Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-κB signaling

Biochemical Pharmacology

Volumn 65, Issue 1, 2003, Pages 91-99

  Littlejohn, Alison F ^a   Tucker, Steven J ^a   Mohamed, Ahmed A A ^a   McKay, Stephen ^a   Helms, Matt J ^a   Vandenabeele, Peter ^b   MacEwan, David J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Apoptosis; Cytokine receptors; Human; Inflammation; Signal transduction; Transcription factor

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLGLUTAMYLISOLEUCYLASPARTYL FLUOROMETHYLKETONE; CASPASE 3; CASPASE INHIBITOR; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANTIGENS, CD; CASPASES; ENZYME ACTIVATION; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037212323     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01443-0     Document Type: Article

References (46)

1. Kriegler M., Perez C., Defay K., Albert I., Lu S.D. A novel form of TNF/cachectin is a cell-surface cytotoxic transmembrane protein - ramifications for the complex physiology of TNF. Cell. 53:1988;45-53.
2. Vandenabeele P., Declerq W., Beyaert R., Fiers W. Two tumour necrosis factor receptors: structure and function. Trends Cell. Biol. 5:1995;392-399.
3. Chan F.K.M., Chun H.J., Zheng L.X., Siegel R.M., Bui K.L., Lenardo M.J. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 288:2000;2351-2354.
4. Tartaglia L.A., Ayres T.M., Wong G.H.W., Goeddel D.V. A novel domain within the 55 kDa TNF receptor signals cell-death. Cell. 74:1993;845-853.
5. MacEwan D.J. TNF ligands and receptors - a matter of life and death. Br. J. Pharmacol. 135:2002;855-875.
6. Heller R.A., Song K., Fan N., Chang D.J. The p70 tumor-necrosis-factor receptor mediates cytotoxicity. Cell. 70:1992;47-56.
7. Declercq W., Denecker G., Fiers W., Vandenabeele P. Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. J. Immunol. 161:1998;390-399.
8. Tartaglia L.A., Pennica D., Goeddel D.V. Ligand passing - the 75-kDa tumor-necrosis-factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J. Biol. Chem. 268:1993;18542-18548.
9. Chen Z.J., Hagler J., Palombella V.J., Melandri F., Scherer D., Ballard D., Maniatis T. Signal-induced site-specific phosphorylation targets I-κ-B-α to the ubiquitin-proteasome pathway. Genes Dev. 9:1995;1586-1597.
10. Chen Z.J., Parent L., Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell. 84:1996;853-862.
11. Karin M., Delhase M. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin. Immunol. 12:2000;85-98.
12. Hsu H.L., Shu H.B., Pan M.G., Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 84:1996;299-308.
13. Stanger B.Z., Leder P., Lee T.H., Kim E., Seed B. RIP - a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell-death. Cell. 81:1995;513-523.
14. Liu Z.G., Hsu H.L., Goeddel D.V., Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κ B activation prevents cell death. Cell. 87:1996;565-576.
15. Devin A., Cook A., Lin Y., Rodriguez Y., Kelliher M., Liu Z.G. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity. 12:2000;419-429.
16. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M., Avruch J., Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
17. Tournier C., Dong C., Turner T.K., Jones S.N., Flavell R.A., Davis R.J. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 15:2001;1419-1426.
18. Weiss T., Grell M., Siemienski K., Muhlenbeck F., Durkop H., Pfizenmaier K., Scheurich P., Wajant H. TNFR80-dependent enhancement of TNFR60-induced cell death is mediated by TNFR-associated factor 2 and is specific for TNFR60. J. Immunol. 161:1998;3136-3142.
19. Haridas V., Darnay B.G., Natarajan K., Heller R.A., Aggarwal B.B. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-κB activation, and c-Jun kinase activation. J. Immunol. 160:1998;3152-3162.
20. Jupp O.J., McFarlane S.M., Anderson H.M., Littlejohn A.F., Mohamed A.A.A., MacKay R.H., Vandenabeele P., MacEwan D.J. Type II tumour necrosis factor-a receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways. Biochem. J. 359:2001;525-535.
21. Xia Z.G., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
22. Bozyczko-Coyne D., O'kane T.M., Wu Z.L., Dobrzanski P., Murthy S., Vaught J.L., Scott R.W. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with a beta-induced cortical neuron apoptosis. J. Neurochem. 77:2001;849-863.
23. Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitzfriedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 380:1996;75-79.
24. Doman R.K., Perez M., Donato N.J. JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis. J. Interferon Cytokine Res. 19:1999;261-269.
25. Helms M.L., Mohamed A.A.A., MacEwan D.J. Modulated kinase activities, in cells undergoing tumour necrosis, factor-induced apoptotic cell death. FEBS Lett. 505:2001;68-74.
26. Locksley R.M., Killeen N., Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 104:2001;487-501.
27. Denecker G., Vercammen D., Declercq W., Vandenabeele P. Apoptotic and necrotic cell death induced by death domain receptors. Cell Mol. Life Sci. 58:2001;356-370.
28. Kinloch R.A., Treherne M., furness M. Hajimohamadreza, I, The pharmacology of apoptosis. Trends Pharmacol. Sci. 20:1999;35-42.
29. Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13:1999;2514-2526.
30. Pollock V.P., Lofthouse E.J., Jupp O.J., Gauld S.B., Anderson H.M., MacEwan D.J. Selective down-regulation of the Gqα/G11α G-protein family in tumour necrosis factor-a induced cell death. Mol. Cell. Biochem. 206:2000;67-74.
31. Rodriguez M.S., Wright J., Thompson J., Thomas D., Baleux F., Virelizier J.L., Hay R.T., Arenzanaseisdedos F. Identification of lysine residues required for signal-induced ubiquitination and degradation of IκB-α in vivo. Oncogene. 12:1996;2425-2435.
32. McFarlane S.M., Pashmi G., Connell M.C., Littlejohn A.F., Tucker S.J., Vandenabeele P., MacEwan D.J. Differential activation of nuclear factor-κB by tumour necrosis factor receptor subtypes. TNFR1 predominates whereas TNFR2 activates transcription poorly. FEBS Lett. 515:2002;119-126.
33. Baxter G.T., Kuo R.C., Jupp O.J., Vandenabeele P., MacEwan D.J. Tumor necrosis factor-a mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. J. Biol. Chem. 274:1999;9539-9547.
34. Grell M., Douni E., Wajant H., Lohden M., Clauss M., Maxeiner B., Georgopoulos S., Lesslauer W., Kollias G., Pfizenmaier K., Scheurich P. The transmembrane form of tumor-necrosis-factor is the prime activating ligand of the 80 kDa tumor-necrosis-factor receptor. Cell. 83:1995;793-802.
35. Mohamed AAA, Jupp OJ, Anderson HM, Littlejohn AF, Vandenabeele P, MacEwan DJ. Tumour necrosis factor-induced activation of c-Jun N-terminal kinase is sensitive to caspase-dependent modulation while activation of mitogen-activated protein kinase (MAPK) or p38MAPK is not. Biochem J 2002;366:144-55.
36. Foo S.Y., Nolan G.P. NF-κB to the rescue - rels, apoptosis and cellular transformation. Trends Genet. 15:1999;229-235.
37. McFarlane M., Cohen G.M., Dickens M. JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem. J. 348:2000;93-101.
38. Muhlenbeck F., Haas E., Schwenzer R., Schubert G., Grell M., Smith C., Scheurich P., Wajant H. TRAIL/APO2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways. J. Biol. Chem. 273:1998;33091-33098.
39. Chaudhary P.M., Eby M.T., Jasmin A., Kumar A., Liu L., Hood L. Activation of the NF-κB pathway by caspase 8 and its homologs. Oncogene. 19:2000;4451-4460.
40. Chaudhary P.M., Jasmin A., Eby M.T., Hood L. Modulation of the NF-κB pathway by virally encoded death effector domains-containing proteins. Oncogene. 18:1999;5738-5746.
41. Chaudhary P.M., Eby M.T., Jasmin A., Hood L. Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs. J. Biol. Chem. 274:1999;19211-19219.
42. Hu W.H., Johnson H., Shu H.B. Activation of NF-κB by FADD, casper, and caspase-8. J. Biol. Chem. 275:2000;10838-10844.
43. Wajant H., Henkler F., Scheurich P. The TNF-receptor-associated factor family - scaffold molecules for cytokine receptors, kinases and their regulators. Cell. Signal. 13:2001;389-400.
44. Harper N., Farrow S.N., Kaptein A., Cohen G.M., McFarlane M. Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-κB activation by inhibition of apical caspases. J. Biol. Chem. 276:2001;34743-34752.
45. Reuther J.Y., Baldwin A.S. Apoptosis promotes a caspase-induced amino-terminal truncation of IκBα that functions as a stable inhibitor of NF-κB. J. Biol. Chem. 274:1999;20664-20670.
46. Barkett M., Xue D., Horvitz H.R., Gilmore T.D. Phosphorylation of IκB-α inhibits its cleavage by caspase CPP32 in vitro. J. Biol. Chem. 272:1997;29419-29422.