Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region

American Journal of Human Genetics

Volumn 61, Issue 2, 1997, Pages 354-362

  Arngrímsson, Reynir ^a,b   Hayward, Caroline ^c   Nadaud, Sophie ^e   Baldursdóttir, Ásdis ^b   Walker, James J ^f   Liston, Wang A ^d   Bjarnadóttir, Ragnheidur I ^b   Brock, David J H ^c   Geirsson, Reynir T ^b   Connor, J Michael ^a   Soubrier, Florent ^e  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d Simpson Memorial Hospital   (United Kingdom)

^e SAINT LOUIS HOSPITAL   (France)

^f ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NITRIC OXIDE SYNTHASE; PROTEIN;

ALLELE; ARTICLE; BLOOD PRESSURE; CHROMOSOME 7Q; ENDOTHELIUM CELL; FAMILIAL DISEASE; FEMALE; GENE; GENETIC LINKAGE; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; PEDIGREE; PRIORITY JOURNAL; PROTEINURIA;

EID: 16944362319     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/514843     Document Type: Article

References (44)

1. Arngrímsson R, Björnsson H, Geirsson RT (1995) Analysis of different inheritance patterns in preeclampsia/eclampsia syndrome. Hypertens Pregnancy 14:27-38
2. Arngrímsson R, Björnsson S, Geirsson RT, Björnsson H, Walker JJ Snaedal G (1990) Familial and genetic predisposition to eclampsia and preeclampsia in a defined island population. Br J Obstet Gynaecol 97:762-770
3. Arngrímsson R, Geirsson RT, Cooke A, Connor JM, Björnsson S, Walker JJ (1994) Renin gene restriction fragment length polymorphisms do not show linkage with preeclampsia and eclampsia. Acta Obstet Gynecol Scand 73:10-13
4. Arngrímsson R, Purandare S, Connor JM, Walker JJ, Björnsson S, Geirsson RT, Björnsson H (1993) Angiotensinogen: a candidate gene involved in preeclampsia? Nat Genet 4: 114-115
5. Baker PN, Davidge ST, Roberts JM (1995) Plasma from women with preeclampsia increases endothelial cell nitric oxide production. Hypertension 26:244-248
6. Blackwelder WC, Elston RC (1985) A comparison of sibpair linkage test for disease susceptibility loci. Genet Epidemiol 2:83-97
7. Browne FJ, Sheumack DR (1956) Chronic hypertension following pre-eclamptic toxaemia: the influence of familial hypertension on its causation. J Obstet Gynaecol Br Commonw 63:677-680
8. Chesley LC, Cooper DW (1986) Genetics of hypertension in pregnancy: possible single gene control of preeclampsia and eclampsia. Am J Obstet Gynecol 53:851-863
9. Cooper DW, Liston WA (1979) Genetic control of severe pre-eclampsia. J Med Genet 16:409-416
10. Cottingham RW Jr, Idury RM, Schäffer AA (1993) Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263
11. Delacretaz E, De Quy N, Weber B, Vial Y, Shulz PE, Burnier M, Brunner HR, et al (1995) Differential nitric oxide synthase activity in human platelets during pregnancy and pre-eclampsia. Clin Sci 88:607-610
12. Durner M, Greenberg DA (1992) Effect of heterogeneity and assumed mode of inheritance on lod scores. Am J Med Genet 42:271-275
13. Gant NF, Daley GL, Chand S, Whalley PJ, MacDonald PC (1973) A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest 52:2682-2689
14. Goetz RM, Morano I, Calvini T, Studer R, Holtz J (1994) Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy. Biochem Biophys Res Commun 205:905-910
15. Griffith TM, Edwards DH, Davies RL, Harrison TJ, Evans KT (1987) EDRF coordinates the behaviour of vascular resistance vessels. Nature 329:442-445
16. Groenendijk R, Trimbos JMBJ, Wallenburg HCS (1984) Haemodynamic measurements in preeclampsia preliminary observations. Am J Obstet Gynecol 150:232-236
17. Hayward C, Livingstone J, Holloway S, Liston WA, Brock DJH (1992) An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. Am J Hum Genet 50:749-757
18. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowithz A, Bevan JA, Fishman MC (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 77: 239-242
19. Humphries JO (1960) Occurrence of hypertensive toxemia of pregnancy in mother-daughter pairs. Bull John Hopkins Hosp 107:271-277
20. Kaku M, Nagata H (1955) Hypertensive lineage and toxemia of pregnancy. Am J Obstet Gynecol 78:399-404
21. Kovacs GA, Makary A, Peto J, Steinmetz G (1994) Deficiency of c-GMP in placental circulation in pregnancy induced hypertensive disorders: possibility of decreased endothelium relaxing factor activity. Hypertens Pregnancy 13:163-169
22. Kuokkanen S, Sundvall M, Terwilliger JD, Tienari PJ, Wikstrom J, Holmdahl-R, Pettersson U, et al (1996) A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat Genet 13:477-480
23. Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies of multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81:3443-3446
24. Liston WA, Kilpatrick DC (1991) Is genetic susceptibility to preeclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? Br J Obstet Gynaecol 98:1079-1086
25. McCarthy AL, Woolfson RG, Raju SK, Poston L (1993) Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am J Obstet Gynecol 168:1323-1330
26. Molnar M, Suto T, Toth T, Hertelendy F (1994) Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia and intrauterine growth retardation. Am J Obstet Gynecol 170: 1458-1466
27. Nadaud S, Bonnardeaux A, Lathrop GM, Soubrier F (1994) Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene. Biochem Biophys Res Commun 198:1027-1033
28. Nathan L, Cueva SJ, Chauduri G (1995) The role of nitric oxide in the altered reactivity of pregnancy in rat. Br J Pharmacol 114:955-960
29. Ott J (1991) Analysis of human genetic linkage. John Hopkins University Press, London
30. Ramsay B, DeBelder A, Campbell S, Moncada S, Martin JF (1994) A nitric oxide donor improves uterine artery diastolic blood flow in normal pregnancy and in women at high risk of preeclampsia. J Clin Invest 24:76-78
31. Redman CWG (1989) Hypertension in pregnancy. In: Turnbull A, Chamberlain G (eds) Obstetrics. Churchill Livingstone, Edinburgh, pp 515-541
32. Redman CWG, Allington MJ, Bolton FG, Stirrat GM (1977) Plasma beta thromboglobulin in preeclampsia Lancet 2:248
33. Roberts JM, Redman CWG (1993) Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 341:1447-1451
34. Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger JD, et al (1996) Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 14:199-202
35. Sibai BM, McCubbin JH, Anderson GD, Lipshitz J, Dilts PV Jr (1981) Eclampsia. I. Observations from 67 recent cases. Obstet Gynecol 58:609-613
36. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
37. Takimoto E, Ishida J, Sugiyama F, Horiguchi H, Murakami, Fukamizu A (1996) Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science 274:995-998
38. Terwilliger JD (1995) A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56: 777-787
39. Ward K, Hata A, Jeunemaitre X, Helin C, Nelson L, Namikawa C, Farrington PF, et al (1993) A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet 4:59-60
40. Weeks DE, Lange K (1992) A multilocus extension of the affected-pedigree-member method of linkage analysis. Am J Hum Genet 50:859-868
41. Weissenbach J, Gyapay G, Dib C, Vignal A, Morsissette J, Milasseau P, Vaysseix G, et al (1992) A second generation linkage map of the human genome. Nature 359:794-801
42. Wilton AN, Cooper DW, Brennecke SP, Bishop SM, Marshall P (1990) Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DRβ. Lancet 336:653-657
43. Wilton AN, Kaye JA, Guo G, Brennecke SP, Cooper DW (1995) Is angiotensinogen a good candidate gene in pre-eclampsia. Hypertens Pregnancy 14:251-260
44. Yallampalli C, Garfield RE (1993) Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 169:1316-1320