Axis determination in C. elegans: Initiating and transducing polarity

Current Opinion in Genetics and Development

Volumn 11, Issue 4, 2001, Pages 367-373

  Gotta, Monica ^a   Ahringer, Julie ^a  

^a WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; MATERNAL PROTEIN; PARTIONING DEFECTIVE PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANTERIOR POSTERIOR AXIS; BLASTOMERE; CAENORHABDITIS ELEGANS; CELL POLARITY; EMBRYO DEVELOPMENT; MEIOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN LOCALIZATION; REVIEW; SPERM; SPERMATOZOON PENETRATION;

EID: 0035427318     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00206-9     Document Type: Review

References (60)

1. Fertilization and establishment of polarity in the embryo
2. Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans
3. Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos
4. An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes
5. Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo
6. Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans
7. Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans
8. PAR-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
9. PAR-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs
10. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos
11. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos
12. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
13. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
14. PARsing embryonic polarity
15. Specification of the anteroposterior axis in Caenorhabditis elegans
16. Anucleate Caenorhabditis elegans sperm can crawl, fertilize oocytes and direct anterior-posterior polarization of the 1-cell embryo
17. The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote
18. Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process
19. Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans
20. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
21. A Drosophila melanogaster homologue of Caenorhabditis elegans PAR-1 acts at an early step in embryonic-axis formation
22. The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis
23. CDC-42 controls early polarity and spindle orientation in C. elegans
24. CDC-42 regulates PAR protein localisation and function to control cellular and embryonic polarity in the C. elegans embryo
25. The cell-polarity protein PAR6 links PAR3 and atypical protein kinase C to CDC42
26. A mammalian PAR-3-PAR-6 complex implicated in CDC42/Rac1 and aPKC signalling and cell polarity
27. A human homolog of the C. elegans polarity determinant PAR-6 links Rac and CDC42 to PKCζ signaling and cell transformation
28. PAR-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3
29. CDC42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
30. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium
31. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
32. Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo
33. The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans
34. Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo
35. Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos
36. OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos
37. MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos
38. The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/Mapk signaling
39. The PIE-1 protein and germline specification in C. elegans embryos
40. Pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans
41. The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component
42. Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains
43. Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo
44. G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos
45. Distinct roles for G alpha and G betagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos
46. G protein beta1gamma2 subunits promote microtubule assembly
47. The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
48. A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans
49. Receptor-independent activators of heterotrimeric G-protein signaling pathways
50. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
51. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
52. A protein complex containing inscuteable and the G alpha-binding protein pins orients asymmetric cell divisions in Drosophila
53. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans
54. Mutations in the PAR genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle
55. Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis
56. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
57. RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans
58. Roles for 147 embryonic lethal genes on C. elegans Chromosome I identified by RNA interference and video-microscopy
59. Asymmetric cell division: Fly neuroblast meets worm zygote
60. Meiotic maturation induces animal-vegetal asymmetric distribution of aPKC and ASIP/PAR-3 in Xenopus oocytes