Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families

American Journal of Human Genetics

Volumn 72, Issue 1, 2003, Pages 168-177

  Laivuori, Hannele ^a,d,g   Lahermo, Päivi ^b   Ollikainen, Vesa ^b   Widen, Elisabeth ^b   Häivä Mällinen, Leena ^e   Sundström, Helena ^e,f   Laitinen, Tarja ^c   Kaaja, Risto ^a   Ylikorkala, Olavi ^a   Kere, Juha ^b,c,g  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e KAINUU CENTRAL HOSPITAL   (Finland)

^f JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^g KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUSTRALIA; CHINA; CHROMOSOME 2P; CHROMOSOME 4Q; CHROMOSOME 9P; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FINLAND; GENE LOCUS; GENE MAPPING; GENETIC HETEROGENEITY; GENETIC LINKAGE; HUMAN; HYPOTHESIS; ICELAND; NEW ZEALAND; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION; PREECLAMPSIA; PRIORITY JOURNAL; PUBLICATION; STUDY;

EID: 0037219649     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/345311     Document Type: Article

References (38)

1. Arngrimsson R, Bjornsson S, Geirsson RT, Bjornsson H, Walker JJ, Snaedal G (1990) Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol 97:762-769
2. Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston WA, Bjarnadottir RI, Brock DJ, Geirsson RT, Connor JM, Soubrier F, Broughton Pipkin F (1997) Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. Am J Hum Genet 61:354-362
3. Bailey JA, Gu Z, Clark RA, Reinert K, Samonte RV, Schwartz S, Adams MD, Myers EW, Li PW, Eichler EE (2002) Recent segmental duplications in the human genome. Science 297:1003-1007
4. Arngrimsson R, Purandare S, Connor M, Walker JJ, Bjornsson S, Soubrier F, Kotelevtsev YV, Geirsson RT, Bjornsson H (1993) Angiotensinogen: A candidate gene involved in pre-eclampsia? Nat Genet 4:114-115
5. Arngrimsson R, Sigurardottir S, Frigge ML, Bjarnadottir RI, Jonsson T, Stefansson H, Baldursdottir A, Einarsdottir AS, Palsson B, Snorradottir S, Lachmeijer AM, Nicolae D, Kong A, Bragason BT, Gulcher JR, Geirsson RT, Stefansson K (1999) A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 8:1799-1805
6. Arya R, Duggirala R, Almasy L, Rainwater DL, Mahaney MC, Cole S, Dyer TD, Williams K, Leach RJ, Hixson JE, MacCluer JW, O'Connell P, Stern MP, Blangero J (2002) Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans. Nat Genet 30:102-105
7. Broughton Pipkin F (1999) What is the place of genetics in the pathogenesis of pre-eclampsia? Biol Neonate 76:325-330
8. Chesley LC, Cooper DW (1986) Genetics of hypertension in pregnancy: Possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br J Obstet Gynaecol 93:898-908
9. de la Chapelle A, Wright FA (1998) Linkage disequilibrium mapping in isolated populations: The example of Finland revisited. Proc Natl Acad Sci USA 95:12416-12423
10. Esplin MS, Fausett MB, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW (2001) Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med 344:867-872
11. Guo G, Wilton AN, Fu Y, Qiu H, Brennecke SP, Cooper DW (1997) Angiotensinogen gene variation in a population case-control study of preeclampsia/eclampsia in Australians and Chinese. Electrophoresis 18:1646-1649
12. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakis G, Kaye JA, Turner RJ, Grehan M, Wilton AN, Brennecke SP, Cooper DW, Broughton Pipkin F (1997) A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am J Hum Genet 60:1158-1167
13. Hayward C, Livingstone J, Holloway S, Liston WA, Brock DJ (1992) An exclusion map for pre-eclampsia: Assuming autosomal recessive inheritance. Am J Hum Genet 50:749-757
14. Jonsdottir LS, Arngrimsson R, Geirsson RT, Sigvaldason H, Sigfusson N (1995) Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand 74:772-776
