Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization

Current Biology

Volumn 11, Issue 19, 2001, Pages 1536-1541

  Palazzo, Alexander F ^a   Joseph, Hazel L ^a,b   Chen, Ying Jiun ^a   Dujardin, Denis L ^c   Alberts, Arthur S ^d   Pfister, K Kevin ^e   Vallee, Richard B ^c   Gundersen, Gregg G ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d VAN ANDEL INSTITUTE   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035797905     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00475-4     Document Type: Article

References (35)

1. Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound
2. Distribution of microtubule organizing centers in migrating sheets of endothelial cells
3. Selective stabilization of microtubules oriented toward the direction of cell migration
4. Centrosome positioning and directionality of cell movements
5. Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid
6. mDia mediates Rho regulated formation and orientation of stable microtubules
7. Induction of stable microtubules in 3T3 fibroblasts by TGF-beta and serum
8. Two effects of lysophosphatidic acid on Ca(2+)-movement in cultured bovine adrenal chromaffin cells
9. Depletion of lysophosphatidic acid triggers a loss of oriented detyrosinated microtubules in motile fibroblasts
10. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
11. Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading
12. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
13. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
14. Distribution of detyrosinated microtubules in motile NRK fibroblasts is rapidly altered upon cell-cell contact: Implications for contact inhibition of locomotion
15. Microtubule-organizing centers and cell migration: Effect of inhibition of migration and microtubule disruption in endothelial cells
16. Reorientation of the Golgi apparatus and the microtubule-organizing center inside macrophages subjected to a chemotactic gradient
17. Effects of cytochalasin and phalloidin on actin
18. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex
19. Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae
20. The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryos
21. A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function
22. Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion
23. Dynein- and microtubule-mediated translocation of adenovirus serotype 5 occurs after endosomal lysis
24. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
25. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution
26. Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo
27. Identification of a carboxy-terminal diaphanous-related formin homology protein autoregulatory domain
28. Rho GTPases control polarity, protrusion, and adhesion during cell movement
29. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42
30. Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells
31. Colocalization of cytoplasmic dynein with dynactin and CUP-170 at microtubule distal ends
32. Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap
33. Membrane insertion at the leading edge of motile fibroblasts
34. Kinesin is a candidate for cross-bridging microtubules and intermediate filaments. Selective binding of kinesin to detyrosinated tubulin and vimentin
35. Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles