Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones

Neurochemistry International

Volumn 42, Issue 1, 2003, Pages 35-43

  Nagy, József ^a   Kolok, Sándor ^a   Dezso, Péter ^a   Boros, András ^a   Szombathelyi, Zsolt ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

Alcohol abuse; Expression of NMDA receptor; Neurones

Indexed keywords

5,7 DICHLOROKYNURENIC ACID; ALCOHOL; CI 1041; DIZOCILPINE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; TRAXOPRODIL; UNCLASSIFIED DRUG;

ALCOHOL WITHDRAWAL; ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CELL CULTURE; CELL LOSS; CONTROLLED STUDY; EMBRYO; FLOW CYTOMETRY; GENE CASSETTE; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA, SERUM-FREE; DIZOCILPINE MALEATE; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; KYNURENIC ACID; N-METHYLASPARTATE; NERVE TISSUE PROTEINS; NEURONS; PIPERIDINES; PROTEIN SUBUNITS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA SPLICING;

EID: 0037210365     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00062-1     Document Type: Article

References (48)

1. Ahern K.B., Lustig H.S., Greenberg D.A. Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol. Neurosci. Lett. 165:1994;211-214.
2. Ballenger J.C., Post R.M. Kindling as a model for alcohol withdrawal syndromes. Br. J. Psychiatry. 133:1978;1-13.
3. Bigge C.F. Ionotropic glutamate receptors. Curr. Opin. Chem. Biol. 3:1999;441-447.
4. Blevins T., Mirshahi T., Woodward J.J. Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci. Lett. 200:1995;214-218.
5. Chandler L.J., Newsom H., Sumners C., Crews F.T. Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J. Neurochem. 60:1993;1578-1581.
6. Chandler L.J., Norwood D., Sutton G. Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures. Alcohol Clin. Exp. Res. 23(2):1999;363-369.
7. Chen X., Michaelis M.L., Michaelis E.K. Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA/glutamate receptor proteins in brain synaptic membranes. J. Neurochem. 69(4):1997;1559-1569.
8. Collins M.A., Zou J., Neafsey E.J. Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism. FASEB J. 12:1998;221-230.
9. Cull-Candy S., Brickley S., Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11:2001;327-335.
10. Crews F.T., Morrow A.L., Criswell H., Breese G.R. Effects of ethanol on ion channels. Int. Rev. Neurobiol. 39:1996;283-367.
11. Das S., Sasaki Y.F., Rothe T., Premkumar L.S., Takasu M., Crandall J.E., Dikkes P., Conner D.A., Rayudu P.V., Cheung W., Chen H.S., Lipton S.A., Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 393:1998;377-381.
12. Devaud L.L., Morrow A.L., Nguyen U.T.Q. Ovariectomy has minimal e.ects on neuroadaptations associated with ethanol dependence in female rats. Neurochem. Int. 37:2000;433-442.
13. Follesa P., Ticku M.K. NMDA receptor upregulation: molecular studies in cultured mouse cortical neurons after chronic antagonist exposure. J. Neurosci. 16:1996a;2172-2178.
14. Follesa P., Ticku M.K. Chronic ethanol mediated upregulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J. Biol. Chem. 271:1996;13297-13299.
15. Freed, W.J., Michaelis, E.K., 1978. Glutamic acid and ethanol dependence. Pharmacol. Biochem. Behav. 8 (5), 509-514.
16. Hardy P.A., Chen W., Wilce P.A. Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex. Brain Res. 819:1999;33-39.
17. Hoffman P.L., Tabakoff B. The role of the NMDA receptor in ethanol withdrawal. EXS. 71:1994;61-70.
18. Hu X.L., Follesa P., Ticku M.K. Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Mol. Brain Res. 36:1996;211-218.
19. Hu X.L., Ticku M.K. Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure. Brain Res. 767:1997;228-234.
20. Iorio K.R., Reinlib L., Tabakoff B., Hoffman P.L. Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol. Pharmacol. 41:1992;1142-1148.
21. Kalluri H.S.G., Mehta A.K., Ticku M.K. Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Mol. Brain Res. 58:1998;221-224.
22. Koltchine, V., Anantharam, V., Wilson, A., Bayley, H., Treistman, S.N., 1993. Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci. Lett. 152 (1-2), 13-16.