15. Kaaja R, Laivuori H, Laakso M, Tikkanen MJ, Ylikorkala O (1999) Evidence of a state of increased insulin resistance in preeclampsia. Metab Clin Exp 48:892-896
16. Kere J (2001) Human population genetics: Lessons from Finland. Annu Rev Genomics Hum Genet 2:103-128
17. Kere J, Elomaa O (2002) Healing a natural knockout of epithelial organogenesis. Trends Mol Med 8:197-200
18. Kong A, Gudbjatsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallback B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K (2002) A high-resolution recombination map of the human genome. Nat Genet 31:241-247
19. Lachmeijer AM, Arngrimsson R, Bastiaans EJ, Frigge ML, Pals G, Sigurdardottir S, Stefansson H, Palsson B, Nicolae D, Kong A, Aarnoudse JG, Gulcher JR, Dekker GA, ten Kate LP, Stefansson K (2001) A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 9:758-764
20. Laitinen T, Daly MJ, Rioux JD, Kauppi P, Laprise C, Petäys T, Green T, Cargill M, Haahtela T, Lander ES, Laitinen LA, Hudson TJ, Kere J (2001) A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet 28:87-91
21. Laivuori H, Kaaja R, Ylikorkala O, Hiltunen T, Kontula K (2000) 677 C→T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstet Gynecol 96:277-280
22. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
23. Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM (1998) Fetal and maternal contributions to risk of pre-eclampsia: Population based study. BMJ 316:1343-1347
24. Lindgren CM, Mahtani MM, Widen E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES (2002) Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: The Botnia study. Am J Hum Genet 70:509-516
25. Luo TH, Zhao Y, Li G, Yuan WT, Zhao JJ, Chen JL, Huang W, Luo M (2001) A genome-wide search for type II diabetes susceptibility genes in Chinese Hans. Diabetologia 44:501-506
26. Moses EK, Lade JA, Guo G, Wilton AN, Grehan M, Freed K, Borg A, Terwilliger JD, North R, Cooper DW, Brennecke SP (2000) A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 67:1581-1585
27. Ness RB, Roberts JM (1996) Heterogeneous causes constituting the single syndrome of preeclampsia: A hypothesis and its implications. Am J Obstet Gynecol 175:1365-1370
28. O'Shaughnessy KM, Fu B, Ferraro F, Lewis I, Downing S, Morris NH (1999) Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 33:1338-1341
29. Peltonen L, Jalanko A, Varilo T, Macdonald AM (1999) Molecular genetics of the Finnish disease heritage. Hum Mol Genet 8:1913-1923
30. Peltonen L, Palotie A, Lange K (2000) Use of population isolates for mapping complex traits. Nat Rev Genet 1:182-190
31. Powers RW, Minich LA, Lykins DL, Ness RB, Crombleholme WR, Roberts JM (1999) Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Investig 6:74-79
32. Roberts JM, Cooper DW (2001) Pathogenesis and genetics of pre-eclampsia. Lancet 357:53-56
33. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK (1989) Preeclampsia: An endothelial cell disorder. Am J Obstet Gynecol 161:1200-1204
34. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T, Morris NH (1997) Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 34:525-526
35. Thornton JG, Macdonald AM (1999) Twin mothers, pregnancy hypertension and pre-eclampsia. Br J Obstet Gynaecol 106:570-575
36. Treloar SA, Cooper DW, Brennecke SP, Grehan MMR, Martin NG (2001) An Australian twin study of the genetic basis of preeclampsia and eclampsia. Am J Obstet Gynecol 184:374-381
37. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, Ogasawara M, Suzumori K, Tomoda S, Berrebi S, Sasaki M, Corvol P, Lifton RP, Lalouel JM (1993) A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 4:59-61
38. Watanabe H, Hamada H, Yamakawa-Kobayashi K, Yoshikawa H, Arinami T, Guo G, Wilton AN, Fu Y, Qiu H, Brennecke SP, Cooper DW (2001) Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes. Thromb Haemost 86:1594-1595