Chronic ethanol exposure leads to a selective enhancement of N-methyl- D-aspartate receptor function in cultured hippocampal neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1214-1222

  Smothers, C Thetford ^a   Mrotek, James J ^a   Lovinger, David M ^b  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; FETUS; HIPPOCAMPUS; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HIPPOCAMPUS; N-METHYLASPARTATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0031470568     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. AHERN, K. B., LUSTIG, H. S. AND GREENBERG, D. A.: Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol. Neurosci. Lett. 165: 211-214, 1994.
2. BANKER, G. A. AND COWAN, W. M.: Rat hippocampal neurons in dispersed cell culture. Brain Res. 126: 397-425, 1977.
3. BENNETT, M. R. AND HUXLIN, K. R.: Neuronal cell death in the mammalian nervous system: the calmortin hypothesis. Gen. Pharmacol. 27: 407-419, 1996.
4. BHAVE, S. V., SNELL, L. D., TABAKOFF, B. AND HOFFMAN, P. L.: Mechanism of ethanol inhibition of NMDA receptor function in primary cultures of cerebral cortical cells. Alcohol. Clin. Exp. Res. 20: 934-941, 1996.
5. BLEVINS, T., MIRSHAHI, T. AND WOODWARD, J. J.: Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci. Lett. 200: 214-518, 1995.
6. CHANDLER, L. J., NEWSOM, H., SUMNERS, C. AND CREWS, F.: Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J. Neurochem. 60: 1578-1581, 1993.
7. CHURN, S. B., LIMBRICK, D., SOMBATI, S. AND DELORENZO, R. J.: Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. J. Neurosci. 15: 3200-3214, 1995.
8. COLLINS, M. A., CORSO, T. D. AND NEAFSEV, E. J.: Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "Binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol. Clin. Exp. Res. 20: 284-292, 1996.
9. COYLE, J. T. AND PUTTFARCKEN, P.: Oxidative stress, glutamate, and neurode-generative disorders. Science 262: 689-695, 1993.
10. DAVIDSON, M. D., WILCE, P. AND SHANLEY, B. C.: Increased sensitivity of the hippocampus in ethanol-dependent rats to toxic effect of N-methyl-D-aspartic acid in vivo. Brain Res. 606: 5-9, 1993.
11. DILDY-MAYFIELD, J. E. AND HARRIS, R. A.: Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: role of calcium and protein kinase C. J. Neurosci. 15: 3162-3171, 1995.
12. FOLLESA, P. AND TICKU, M. K.: Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Mol. Brain Res. 29: 99-106, 1995.
13. FOLLESA, P. AND TICKU, M. K.: Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J. Biol. Chem. 271: 13297-13299, 1996.
14. FREUND, G. AND ANDERSON, K. J.: Glutamate receptors in the frontal cortex of alcoholics. Alcohol. Clin. Exp. Res. 20: 1165-1172, 1996.
15. GRANT, E. R., BACSKAI, B. J., PLEASURE, D. E., PRITCHETT, D. B., GALLAGHER, M. J., KENDRICK, S. J., KRICKA, L. J. AND LYNCH, D. R.: N-methyl-D-aspartate receptors expressed in a nonneuronal cell line mediate subunit-specific increases in free intracellular calcium. J. Biol. Chem. 272: 647-656, 1997.
16. GRANT, K. A., VALVERIUS, P., HUDSPITH, M. AND TABAKOFF, B.: Ethanol withdrawal seizures and the NMDA receptor complex. Eur. J. Pharmacol. 176: 289-296, 1990.
17. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
18. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci. 13: 1993-2000, 1993.
19. 1. Alcohol. Clin. Exp. Res. 19: 721-726, 1995.
20. HU, X.-J. AND TICKU, M. K.: Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Mol. Brain Res. 30: 347-356, 1995.
21. 2+ channels of hippocampal neurons of long-sleep but not short-sleep mice. Brain Res. 615: 328-330, 1993.
22. IORIO, K. R., REINLIB, L., TABAKOFF, B. AND HOFFMAN, P. L.: Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D aspartate receptor function. Mol. Pharmacol. 41: 1142-1148, 1992.
23. IORIO, K. R., TABAKOFF, B. AND HOFFMAN, P. L.: Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol. Eur. J. Pharmacol. 248: 209-212, 1993.
24. KOH, J. AND CHOI, D. W.: Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J. Neurosci. 8: 2153-2163, 1988.
25. KOLTCHINE, V. V., ANANTHARAM, V., BAYLEY, H. AND TREISTMAN, S. N.: Alternative splicing of the NMDAR1 subunit affects modulation by calcium. Mol. Brain Res. 39: 99-108, 1996.