23. Koob G.F., Bloom F.E. Cellular and molecular mechanisms of drug dependence. Science. 242:1988;715-723.
24. Kumari M. Differential effects of chronic ethanol treatment on N-methyl-D-aspartate R1 splice variants in fetal cortical neurons. J. Biol. Chem. 276(32):2001;29764-29771.
25. Lovinger D.M. Excitotoxicity and alcohol-related brain damage. Alcohol Clin. Exp. Res. 17:1993;19-27.
26. Masood K., Wu C., Brauneis U., Weight F.F. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol. Pharmacol. 45:1994;324-329.
27. 2+-insensitive mutants. Neuropharmacology. 34:1995;347-355.
28. Mirshahi T., Anders D.L., Ronald K.M., Woodward J.J. Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit. J. Neurochem. 71(3):1998;1095-1107.
29. Monyer H., Sprengler R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., Seeburg P.H. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 256:1992;1217-1221.
30. Mori, H., Mishina, M., 1995. Structure and function of the NMDA receptor channel. Neuropharmacology 34, 1219-1237.
31. A and NMDA receptor subunit mRNA expression in ethanol dependent rats. Alcohol Alcohol. 2:1994;89-95.
32. Nagy J., Müller F., László L. Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones. Drug Alcohol Depend. 61:2001;155-162.
33. Nagy J., László L. Increased sensitivity to NMDA is involved in alcohol-withdrawal induced cytotoxicity observed in primary cultures of cortical neurones chronically pre-treated with ethanol. Neurochem. Int. 40:2002;585-591.
34. Narita M., Soma M., Mizoguchi H., Tseng L.F., Suzuki T. Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence. Eur. J. Pharmacol. 401(2):2000;191-195.
35. Nestler, E.J., Hope, B.T., Widnell, K.L., 1993. Drug addiction: A model for the molecular basis of neural plasticity. Neuron. 11 (6), 995-1006.
36. Poelchen W., Kittner H., Sieler D., Regenthal R., Preiss R., Illes P. In vitro tolerance to inhibition by ethanol of N-methyl-D-aspartate-induced depolarization in locus coeruleus neurons of behaviorally ethanol-tolerant rats. Neurochem. Int. 39:2001;51-58.
37. Popp R.L., Lickteig R., Browning M.D., Lovinger D.M. Ethanol sensitivity and subunit composition of NMDA receptors in cultured striatal neurons. Neuropharmacology. 37:1998;45-56.
38. Prendergast M.A., Harris B.R., Blanchard J.A. II, Mayer S., Gibson D.A., Littleton J.M. In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat. Alcohol Clin. Exp. Res. 24(12):2000;1855-1861.
39. al-Qatari M., Khan S., Harris B., Littleton J. Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin. Exp. Res. 25(9):2001;1276-1283.
40. Rameau A.G., Akaneya Y., Chiu L.Y., Ziff E.B. Role of NMDA receptor functional domains in excitatory cell death. Neuropharmacology. 39:2000;2255-2266.
41. Rudolph J.G., Lemasters J.J., Crews F.T. Effects of chronic ethanol exposure on oxidation and NMDA-stimulated neuronal death in primary cortical neuronal cultures. Alcohol Clin. Exp. Res. 22:1998;2080-2085.
42. Rumbaugh, G., Prybylowski, K., Wang, J.F., Vicini, S., 2000. Exon 5 and spermine regulate deactivation of NMDA receptor subtypes. J. Neurophysiol. 83 (3), 1300-1306.
43. Smothers C.T., Mrotek J.J., Lovinger D.M. Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons. J. Pharmacol. Exp. Ther. 283:1997;1214-1222.
44. Smothers C.T., Clayton R., Blevins T., Woodward J.J. Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors. Neurochem. Int. 38:2001;333-340.
45. Snell L.D., Bhave S.V., Tabakoff B., Hoffman P.L. Chronic ethanol exposure delays the developmental switch of the NMDA receptor 2A and 2B subunits in cultured cerebellar granule neurones. J. Neurochem. 78:2001;396-405.
46. Trevisan L., Fitzgerald L.W., Brose N., Gasic G.P., Heinemann S.F., Duman R.S., Nestler E.J. Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J. Neurochem. 62(4):1994;1635-1638.
47. Tsien R.Y., Pozzan T., Rink T.J. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J. Cell. Biol. 94:1982;325-334.
48. Winkler A., Mahal B., Kiianmaa K., Zieglgansberger W., Spanagel R. Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats. Brain Res. Mol. Brain Res. 72(2):1999;166-175.