathi, K., Y. Xiao, and A. P. Mitchell. 1997. Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol. Cell. Biol. 17:7230-7236.
26. Marcus, G. A., N. Silverman, S. L. Berger, J. Horiuchi, and L. Guarente. 1994. Functional similarity and physical association between Gcn5 and Ada2: putative transcriptional adaptors. EMBO J. 13:4807-4815.
27. Messenguy, F. 1976. Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant constitutive mutant for ornithine carbamoyltransferase synthesis. J. Bacteriol. 128:49-55.
28. Messenguy, F., and E. Dubois. 1993. Genetic evidence for a role for Mcm1 in the regulation of arginine metabolism in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:2586-2592.
29. Messenguy, F., E. Dubois, and C. Boonchird. 1991. Determination of the DNA binding sequences of ARGR proteins to arginine anabolic and catabolic promoters. Mol. Cell. Biol. 11:2852-2863.
30. Messenguy, F., M. Penninckx, and J.-M. Wiame. 1971. Interaction between arginase and ornithine carbamoyltransferase in Saccharomyces cerevisiae. Eur. J. Biochem. 22:277-286.
31. Miller, J. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
32. II250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
33. Ohsumi, Y., K. Kitamoto, and Y. Anraku. 1988. Changes induced in the permeability barrier of the yeast plasma membrane by cupric ion. J. Bacteriol. 170:2676-2682.
34. Park, H.-D., R. M. Luche, and T. G. Cooper. 1992. The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site. Nucleic Acids Res. 20:1909-1915.
35. Park, H.-D., S. Scott, R. Rai, R. Dorrington, and T. G. Cooper. 1999. Synergistic operation of the CAR2 (ornithine transaminase) promoter elements in Saccharomyces cerevisiae. J. Bacteriol. 181:7052-7064.
36. Rothstein, R. J. 1991. Targeting, disruption, replacement and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-301.
37. Rubin-Bejerano, I., S. Mandel, K. Robzyk, and Y. Kassir. 1996. Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional repressor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. Mol. Cell. Biol. 16:2518-2526.
38. Rundlett, S. E., A. A. Carmen, R. Kobayashi, S. Bavykin, B. M. Turner, and M. Grunstein. 1996. Hda1 and Rpd3 are members of distinct yeast histone deacetylase complexes. Proc. Natl. Acad. Sci. USA 93:14503-14508.
39. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in S. cerevisiae. Genetics 122:19-27.
40. Smart, W. C., J. A. Coffman, and T. G. Cooper. 1996. Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) gene promoter in response to multiple environmental signals. Mol. Cell. Biol. 16:5876-5887.
41. Strich, R., R. T. Surosky, C. Steber, E. Dubois, F. Messenguy, and R. E. Esposito. 1994. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 8:796-810.
42. Thuriaux, P. 1969. Ph.D. thesis. Brussels University, Brussels, Belgium.
43. Vidal, M., and R. F. Gaber. 1991. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:6317-6327.
44. Vidal, M., R. Strich, R. E. Esposito, and R. F. Gaber. 1991. RPD1 (SIN3/ UME4) is required for maximal activation and repression of diverse yeast genes. Mol. Cell. Biol. 11:6306-6316.
45. Wach, A. 1996. PCR-synthesis of marker cassettes with long flanking homology regions for gene disruptions in Saccharomyces cerevisiae. Yeast 12:259-265.
46. Withney, P. A., and B. Magasanik. 1973. The induction of arginase in Saccharomyces cerevisiae. J. Biol. Chem. 248:6197-6202.
47. Zhang, Y., Z.-W. Sun, R. Iratni, H. Erdjument-Bromage, P. Tempst, M. Hampsey, and D. Reinberg. 1998. Sap30, a novel protein conserved between human and yeast, is a component of an histone deacetylase complex. Mol. Cell 1:1021-1031.