26. KRILL, J. J., HALLIDAY, G. M., SVOBODA, M. AND CARTWRIGHT, R.: Cortical neuronal loss in alcoholics: Fact or fiction? Alcohol. Clin. Exp. Res. 19: 95A, 1995.
27. 2+ block in NMDA receptor channels. J. Neurosci. 16: 3549-3558, 1996.
28. LESLIE, S. W., BROWN, L. M., DILDY, J. E. AND SIMS, J. S.: Ethanol and neuronal calcium channels. Alcohol 7: 233-236, 1990.
29. LOVINGER, D. M.: Excitotoxicity and alcohol-related brain damage. Alcohol. Clin. Exp. Res. 17: 19-27, 1993.
30. LOVINGER, D. M., WHITE, G. AND WEIGHT, F. F.: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721-1724 1989.
31. LUNDQVIST, C., ALLING, C., KNOTH, R. AND VOLK, B.: Intermittent ethanol exposure of adult rats: hippocampal cell loss after one month of treatment. Alcohol Alcohol. 30: 737-748, 1995.
32. MARTIN, D., TAYYEB, M. I. AND SWARTZWELDER, H. S.: Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. Alcohol. Clin. Exp. Res. 19: 1312-1316, 1995.
33. MATTSON, M. P., RYCHLIK, B., CHU, C. AND CHRISTAKOS, S.: Evidence for calcium-reducing and excito-protective roles for the calcium-binding protein calbindin-D28k in cultured hippocampal neurons. Neuron 6: 41-51, 1991.
34. MATTSON, M. P., DOU, P. AND KATER, S. B.: Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons. J. Neurosci. 8: 2087-2100, 1988.
35. MAYER, M. AND WESTBROOK, G.: Permeation and block of NMDA receptor channels by divalent cations in mouse cultured central neurones. J. Physiol. (Lond.) 394: 501-527, 1987.
36. MICHAELIS, E. K., FREED, W. J., GALTON, N., FOYE, J., MICHAELIS, M. L., PHILLIPS, I. AND KLEINMAN, J. E.: Glutamate receptor changes in brain synaptic mem-branes from human alcoholics. Neurochem. Res. 15: 1055-1063, 1990.
37. MONYER, H., BURNASHEV, N., LAURIE, D. J., SAKMANN, B. AND SEEBURG, P. H.: Developmental and regional expression of the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540, 1994.
38. RANDOLL, L. A., WILSON, W. R., WEAVER, M. S., SPUHLER-PHILLIPS, K. AND LESLIE, S. W.: N-methyl-D-aspartate-stimulated increases in intracellular calcium exhibit brain regional differences in sensitivity to inhibition by ethanol. Alcohol. Clin. Exp. Res. 20: 197-200, 1996.
39. RIPLEY, T. L., WHITTINGTON, M. A., BUTTERWORTH, A. R. AND LITTLE, H. J.: Ethanol withdrawal hyperexcitability in vivo and in isolated mouse hippocampal slices. Alcohol Alcohol. 31: 347-357, 1996.
40. SNELL, L. D., NUNLEY, K. R., LICKTEIG, R. L., BROWNING, M. D., TABAKOFF, B. AND HOFFMAN, P. L.: Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol. Brain Res. 40: 71-78, 1996.
41. SNELL, L. D., TABAKOFF, B. AND HOFFMAN, P. L.: Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: Alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res. 602: 91-98, 1993.
42. TREVISAN, L., FITZGERALD, L. W., BROSE, N., GASIC, G. P., HEINEMANN, S. F., DUMAN, R. S. AND NESTLER, E. J.: Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J. Neurochem. 62: 1635-1638, 1994.
43. TYMIANSKI, M., CHARLTON, M. P., CARLEN, P. L. AND TATOR, C. H.: Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J. Neurosci. 13: 2085-2104, 1993.
44. WALKER, D. W., KING, M. A. AND HUNTER, B. E.: Alterations in the structure of the hippocampus after long-term ethanol consumption. In Alcohol-Induced Brain Damage: NIAAA Research Monograph no. 22, ed. by W. A. Hunt and S. J. Nixon, pp. 231-248, National Institutes of Health Publications, Washington, DC, 1993.
45. WHETSELL, W. O.: Current concepts of excitotoxicity. J. Neuropathol. Exp. Neurol. 55: 1-13, 1996.
46. WHITTINGTON, M. A., LAMBERT, J. D. AND LITTLE, H. J.: Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol Alcohol. 30: 105-114, 1995.
47. WHITTINGTON, M. A. AND LITTLE, H. J.: Changes in voltage-operated calcium channels modify ethanol withdrawal hyperexcitability in mouse hippocampal slices. Exp. Physiol. 78: 347-370, 1993.
48. WILLIAMS, K., DICHTER, M. A. AND MOLINOFF, P. B.: Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists. Mol. Pharmacol. 42: 147-151, 1992.